Genxi Zhang
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View article: Whole transcriptome sequencing reveals the functional regulation of chicken reproduction by lncRNAs, miRNAs, and mRNAs across the hypothalamus-pituitary-ovary axis
Whole transcriptome sequencing reveals the functional regulation of chicken reproduction by lncRNAs, miRNAs, and mRNAs across the hypothalamus-pituitary-ovary axis Open
The hypothalamic–pituitary-ovarian (HPO) axis serves as the pivotal regulatory system governing reproduction in chickens. This study performed whole transcriptome sequencing on hypothalamus, pituitary, and ovarian tissues of Bian chickens …
View article: Association Analysis of the FTO Gene Polymorphisms with Growth and Carcass Traits of Heying Black Chicken and Tissue Expression Profile
Association Analysis of the FTO Gene Polymorphisms with Growth and Carcass Traits of Heying Black Chicken and Tissue Expression Profile Open
Fat volume and obesity-related genes (e.g., the FTO gene) are important candidate genes affecting energy metabolism. Single nucleotide polymorphisms (SNPs) in the FTO gene are associated with carcass, growth and meat quality traits of pigs…
View article: Aptamers for aflatoxin M1: from aptasensing technology to commercialization
Aptamers for aflatoxin M1: from aptasensing technology to commercialization Open
Aflatoxin M1 (AFM1) contamination in milk and dairy products poses a significant global concern due to its severe health risks to humans. Sensitive and specific detection of AFM1 has emerged as the most effective strategy for mitigating th…
View article: Metagenomic Analysis Reveals the Characteristics of Cecal Microbiota in Chickens with Different Levels of Resistance During Recovery from Eimeria tenella Infection
Metagenomic Analysis Reveals the Characteristics of Cecal Microbiota in Chickens with Different Levels of Resistance During Recovery from Eimeria tenella Infection Open
Coccidiosis, caused by Eimeria protozoa, is a severe intestinal parasitic disease that results in substantial economic losses to the global poultry industry annually. The gut microbiota plays a crucial role in host health, metabolism, immu…
View article: Confirmation of enrofloxacin, ofloxacin, sarafloxacin and danofloxacin residues in poultry meat and pork via LLE-SPE-GC–MS/MS coupled with derivatization treatment
Confirmation of enrofloxacin, ofloxacin, sarafloxacin and danofloxacin residues in poultry meat and pork via LLE-SPE-GC–MS/MS coupled with derivatization treatment Open
A gas chromatography-tandem mass technique for simultaneous determination of four fluoroquinolone residues in poultry meat and pork was perfect. Trimethylsilyl diazomethane was applied as the derivatizing agent coupled with liquid-liquid a…
View article: miRNA-34a-5p inhibits chicken myoblasts proliferation and differentiation via NOTCH1 inhibition
miRNA-34a-5p inhibits chicken myoblasts proliferation and differentiation via NOTCH1 inhibition Open
The growth performance of chickens contributes to the sustainable development of the broiler industry, and skeletal muscle development is particularly crucial for chicken production. MicroRNAs (miRNAs) are noncoding RNAs that can participa…
View article: RNA-seq reveals changes in the transcriptome of the breast muscle of adult female chickens in response to heat stress
RNA-seq reveals changes in the transcriptome of the breast muscle of adult female chickens in response to heat stress Open
Our findings will enrich the research on heat stress resistance in chicken skeletal muscle, while also providing a theoretical basis for the genetic improvement of heat stress resistance in chickens.
