Genzo Iguchi
YOU?
Author Swipe
View article: SAT-067 Evaluating Drug-Induced Effects on Cell Viability in Acromegaly Using a Patient-Derived 3D Culture Model
SAT-067 Evaluating Drug-Induced Effects on Cell Viability in Acromegaly Using a Patient-Derived 3D Culture Model Open
Disclosure: Y. Tsujimoto: None. A. Ishida: None. H. Shichi: None. N. Yamamoto: None. Y. Motomura: None. Y. Oi-Yo: None. Y. Sasaki: None. M. Suzuki: None. S. Urai: None. H. Bando: None. M. Yamamoto: None. M. Takahashi: None. G. Iguchi: None…
View article: SUN-069 The role of FTO-mediated m6A modification in ACTH regulation
SUN-069 The role of FTO-mediated m6A modification in ACTH regulation Open
Disclosure: N. Yamamoto: None. Y. Tsujimoto: None. H. Shichi: None. S. Urai: None. M. Suzuki: None. H. Bando: None. M. Yamamoto: None. Y. Motomura: None. Y. Sasaki: None. Y. Oi-Yo: None. M. Takahashi: None. G. Iguchi: None. D. Motooka: Non…
View article: SAT-067 Evaluating Drug-Induced Effects on Cell Viability in Acromegaly Using a Patient-Derived 3D Culture Model
SAT-067 Evaluating Drug-Induced Effects on Cell Viability in Acromegaly Using a Patient-Derived 3D Culture Model Open
Disclosure: Y. Tsujimoto: None. A. Ishida: None. H. Shichi: None. N. Yamamoto: None. Y. Motomura: None. Y. Oi-Yo: None. Y. Sasaki: None. M. Suzuki: None. S. Urai: None. H. Bando: None. M. Yamamoto: None. M. Takahashi: None. G. Iguchi: None…
View article: Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid
Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid Open
View article: Glucocorticoid Resistance Syndrome as a Hidden Cause of Nonneoplastic Hypercortisolism
Glucocorticoid Resistance Syndrome as a Hidden Cause of Nonneoplastic Hypercortisolism Open
Cases of hypercortisolemia without physical signs of Cushing's syndrome (CS), suggestive of nonneoplastic hypercortisolism (NNH), often remain partially unexplained. We present a unique case that was initially misdiagnosed as ACTH-dependen…
View article: Body mass index and metabolic complications in individuals with treatment-naïve acromegaly
Body mass index and metabolic complications in individuals with treatment-naïve acromegaly Open
Body mass index (BMI) can be used to define obesity-a global health concern and a risk factor for various complications. However, it does not accurately represent body composition. Furthermore, a correlation between BMI and the frequency o…
View article: Metyrapone single administration, as a possible predictive tool of its dosage and timing in Cushing’s syndrome
Metyrapone single administration, as a possible predictive tool of its dosage and timing in Cushing’s syndrome Open
Metyrapone is commonly used in the initial management of Cushing’s syndrome to reduce hypercortisolemia, but its optimal dosage and timing can vary significantly between patients. Currently, there are limited guidelines on adjustment metho…
View article: 6776 A case of non-neoplastic hypercortisolism leading to the diagnosis of glucocorticoid resistance syndrome due to a novel NR3C1 variant
6776 A case of non-neoplastic hypercortisolism leading to the diagnosis of glucocorticoid resistance syndrome due to a novel NR3C1 variant Open
Disclosure: N. Yamamoto: None. N. Kido: None. H. Bando: None. M. Yamamoto: None. S. Urai: None. Y. Tsujimoto: None. Y. Ohmachi: None. Y. Motomoura: None. Y. Oi-Yo: None. Y. Sasaki: None. M. Suzuki: None. M. Takahashi: None. G. Iguchi: None…
View article: 6965 Discrepancy As A Diagnostic Dilemma Between Patient-Reported And Physician-Reported Symptoms Of Cushing's Syndrome
6965 Discrepancy As A Diagnostic Dilemma Between Patient-Reported And Physician-Reported Symptoms Of Cushing's Syndrome Open
Disclosure: Y. Motomura: None. S. Urai: None. H. Bando: None. M. Yamamoto: None. M. Suzuki: None. N. Yamamoto: None. G. Iguchi: None. W. Ogawa: None. H. Fukuoka: None. Background: The early diagnosis and immediate treatment of Cushing’s sy…
View article: Acquired isolated ACTH deficiency co-occurrence with breast cancer irrespective of paraneoplastic syndrome: coincidence or inevitability
Acquired isolated ACTH deficiency co-occurrence with breast cancer irrespective of paraneoplastic syndrome: coincidence or inevitability Open
