Genki Ishihara
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View article: Superoxide- and semiquinone-linked activation of molecular hydrogen in metal-catalyst-free solution
Superoxide- and semiquinone-linked activation of molecular hydrogen in metal-catalyst-free solution Open
The therapeutic effects of molecular hydrogen (H 2 ), particularly in ischemia-reperfusion (I/R) injury and deleterious inflammation, have been increasingly attributed to its modulation of redox balance. However, the precise molecular mech…
View article: Quantum Tunneling-Mediated Activation of Molecular Hydrogen by Semiquinone Radicals and Superoxide: Implications for Quantum Biology and Metal Catalyst-Free Redox Regulation
Quantum Tunneling-Mediated Activation of Molecular Hydrogen by Semiquinone Radicals and Superoxide: Implications for Quantum Biology and Metal Catalyst-Free Redox Regulation Open
The therapeutic effects of molecular hydrogen (H₂), particularly in ischemia-reperfusion (I/R) injury and deleterious inflammation, have been increasingly attributed to its modulation of redox balance. However, the precise molecular mechan…
View article: Chromosome-scale assembly with improved annotation provides insights into breed-wide genomic structure and diversity in domestic cats
Chromosome-scale assembly with improved annotation provides insights into breed-wide genomic structure and diversity in domestic cats Open
AnAms1.0 facilitates the discovery of novel genes related to normal and disease phenotypes in domestic cats. The analyzed data are publicly accessible on Cats-I (https://cat.annotation.jp/), which we established as a platform for accumulat…
View article: Generation of footprint-free, high-quality feline induced pluripotent stem cells using Sendai virus vector
Generation of footprint-free, high-quality feline induced pluripotent stem cells using Sendai virus vector Open
View article: Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors
Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors Open
View article: Negative Selection on a <i>SOD1</i> Mutation Limits Canine Degenerative Myelopathy While Avoiding Inbreeding
Negative Selection on a <i>SOD1</i> Mutation Limits Canine Degenerative Myelopathy While Avoiding Inbreeding Open
Several hundred disease-causing mutations are currently known in domestic dogs. Breeding management is therefore required to minimize their spread. Recently, genetic methods such as direct-to-consumer testing have gained popularity; howeve…
View article: Pet Animals Were Infected with SARS-CoV-2 from Their Owners Who Developed COVID-19: Case Series Study
Pet Animals Were Infected with SARS-CoV-2 from Their Owners Who Developed COVID-19: Case Series Study Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among pets owned by coronavirus disease 2019 (COVID-19) patients has been reported around the world. However, how often the animals are exposed to SARS-CoV-2 by their o…
View article: Negative selection on a<i>SOD1</i>mutation limits canine degenerative myelopathy while avoiding inbreeding
Negative selection on a<i>SOD1</i>mutation limits canine degenerative myelopathy while avoiding inbreeding Open
Several hundred disease-causing mutations are currently known in domestic dogs. Breeding management is therefore required to minimize their spread. Recently, genetic methods such as direct-to-consumer testing have gained popularity; howeve…
View article: Pilot evaluation of a single oral fecal microbiota transplantation for canine atopic dermatitis
Pilot evaluation of a single oral fecal microbiota transplantation for canine atopic dermatitis Open
View article: Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma
Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma Open
Histiocytic sarcoma (HS) is an incurable aggressive tumor, and no consensus has been made on the treatment due to its rare occurrence. Since dogs spontaneously develop the disease and several cell lines are available, they have been advoca…
View article: Genetic dissection of behavioral traits related to successful training of drug detection dogs
Genetic dissection of behavioral traits related to successful training of drug detection dogs Open
View article: A new detection method for canine and feline cancer using the olfactory system of nematodes
A new detection method for canine and feline cancer using the olfactory system of nematodes Open
View article: Comparison of Intestinal Microbiota Between Healthy and MMVD Chihuahuas Using 16S rRNA Gene Amplicon Sequencing
Comparison of Intestinal Microbiota Between Healthy and MMVD Chihuahuas Using 16S rRNA Gene Amplicon Sequencing Open
Myxomatous mitral valve disease (MMVD) is the most common cause of congestive heart failure in dogs, and although complications of MMVD to the lungs and kidneys have been identified, complications to the gut are less well understood. The i…
View article: Genetic dissection of behavioral traits related to successful training in drug-detection dogs
Genetic dissection of behavioral traits related to successful training in drug-detection dogs Open
Drug detection dogs play integral roles in society; however, the interplay between their behaviors and genetic characteristics remains uninvestigated. To profile the genetic traits associated with various behaviors related to the successfu…
View article: A New Detection Method for Canine and Feline Cancer Using the Olfactory System of Nematodes: A Pilot Study
A New Detection Method for Canine and Feline Cancer Using the Olfactory System of Nematodes: A Pilot Study Open
View article: Proof of Gene Doping in a Mouse Model with a Human Erythropoietin Gene Transferred Using an Adenoviral Vector
Proof of Gene Doping in a Mouse Model with a Human Erythropoietin Gene Transferred Using an Adenoviral Vector Open
Despite the World Anti-Doping Agency (WADA) ban on gene doping in the context of advancements in gene therapy, the risk of EPO gene-based doping among athletes is still present. To address this and similar risks, gene-doping tests are bein…
