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View article: Nanodecoys Unleash Immune Potential To Reprogram Robust Anti-Tumor Defense
Nanodecoys Unleash Immune Potential To Reprogram Robust Anti-Tumor Defense Open
Aim or purpose: The deficiency of robust cytotoxic T lymphocyte (CTL) response and sustained anti-tumor microenvironment represents persistent dilemmas during tumor immunotherapy. Hence, rebooting the immune system to overcome existing int…
View article: Exosomal FASN Impairs Diabetic Wound Angiogenesis Via Mitochondrial Dysfunction
Exosomal FASN Impairs Diabetic Wound Angiogenesis Via Mitochondrial Dysfunction Open
Aim or purpose: To delineate how Fasn-enriched circulating exosomes in diabetes disrupt endothelial lipid homeostasis and angiogenesis via mitochondrial regulation in the wound healing process. Materials and methods: Serum exosomes from ty…
View article: Mscs Apoptotic Vesicles Attenuated Endothelial Cell Ferroptosis For Angiogenesis
Mscs Apoptotic Vesicles Attenuated Endothelial Cell Ferroptosis For Angiogenesis Open
Aim or purpose: Investigating adipose-derived stem cell apoptotic vesicles (ASCs-apoVs) as angiogenic mediators through ferroptosis inhibition for enhanced diabetic wound repair. Materials and methods: C57BL/6J mice were fed a high-fat die…
View article: Inhibition of Ferroptosis by Adipose Stem Cell-Derived Apoptotic Vesicles Enhances Angiogenesis and Accelerates Diabetic Wound Healing
Inhibition of Ferroptosis by Adipose Stem Cell-Derived Apoptotic Vesicles Enhances Angiogenesis and Accelerates Diabetic Wound Healing Open
Ferroptosis of endothelial cells contributes to impaired vascularization in diabetic wounds. ApoVs represent a promising cell-free therapeutic approach to mitigate ferroptosis, restore endothelial function and promote angiogenesis, offerin…
View article: Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation
Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation Open
Organisms constantly encounter unpredictable environmental perturbations, necessitating adaptation to maintain homeostasis. However, the fundamental principles by which organisms identify specific cues and transition to an adaptive state r…
View article: Lipid metabolism of apoptotic vesicles accelerates cutaneous wound healing by modulating macrophage function
Lipid metabolism of apoptotic vesicles accelerates cutaneous wound healing by modulating macrophage function Open
The application of apoptotic extracellular vesicles (ApoEVs) derived from stem cell in skin wound healing has garnered significant attention. In recent decades, scholars have shown that extracellular vesicles (EVs) established intercellula…
View article: T Cell‐Derived Apoptotic Extracellular Vesicles Hydrolyze cGAMP to Alleviate Radiation Enteritis via Surface Enzyme ENPP1
T Cell‐Derived Apoptotic Extracellular Vesicles Hydrolyze cGAMP to Alleviate Radiation Enteritis via Surface Enzyme ENPP1 Open
Radiation enteritis is the most common complication of pelvic radiotherapy, but there is no effective prevention or treatment drug. Apoptotic T cells and their products play an important role in regulating inflammation and maintaining phys…
View article: Engineered Extracellular Vesicles Driven by Erythrocytes Ameliorate Bacterial Sepsis by Iron Recycling, Toxin Clearing and Inflammation Regulation
Engineered Extracellular Vesicles Driven by Erythrocytes Ameliorate Bacterial Sepsis by Iron Recycling, Toxin Clearing and Inflammation Regulation Open
Sepsis poses a significant challenge in clinical management. Effective strategies targeting iron restriction, toxin neutralization, and inflammation regulation are crucial in combating sepsis. However, a comprehensive approach simultaneous…
View article: Bone-Targeting Peptide and RNF146 Modified Apoptotic Extracellular Vesicles Alleviate Osteoporosis
Bone-Targeting Peptide and RNF146 Modified Apoptotic Extracellular Vesicles Alleviate Osteoporosis Open
To promote the bone-targeting ability of natural ApoEVs, we successfully synthesized engineered ApoEVs, (DSS)6-ApoEVsRNF146 and found that they could significantly promote osteogenesis and alleviate osteoporosis compared with natural ApoEV…
View article: Proteomic analysis identifies Stomatin as a biological marker for psychological stress
Proteomic analysis identifies Stomatin as a biological marker for psychological stress Open
Psychological stress emerges to be a common health burden in the current society for its highly related risk of mental and physical disease outcomes. However, how the quickly-adaptive stress response process connects to the long-observed o…
View article: Hybrid Biomaterial Initiates Refractory Wound Healing via Inducing Transiently Heightened Inflammatory Responses
Hybrid Biomaterial Initiates Refractory Wound Healing via Inducing Transiently Heightened Inflammatory Responses Open
Inflammation plays a crucial role in triggering regeneration, while inadequate or chronic inflammation hinders the regenerative process, resulting in refractory wounds. Inspired by the ideal regeneration mode in lower vertebrates and the h…
View article: Exosomes-Based Humoral Regulation of Iron Metabolism is Required for Host Antibacterial Response
Exosomes-Based Humoral Regulation of Iron Metabolism is Required for Host Antibacterial Response Open
Immediate iron restriction by the host is a critical process to protect against bacterial infections. Although the cell-dependent iron sequestration mechanism in liver or spleen has been identified, it is still unclear that whether the hos…
View article: Synergistic antibiosis with spatiotemporal controllability based on multiple-responsive hydrogel for infectious cutaneous wound healing
Synergistic antibiosis with spatiotemporal controllability based on multiple-responsive hydrogel for infectious cutaneous wound healing Open
Bacterial infection is one of serious problems hindering tissue regeneration, but strategies able to perform proper antibiosis with spatiotemporal controllability to manipulate the local inflammation and immunity for effective healing of i…
View article: Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation
Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation Open
Chimeric apoptotic bodies promote M2 polarization of macrophages to modulate inflammation.
View article: Additional file 4 of Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages
Additional file 4 of Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages Open
Additional file 4. Additional Tables 1–7 Data tables summarizing the mean and standard deviation of the data obtained.
View article: Application of surgical navigation in styloidectomy for treating Eagle’s syndrome
Application of surgical navigation in styloidectomy for treating Eagle’s syndrome Open
The higher accuracy of surgery, lesser amount of bleeding, decreased duration of surgery and hospitalization, absence of complications, and improved subjective symptoms indicated that SN is an effective and minimally invasive surgical proc…