View article: A Comparison of the Cecal Microbiota between the Infection and Recovery Periods in Chickens with Different Susceptibilities to Eimeria tenella
A Comparison of the Cecal Microbiota between the Infection and Recovery Periods in Chickens with Different Susceptibilities to Eimeria tenella Open
To investigate the effect of Eimeria tenella (E. tenella) infection on the cecal microbiota, resistant and susceptible families were screened out based on the coccidiosis resistance evaluation indexes after E. tenella infection. Subsequent…
View article: Transcriptome Analysis of Hypothalamic-Pituitary-Ovarian Axis Reveals circRNAs Related to Egg Production of Bian Chicken
Transcriptome Analysis of Hypothalamic-Pituitary-Ovarian Axis Reveals circRNAs Related to Egg Production of Bian Chicken Open
The hypothalamic–pituitary–ovarian (HPO) axis plays a pivotal role in the regulation of egg production in chickens. In addition to the traditional understanding of the HPO axis, emerging research highlights the significant role of circRNAs…
View article: RNA-Seq reveals transcriptome changes to heat stress in the breast muscle of adult female chickens
RNA-Seq reveals transcriptome changes to heat stress in the breast muscle of adult female chickens Open
Background Heat stress has caused significant impacts on the poultry industry globally. Tianjin-monkey Chicken (TM) is a local naked neck chicken genetic resource in China, characterized by its heat stress resistance due to a low feather c…
View article: Quantitative analysis of erythromycin, its major metabolite and clarithromycin in chicken tissues and eggs via QuEChERS extraction coupled with ultrahigh-performance liquid chromatography-tandem mass spectrometry
Quantitative analysis of erythromycin, its major metabolite and clarithromycin in chicken tissues and eggs via QuEChERS extraction coupled with ultrahigh-performance liquid chromatography-tandem mass spectrometry Open
View article: Development of a QuEChERS–HPLC–FLD Procedure for the Simultaneous Detection of Residues of Florfenicol, Its Metabolite Florfenicol Amine, and Three Fluoroquinolones in Eggs
Development of a QuEChERS–HPLC–FLD Procedure for the Simultaneous Detection of Residues of Florfenicol, Its Metabolite Florfenicol Amine, and Three Fluoroquinolones in Eggs Open
A method utilizing high-performance liquid chromatography-fluorescence detection (HPLC–FLD) has been developed and refined for the simultaneous detection of florfenicol (FF) and its metabolite florfenicol amine (FFA) along with three fluor…
View article: The Innovative Method Involving Pre-Column Derivation Oftrimethylsilyl Diazomethane for the Evaluation of Enrofloxacin and Ofloxacin Residues in Eggs and Milk Products by Gc-Ms/Ms
The Innovative Method Involving Pre-Column Derivation Oftrimethylsilyl Diazomethane for the Evaluation of Enrofloxacin and Ofloxacin Residues in Eggs and Milk Products by Gc-Ms/Ms Open
View article: Gc-Ms/Ms Combined with Sample Pretreatment of Lle-Spe for Simultaneous Analysis of Enrofloxacin and Ofloxacin Residues in Chicken Tissues and Pork
Gc-Ms/Ms Combined with Sample Pretreatment of Lle-Spe for Simultaneous Analysis of Enrofloxacin and Ofloxacin Residues in Chicken Tissues and Pork Open
View article: Quantitative Analysis of Decoquinate Residues in Hen Eggs through Derivatization-Gas Chromatography Tandem Mass Spectrometry
Quantitative Analysis of Decoquinate Residues in Hen Eggs through Derivatization-Gas Chromatography Tandem Mass Spectrometry Open
A novel precolumn derivatization-gas chromatography tandem mass spectrometry (GC-MS/MS) method was developed to detect and confirm the presence of decoquinate residues in eggs (whole egg, albumen and yolk). Liquid-liquid extraction (LLE) a…
View article: Identification of metabolite biomarkers in Salmonella enteritidis-contaminated chickens using UHPLC-QTRAP-MS-based targeted metabolomics
Identification of metabolite biomarkers in Salmonella enteritidis-contaminated chickens using UHPLC-QTRAP-MS-based targeted metabolomics Open
This study aimed to characterize the metabolic profile of Salmonella enteritidis (S. enteritidis) in chicken matrix and to identify metabolic biomarkers of S. enteritidis in chicken. The UHPLC-QTRAP-MS high-throughput …
View article: miR-460b-5p promotes proliferation and differentiation of chicken myoblasts and targets RBM19 gene
miR-460b-5p promotes proliferation and differentiation of chicken myoblasts and targets RBM19 gene Open
View article: Exploration of Potential Target Genes of miR-24-3p in Chicken Myoblasts by Transcriptome Sequencing Analysis
Exploration of Potential Target Genes of miR-24-3p in Chicken Myoblasts by Transcriptome Sequencing Analysis Open
Broiler skeletal muscle growth is significantly influenced by miRNAs. Our earlier research demonstrated that miR-24-3p significantly suppressed the proliferation of chicken myoblasts while promoting their differentiation. The purpose of th…
View article: High-fat diet-induced gut microbiota alteration promotes lipogenesis by butyric acid/miR-204/ACSS2 axis in chickens