Summary A 52-year-old female patient with breast cancer presented with a history of fatigue and malaise 1 year prior. She was diagnosed with isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) on endocrinological examination. Her …
View article: Diagnostic dilemma in Cushing’s syndrome: discrepancy between patient-reported and physician-assessed manifestations
Diagnostic dilemma in Cushing’s syndrome: discrepancy between patient-reported and physician-assessed manifestations Open
View article: Fluctuations in plasma adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis
Fluctuations in plasma adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis Open
Immune checkpoint inhibitor (ICI)-related hypophysitis (RH) is a common immune-related adverse event. The early detection of ICI-RH prevents life-threatening adrenal insufficiency. However, good predictors of secondary adrenal insufficienc…
View article: Fluctuations in serum adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis
Fluctuations in serum adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis Open
Background Immune checkpoint inhibitor (ICI)-related hypophysitis (RH) is a common immune-related adverse event. The early detection of ICI-RH prevents life-threatening adrenal insufficiency. However, good predictors of secondary adrenal i…
View article: Paraneoplastic isolated adrenocorticotropic hormone deficiency revealed after immune checkpoint inhibitors therapy: new insights into anti-corticotroph antibody
Paraneoplastic isolated adrenocorticotropic hormone deficiency revealed after immune checkpoint inhibitors therapy: new insights into anti-corticotroph antibody Open
Introduction A recently discovered facet of paraneoplastic adrenocorticotropic hormone (ACTH) deficiency exists in two forms: a paraneoplastic spontaneous isolated ACTH deficiency (IAD) and an immune checkpoint inhibitor (ICI)-related hypo…
View article: The combination of doxazosin and metyrosine as a preoperative treatment for pheochromocytomas and paragangliomas
The combination of doxazosin and metyrosine as a preoperative treatment for pheochromocytomas and paragangliomas Open
Purpose : Preoperative medical management is critical to prevent intraoperative cardiovascular complications in patients with pheochromocytomas and paragangliomas (PPGLs). Initial treatment involves α-adrenergic receptor blockers. However,…
View article: SAT141 A Case Of Non-islet Cell Tumor Hypoglycemia Which Was Ameliorated By Pazopanib Treatment
SAT141 A Case Of Non-islet Cell Tumor Hypoglycemia Which Was Ameliorated By Pazopanib Treatment Open
Disclosure: N. Yamamoto: None. M. Yamamoto: None. N. Kiyota: None. Y. Inaba: None. K. Kanie: None. S. Urai: None. M. Suzuki: None. Y. Sasaki: None. Y. Oi: None. Y. Tsujimoto: None. Y. Motomura: None. Y. Ohmachi: None. H. Bando: None. G. Ig…
View article: Combined Hypophysitis and Type 1 Diabetes Mellitus Related to Immune Checkpoint Inhibitors
Combined Hypophysitis and Type 1 Diabetes Mellitus Related to Immune Checkpoint Inhibitors Open
Context The occurrence of multiple endocrinopathies due to immune checkpoint inhibitors (ICIs) is a relatively common adverse event. However, the occurrence of a combination of hypophysitis and type 1 diabetes mellitus (T1DM) is extremely …
View article: Case report: Late middle-aged features of FAM111A variant, Kenny–Caffey syndrome type 2-suggestive symptoms during a long follow-up
Case report: Late middle-aged features of FAM111A variant, Kenny–Caffey syndrome type 2-suggestive symptoms during a long follow-up Open
Kenny–Caffey syndrome type 2 (KCS2) is an extremely rare skeletal disorder involving hypoparathyroidism and short stature. It has an autosomal dominant pattern of inheritance and is caused by variants in the FAM111 trypsin-like peptidase A…
View article: ODP329 Long-term Effect of Daily Growth Hormone Replacement Therapy on Glucose Tolerance in Adult growth Hormone Deficiency
ODP329 Long-term Effect of Daily Growth Hormone Replacement Therapy on Glucose Tolerance in Adult growth Hormone Deficiency Open
Background Growth hormone replacement therapy (GHRT) in adults with growth hormone deficiency (AGHD) has shown to improve body composition, lipid and bone metabolism, and quality of life (QOL), but its effect on glucose tolerance can be bi…
