Gengshan Wu
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View article: Delivery of <i>Yersinia pestis</i> antigens via <i>Escherichia coli</i> outer membrane vesicles offered improved protection against plague
Delivery of <i>Yersinia pestis</i> antigens via <i>Escherichia coli</i> outer membrane vesicles offered improved protection against plague Open
Outer membrane vesicles (OMVs) from Gram-negative bacteria can be used as a vaccine platform to deliver heterologous antigens. Here, the major protective antigens of Yersinia pestis, F1 and LcrV, were fused either with the leader sequence …
View article: A protein O-GlcNAc glycosyltransferase regulates the antioxidative response in Yersinia pestis
A protein O-GlcNAc glycosyltransferase regulates the antioxidative response in Yersinia pestis Open
View article: Unveiling the dance of evolution: Pla-mediated cleavage of Ymt modulates the virulence dynamics of <i>Yersinia pestis</i>
Unveiling the dance of evolution: Pla-mediated cleavage of Ymt modulates the virulence dynamics of <i>Yersinia pestis</i> Open
Yersinia pestis has recently evolved into a highly lethal flea-borne pathogen through the pseudogenization of extensive genes and the acquisition of exogenous plasmids. Particularly noteworthy are the newly acquired pPCP1 and pMT1 plasmids…
View article: A novel sORF gene mutant strain of Yersinia pestis vaccine EV76 offers enhanced safety and improved protection against plague
A novel sORF gene mutant strain of Yersinia pestis vaccine EV76 offers enhanced safety and improved protection against plague Open
We recently identified two virulence-associated small open reading frames (sORF) of Yersinia pestis , named yp1 and yp2 , and null mutants of each individual genes were highly attenuated in virulence. Plague vaccine strain EV76 is known fo…
View article: Subversion of GBP-mediated host defense by E3 ligases acquired during Yersinia pestis evolution
Subversion of GBP-mediated host defense by E3 ligases acquired during Yersinia pestis evolution Open
View article: Highly Specific and Sensitive Detection of Yersinia pestis by Portable Cas12a-UPTLFA Platform
Highly Specific and Sensitive Detection of Yersinia pestis by Portable Cas12a-UPTLFA Platform Open
The recent discovery of collateral cleavage activity of class-II clustered regularly interspaced short palindromic repeats–CRISPR-associated protein (CRISPR-Cas) makes CRISPR-based diagnosis a potential high-accuracy nucleic acid detection…