High-fat diet-induced gut microbiota alteration promotes lipogenesis by butyric acid/miR-204/ACSS2 axis in chickens Open
View article: Comprehensive analysis of gut microbiome and host transcriptome in chickens after Eimeria tenella infection
Comprehensive analysis of gut microbiome and host transcriptome in chickens after Eimeria tenella infection Open
Background Coccidiosis is an intestinal parasitic disease caused by Eimeria protozoa, which endangers the health and growth of animals, and causes huge economic losses to the poultry industry worldwide every year. Studies have shown that p…
View article: Integrated Metabolomic and Transcriptomic Analysis Reveals Potential Gut-Liver Crosstalks in the Lipogenesis of Chicken
Integrated Metabolomic and Transcriptomic Analysis Reveals Potential Gut-Liver Crosstalks in the Lipogenesis of Chicken Open
Growing evidence has shown the involvement of the gut–liver axis in lipogenesis and fat deposition. However, how the gut crosstalk with the liver and the potential role of gut–liver crosstalk in the lipogenesis of chicken remains largely u…
View article: Qualitative and Quantitative Determination of Decoquinate in Chicken Tissues by Gas Chromatography Tandem Mass Spectrometry
Qualitative and Quantitative Determination of Decoquinate in Chicken Tissues by Gas Chromatography Tandem Mass Spectrometry Open
A novel precolumn derivatization–GC-MS/MS method was developed for the determination of decoquinate residues in chicken tissues (muscle, liver, and kidney). The samples were extracted and purified by liquid–liquid extraction combined with …
View article: Genome-Wide Analysis of the KLF Gene Family in Chicken: Characterization and Expression Profile
Genome-Wide Analysis of the KLF Gene Family in Chicken: Characterization and Expression Profile Open
The kruppel-like factor (KLF) gene family is a group of transcription factors containing highly conserved zinc-finger motifs, which play a crucial role in cell proliferation and differentiation. Chicken has been widely used as a model anim…
View article: Identification of Metabolite Biomarkers in Salmonella Enteritidis Contaminated Chickens Using Uhplc-Qtrap-Ms-Based Targeted Metabolomics
Identification of Metabolite Biomarkers in Salmonella Enteritidis Contaminated Chickens Using Uhplc-Qtrap-Ms-Based Targeted Metabolomics Open
View article: Transcriptome Sequencing Analysis of circRNA in Skeletal Muscle between Fast- and Slow-Growing Chickens at Embryonic Stages
Transcriptome Sequencing Analysis of circRNA in Skeletal Muscle between Fast- and Slow-Growing Chickens at Embryonic Stages Open
Skeletal muscle growth has always been the focus of the broiler industry, and circRNAs play a significant role in this process. We collected leg muscles of slow- and fast-growing Bian chicken embryos in the study at 14 (S14 and F14) and 20…
View article: Prediction of the Effect of Methylation in the Promoter Region of ZP2 Gene on Egg Production in Jinghai Yellow Chickens
Prediction of the Effect of Methylation in the Promoter Region of ZP2 Gene on Egg Production in Jinghai Yellow Chickens Open
Egg production in chickens is a quantitative trait. The aim of this study was to investigate the effect of promoter methylation of the Zona pellucida 2 (ZP2) gene on egg production. Real-time fluorescence quantification showed that the exp…
View article: Identification of miRNA–mRNA Networks Associated with Pigeon Skeletal Muscle Development and Growth
Identification of miRNA–mRNA Networks Associated with Pigeon Skeletal Muscle Development and Growth Open
The growth and development of skeletal muscle determine the productivity of pigeon meat production, and miRNA plays an important role in the growth and development of this type of muscle. However, there are few reports regarding miRNA regu…
View article: Long noncoding RNA profiling reveals that LncRNA BTN3A2 inhibits the host inflammatory response to Eimeria tenella infection in chickens
Long noncoding RNA profiling reveals that LncRNA BTN3A2 inhibits the host inflammatory response to Eimeria tenella infection in chickens Open
Coccidiosis is a widespread parasitic disease that causes serious economic losses to the poultry industry every year. Long noncoding RNAs (lncRNAs) play important roles in transcriptional regulation and are involved in a variety of disease…
View article: miRNA-10a-5p Targeting the BCL6 Gene Regulates Proliferation, Differentiation and Apoptosis of Chicken Myoblasts
miRNA-10a-5p Targeting the BCL6 Gene Regulates Proliferation, Differentiation and Apoptosis of Chicken Myoblasts Open
Proliferation, differentiation, and apoptosis are three essential stages in cell development, and miRNAs can achieve extensive regulation of cellular developmental processes by repressing the expression of target genes. According to our pr…
View article: miRNA-seq analysis in skeletal muscle of chicken and function exploration of miR-24-3p
miRNA-seq analysis in skeletal muscle of chicken and function exploration of miR-24-3p Open