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View article: Mutation of the histone demethylase Gasc1 causes ASD-like symptoms in mice
Mutation of the histone demethylase Gasc1 causes ASD-like symptoms in mice Open
Taken together, our data suggest that histone demethylation plays a pivotal role in normal brain development and higher-order brain functions in both mice and humans.
View article: CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate
CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate Open
CUX2 gene encodes a transcription factor that controls neuronal proliferation, dendrite branching and synapse formation, locating at the epilepsy-associated chromosomal region 12q24 that we previously identified by a genome-wide associatio…
View article: CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate
CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate Open
CUX2 gene encodes a transcription factor that controls neuronal proliferation, dendrite branching and synapse formation, locating at the epilepsy-associated chromosomal region 12q24 that we previously identified by a genome-wide associatio…
View article: A recurrent <i>PJA1</i> variant in trigonocephaly and neurodevelopmental disorders
A recurrent <i>PJA1</i> variant in trigonocephaly and neurodevelopmental disorders Open
Objective Neurodevelopmental disorders (NDDs) often associate with epilepsy or craniofacial malformations. Recent large‐scale DNA analyses identified hundreds of candidate genes for NDDs, but a large portion of the cases still remain unexp…
View article: Increase in <scp>GFAP</scp>‐positive astrocytes in histone demethylase <scp>GASC</scp>1/<scp>KDM</scp>4C/<scp>JMJD</scp>2C hypomorphic mutant mice
Increase in <span>GFAP</span>‐positive astrocytes in histone demethylase <span>GASC</span>1/<span>KDM</span>4C/<span>JMJD</span>2C hypomorphic mutant mice Open
GASC 1, also known as KDM 4C/ JMJD 2C, is a histone demethylase for histone H3 lysine 9 (H3K9) and H3K36. In this study, we observed an increase of GFAP ‐positive astrocytes in the brain of Gasc1 hypomorphic mutant mice at 2–3 months of ag…