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View article: The astrocytic ensemble acts as a multiday trace to stabilize memory
The astrocytic ensemble acts as a multiday trace to stabilize memory Open
Recalled memories become transiently labile and require stabilization 1–3 . The mechanism for stabilizing memories of survival-critical experiences, which are often emotionally salient and repeated, remains unclear 4 . Here we identify an …
View article: Right Ventricular Systolic and Diastolic Parameters on the Basis of Pressure-Volume Loop Theory in Patients With Heart Failure
Right Ventricular Systolic and Diastolic Parameters on the Basis of Pressure-Volume Loop Theory in Patients With Heart Failure Open
RV waveform evaluation based on PV loop theory was effective in predicting prognosis in HF patients, irrespective of LVEF.
View article: Epinephrine and Depletion of Female Sex Hormone Exacerbate the Pathology of Obesity-Induced Cardiac Phenotype
Epinephrine and Depletion of Female Sex Hormone Exacerbate the Pathology of Obesity-Induced Cardiac Phenotype Open
Heart failure is associated with poor quality of life and mortality, and the prevalence of heart failure is increasing together with aging of the population. Approximately 50% of patients with heart failure present as HFpEF, and the surviv…
View article: In vivo effects of cardiomyocyte-specific β-1 blockade on afterload- and frequency-dependent cardiac performance
In vivo effects of cardiomyocyte-specific β-1 blockade on afterload- and frequency-dependent cardiac performance Open
Although the benefits of β-1 adrenergic receptor (ADRB1) blockade to cardiovascular disease are established, in vivo role for cardiomyocyte ADRB1 remains undetermined. Generating cardiomyocyte-specific ADRB1 knockout mice, we show that ADR…
View article: Endothelial oestrogen–myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload
Endothelial oestrogen–myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload Open
Aims Oestrogen exerts beneficial cardiovascular effects by binding to specific receptors on various cells to activate nuclear and non-nuclear actions. Oestrogen receptor α (ERα) non-nuclear signalling confers protection against heart failu…
View article: PGC-1α–mediated angiogenesis prevents pulmonary hypertension in mice
PGC-1α–mediated angiogenesis prevents pulmonary hypertension in mice Open
Pulmonary hypertension (PH) is a life-threatening disease characterized by a progressive narrowing of pulmonary arterioles. Although VEGF is highly expressed in lung of patients with PH and in animal PH models, the involvement of angiogene…
View article: Effect of renal function under left ventricular assist device support on the cardiac function and clinical events after heart transplantation
Effect of renal function under left ventricular assist device support on the cardiac function and clinical events after heart transplantation Open
Aim We investigated the effects of pre‐transplantation renal dysfunction under left ventricular assisted device (LVAD) support on post‐transplantation cardiac function, and patient prognosis after heart transplantation (HTx). Method All pa…
View article: A Case of Uncommon Quadricuspid Aortic Valve Stenosis Associated With Noonan Syndrome and Acromegaly
A Case of Uncommon Quadricuspid Aortic Valve Stenosis Associated With Noonan Syndrome and Acromegaly Open
Quadricuspid aortic valve (QAV) is a congenital aortic valve malformation usually associated with aortic regurgitation. We encountered a patient with Noonan syndrome (NS) who had severe QAV stenosis caused by degenerative aortic cusps with…
View article: A new assessment method for right ventricular diastolic function using right heart catheterization by pressure‐volume loop
A new assessment method for right ventricular diastolic function using right heart catheterization by pressure‐volume loop Open
Diastolic stiffness coefficient (β) and end‐diastolic elastance (Eed) are ventricular‐specific diastolic parameters. However, the diastolic function of right ventricle had not been investigated sufficiently due to the lack of established e…
View article: Prognostic value of follow-up vasoreactivity test in pulmonary arterial hypertension
Prognostic value of follow-up vasoreactivity test in pulmonary arterial hypertension Open
Follow-up vasoreactivity test after treatment could contribute to the detection of high-risk subgroups who might need careful monitoring and referral for lung transplantation.
View article: Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury
Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury Open
View article: The Genetic Background of Peripheral Pulmonary Artery Stenosis
The Genetic Background of Peripheral Pulmonary Artery Stenosis Open
末梢型肺動脈狭窄症(PPS)は末梢肺動脈に狭窄や閉塞を呈する疾患であり,先天性疾患を合併しない純型PPSの若年成人患者の報告が増えている。最近,もやもや病の疾患感受性遺伝子多型(RNF213遺伝子;p.Arg4810Lys)が,PPSや腎動脈狭窄,アテローム性動脈硬化頭蓋内狭窄などのさまざまな血管疾患の発症・進展に関与していることが明らかとなった。本稿では,当院でのPPS診療経験を踏まえ,この新たな疾患概念(RNF213 vasculopathy)に関する最新の知見を紹介す…
View article: Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling
Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling Open
View article: Cyclic GMP and PKG Signaling in Heart Failure
Cyclic GMP and PKG Signaling in Heart Failure Open
Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by two intrinsic pathways: nitric oxide (NO)-soluble GC and natriure…
View article: Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System
Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System Open
Great progress has been made in the understanding of the pathophysiology of cardiovascular diseases (CVDs), and this has improved the prevention and prognosis of CVDs. However, while sex differences in CVDs have been well documented and st…
View article: Preexisting heart failure with reduced ejection fraction attenuates renal fibrosis after ischemia reperfusion via sympathetic activation
Preexisting heart failure with reduced ejection fraction attenuates renal fibrosis after ischemia reperfusion via sympathetic activation Open
View article: Endothelial-specific Ablation of Non-nuclear Estrogen Receptor alpha Signaling Deteriorates Vascular Remodelling Response
Endothelial-specific Ablation of Non-nuclear Estrogen Receptor alpha Signaling Deteriorates Vascular Remodelling Response Open
Background and introduction The difference in cardiovascular disease risk between age-matched women and men narrows as transition through menopause in observational studies. Estrogen exerts complex physiological effects via its non-nuclear…
View article: Nuclear GAPDH cascade mediates stress-dependent pathological cardiac growth
Nuclear GAPDH cascade mediates stress-dependent pathological cardiac growth Open
Here we report that stress-induced nuclear translocation of GAPDH mediates heart hypertrophy via Brahma-Related-Gene-1 (BRG1)-associated chromatin remodelling. In response to pressure overload elicited by transverse aortic constriction, we…
View article: Usefulness of central venous saturation as a predictor of thiamine deficiency in critically ill patients: a case report
Usefulness of central venous saturation as a predictor of thiamine deficiency in critically ill patients: a case report Open
View article: Cardiac Resynchronization Therapy in Patients with Ebstein's Anomaly
Cardiac Resynchronization Therapy in Patients with Ebstein's Anomaly Open
Ebstein's anomaly is a rare congenital heart disease characterized by apical displacement of the septal and posterior tricuspid valve leaflets. It is often complicated with left ventricular (LV) dysfunction as well as right-sided abnormali…