View article: Proof of Gene Doping in a Mouse Model with a Human Erythropoietin Gene Transferred Using an Adenoviral Vector
Proof of Gene Doping in a Mouse Model with a Human Erythropoietin Gene Transferred Using an Adenoviral Vector Open
The World Anti-Doping Agency (WADA) has prohibited gene doping in the context of progress in gene therapy. In addition, there is a risk of the EPO gene being applied in gene doping among athletes. Along with this, development of a gene-dop…
View article: DNA methylation landscape of 16 canine somatic tissues by methylation-sensitive restriction enzyme-based next generation sequencing
DNA methylation landscape of 16 canine somatic tissues by methylation-sensitive restriction enzyme-based next generation sequencing Open
View article: DNA Methylation Landscape of 16 Canine Somatic Tissues by Methylation-Sensitive Restriction Enzyme-Based Next Generation Sequencing
DNA Methylation Landscape of 16 Canine Somatic Tissues by Methylation-Sensitive Restriction Enzyme-Based Next Generation Sequencing Open
Background : DNA methylation plays important functions in gene expression regulation that is involved in individual development and various diseases. DNA methylation has been well studied in human and model organisms, but only limited data…
View article: Successful outcome after a single endoscopic fecal microbiota transplantation in a Shiba dog with non-responsive enteropathy during the treatment with chlorambucil
Successful outcome after a single endoscopic fecal microbiota transplantation in a Shiba dog with non-responsive enteropathy during the treatment with chlorambucil Open
A 7-year 6-month-old, castrated male Shiba dog presented with a 1-month history of lethargy, anorexia, vomiting, and frequent watery diarrhea. Weight loss, hypoalbuminemia, anemia, and leukocytosis were detected at the first visit. The dog…
View article: Genetic relationships and inbreeding levels among geographically distant populations of Felis catus from Japan and the United States
Genetic relationships and inbreeding levels among geographically distant populations of Felis catus from Japan and the United States Open
Pedigreed cats have traditionally been mated with close relatives, which increases the risks for inbreeding depression and genetic disorders. We evaluated the genome-wide population structure and the degree of inbreeding of 1022 cats, incl…
View article: Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial
Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial Open
Daily consumption of high H2 water improved the endothelial function of the arteries or arterioles assessed by the PAT test. The results suggest that the continuous consumption of high H2 water contributes to improved cardiovascular health.
View article: AnAms1.0: A high-quality chromosome-scale assembly of a domestic cat<i>Felis catus</i>of American Shorthair breed
AnAms1.0: A high-quality chromosome-scale assembly of a domestic cat<i>Felis catus</i>of American Shorthair breed Open
The domestic cat ( Felis catus ) is one of the most popular companion animals in the world. Comprehensive genomic resources will aid the development and application of veterinary medicine including to improve feline health, in particular, …
View article: Urinary Pharmacokinetic and Pharmacodynamic Profiles of Fosfomycin against Extended-Spectrum β-Lactamase-Producing Escherichia coli with Canine Ex Vivo Modeling: A Pilot Study
Urinary Pharmacokinetic and Pharmacodynamic Profiles of Fosfomycin against Extended-Spectrum β-Lactamase-Producing Escherichia coli with Canine Ex Vivo Modeling: A Pilot Study Open
Fosfomycin is a candidate drug for extended-spectrum β-lactamase (ESBL)-producing bacteria, but its efficacy is yet to be investigated in dogs. This study investigated the urinary pharmacokinetic/pharmacodynamic (PK/PD) profile of fosfomyc…
View article: Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential
Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential Open
Molecular hydrogen (H2) is recognized as a medical gas applicable to numerous diseases including neurodegenerative diseases, metabolic disorders, and rheumatoid arthritis. Although the efficacy of H2 is reportedly att…
View article: Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell lines
Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell lines Open
Exosomes are small extracellular vesicles released from almost all cell types, which play roles in cell-cell communication. Recent studies have suggested that microenvironmental crosstalk mediated by exosomes is an important factor in the …
View article: Effect of sevoflurane anesthesia on neuromuscular blockade produced by rocuronium infusion in dogs
Effect of sevoflurane anesthesia on neuromuscular blockade produced by rocuronium infusion in dogs Open
This study evaluated the effect of sevoflurane anesthesia on neuromuscular blockade with rocuronium in dogs. Six healthy beagle dogs were anesthetized four times with a minimum 14-day washout period. On each occasion, the dogs were adminis…
View article: Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell lines
Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell lines Open
Exosomes are small extracellular vesicles released from almost all cell types, which play roles in cell-cell communication. Recent studies have suggested that microenvironmental crosstalk mediated by exosomes is an important factor in the …
View article: Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq
Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq Open
View article: Additional file 1: of Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq
Additional file 1: of Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq Open
Table S1. Sequences of the oligonucleotide primers used for quantitative PCR. (XLSX 11 kb)