Gennaro Restaino
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View article: Ventricular volume asymmetry as a risk marker for heart failure and all-cause mortality in transfusion-dependent thalassemia
Ventricular volume asymmetry as a risk marker for heart failure and all-cause mortality in transfusion-dependent thalassemia Open
Aim: We measured the left-to-right ventricular volume ratio (LRVR) in a large cohort of patients with transfusion-dependent thalassemia (TDT) and assessed its cross-sectional correlations and its prognostic value in predicting heart failur…
View article: Prevalence and Correlates of Dilated and Non-Dilated Left Ventricular Cardiomyopathy in Transfusion-Dependent Thalassemia: Data from a National, Multicenter, Observational Registry
Prevalence and Correlates of Dilated and Non-Dilated Left Ventricular Cardiomyopathy in Transfusion-Dependent Thalassemia: Data from a National, Multicenter, Observational Registry Open
We investigated the prevalence, clinical characteristics, and prognostic role of dilated cardiomyopathy (DCM) and non-dilated left ventricular cardiomyopathy (NDLVC) in patients with transfusion-dependent β-thalassemia (β-TDT). We retrospe…
View article: Pancreatic Volume in Thalassemia: Determinants and Association with Alterations of Glucose Metabolism
Pancreatic Volume in Thalassemia: Determinants and Association with Alterations of Glucose Metabolism Open
Objectives: This study aimed to compare the pancreatic volume between beta-thalassemia major (β-TM) and beta-thalassemia intermedia (β-TI) patients and between thalassemia patients and healthy subjects and to determine the predictors of pa…
View article: Prognostic Role of Multiparametric Cardiac Magnetic Resonance in Neo Transfusion-Dependent Thalassemia
Prognostic Role of Multiparametric Cardiac Magnetic Resonance in Neo Transfusion-Dependent Thalassemia Open
Background: We prospectively evaluated the predictive value of multiparametric cardiac magnetic resonance (CMR) for cardiovascular complications in non-transfusion-dependent β-thalassemia (β-NTDT) patients who started regular transfusions …
View article: P1457: MOTION ABNORMALITIES IN THE LEFT VENTRICLE OF THALASSEMIA INTERMEDIA PATIENTS
P1457: MOTION ABNORMALITIES IN THE LEFT VENTRICLE OF THALASSEMIA INTERMEDIA PATIENTS Open
Topic: 27. Thalassemias Background: Motion abnormalities of the left ventricle (LV) have been reported in thalassemia major patients but no specific data is available for thalassemia intermedia (TI) patients. Motion abnormalities can be de…
View article: Multi-Parametric Cardiac Magnetic Resonance for Prediction of Heart Failure Death in Thalassemia Major
Multi-Parametric Cardiac Magnetic Resonance for Prediction of Heart Failure Death in Thalassemia Major Open
We assessed the prognostic value of multiparametric cardiovascular magnetic resonance (CMR) in predicting death from heart failure (HF) in thalassemia major (TM). We considered 1398 white TM patients (30.8 ± 8.9 years, 725 women) without a…
View article: Preoperative Tumor Texture Analysis on MRI for High-Risk Disease Prediction in Endometrial Cancer: A Hypothesis-Generating Study
Preoperative Tumor Texture Analysis on MRI for High-Risk Disease Prediction in Endometrial Cancer: A Hypothesis-Generating Study Open
Objective: To develop and validate magnetic resonance (MR) imaging-based radiomics models for high-risk endometrial cancer (EC) prediction preoperatively, to be able to estimate deep myometrial invasion (DMI) and lymphovascular space invas…
View article: Impact of the COVID-19 pandemic in the MR availability for iron overloaded patients
Impact of the COVID-19 pandemic in the MR availability for iron overloaded patients Open
Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): The E-MIOT project receives “no-profit support” from industrial sponsorships (Chiesi Farmaceutici S.p.A. and Bayer). Background The T2* magnetic res…
View article: Multiparametric cardiac magnetic resonance assessmenti in sickle-beta-thalassemia
Multiparametric cardiac magnetic resonance assessmenti in sickle-beta-thalassemia Open
Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): The MIOT project receives “no-profit support” from industrial sponsorships (Chiesi Farmaceutici S.p.A., ApoPharma Inc.). Background. Sickle β-thalas…
View article: PS1572 HEART DISEASE AND PANCREATIC IRON IN THALASSEMIA MAJOR
PS1572 HEART DISEASE AND PANCREATIC IRON IN THALASSEMIA MAJOR Open
Background: Some preliminary data have postulated a correlation between pancreatic iron overload and heart iron and function in thalassemia major (TM) patients. Aims: In the present multicenter study we explored systematically the link bet…
View article: MRI multicentre prospective survey in thalassaemia major patients treated with deferasirox <i>versus</i> deferiprone and desferrioxamine
MRI multicentre prospective survey in thalassaemia major patients treated with deferasirox <i>versus</i> deferiprone and desferrioxamine Open
Summary We prospectively assessed the efficacy of deferasirox versus deferiprone or desferrioxamine as monotherapy in thalassaemia major (TM) patients by magnetic resonance imaging (MRI). We selected the patients enrolled in the Myocardial…
View article: 4094MRI prospective survey on heart and liver iron and cardiac function in thalassemia major patients treated with Deferasirox versus Deferiprone and Desferrioxamine in monotherapy
4094MRI prospective survey on heart and liver iron and cardiac function in thalassemia major patients treated with Deferasirox versus Deferiprone and Desferrioxamine in monotherapy Open
Background: An acute myocardial infarction (MI) triggers potent inflammatory responses that amplify the ischemic myocardial damage and promote heart failure.The alarmin complex S100A8/9 is highly upregulated locally and systemically after …