View article: Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state
Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state Open
View article: Novel genes and variants associated with congenital pituitary hormone deficiency in the era of next-generation sequencing
Novel genes and variants associated with congenital pituitary hormone deficiency in the era of next-generation sequencing Open
Combined pituitary hormone deficiency (CPHD) is not a rare disorder, with a frequency of approximately 1 case per 4,000 live births. However, in most cases, a genetic diagnosis is not available. Furthermore, the diagnosis is challenging be…
View article: Survey of glucocorticoid dose escalation in patients with adrenal insufficiency during the peri-COVID-19 vaccination period
Survey of glucocorticoid dose escalation in patients with adrenal insufficiency during the peri-COVID-19 vaccination period Open
There is uncertainty regarding the need for COVID-19 peri-vaccination glucocorticoid coverage in patients with adrenal insufficiency. In this survey conducted in a single tertiary medical institution, 167 consecutive outpatients taking phy…
View article: Author Correction: Bilateral adrenal uptake of 123I MIBG scintigraphy with mild catecholamine elevation, the diagnostic dilemma, and its characteristics
Author Correction: Bilateral adrenal uptake of 123I MIBG scintigraphy with mild catecholamine elevation, the diagnostic dilemma, and its characteristics Open
View article: Bilateral adrenal uptake of 123I MIBG scintigraphy with mild catecholamine elevation, the diagnostic dilemma, and its characteristics
Bilateral adrenal uptake of 123I MIBG scintigraphy with mild catecholamine elevation, the diagnostic dilemma, and its characteristics Open
View article: Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus
Relation between the insulin lowering rate and changes in bone mineral density: Analysis among subtypes of type 1 diabetes mellitus Open
Aims/Introduction The bone mineral density in patients with type 1 diabetes mellitus is reduced due to impaired insulin secretion. However, it is unclear whether the rate of bone mineral density reduction is affected by the type 1 diabetes…
View article: Responsiveness to DDAVP in Cushing’s disease is associated with USP8 mutations through enhancing AVPR1B promoter activity
Responsiveness to DDAVP in Cushing’s disease is associated with USP8 mutations through enhancing AVPR1B promoter activity Open
We found that the responsiveness of ACTH to DDAVP in CD was greater in tumors with USP8 mutations. The present data suggest that USP8 mutations upregulate the AVPR1B promoter activity. Additionally, we showed that the DDAVP test can predic…
View article: The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment
The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment Open
Context With the increasing number of older patients with acromegaly, it is important to understand the effects of aging on the quality of life (QoL) in acromegaly. Objective To investigate the factors associated with the QoL of older acro…
View article: Rostral Hypothalamic Differentiation With Minimal Exogenous Signals in Human Naive Induced Pluripotent Stem Cells
Rostral Hypothalamic Differentiation With Minimal Exogenous Signals in Human Naive Induced Pluripotent Stem Cells Open
Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disease of vasopressin (AVP) neurons. Studies in mouse in vivo models indicate that accumulation of mutant AVP prehormone is associated with FNDI pathology. However, stu…
View article: Mechanistic insights into immune checkpoint inhibitor-related hypophysitis: a form of paraneoplastic syndrome
Mechanistic insights into immune checkpoint inhibitor-related hypophysitis: a form of paraneoplastic syndrome Open
View article: Two Cases of Anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome
Two Cases of Anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome Open
Background: Anti-pituitary-specific transcription factor 1 (PIT-1) hypophysitis (anti-PIT-1 antibody syndrome) is a newly defined clinical entity, demonstrating an adult-onset hypopituitarism, and is a thymoma-associated autoimmune disease…