Geoffrey Schembri
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View article: CTNI-25. MULTI-SITE, PROSPECTIVE TRIAL EVALUATING FET-PET IN GLIOBLASTOMA (FIG) STUDY (TROG 18.06): CENTRAL NUCLEAR MEDICINE AND RADIATION ONCOLOGY REVIEW OF FET-PET BIOLOGIC TARGET VOLUME DELINEATION FOR RADIATION PLANNING
CTNI-25. MULTI-SITE, PROSPECTIVE TRIAL EVALUATING FET-PET IN GLIOBLASTOMA (FIG) STUDY (TROG 18.06): CENTRAL NUCLEAR MEDICINE AND RADIATION ONCOLOGY REVIEW OF FET-PET BIOLOGIC TARGET VOLUME DELINEATION FOR RADIATION PLANNING Open
BACKGROUND The prospective multi-site trial evaluating O-(2-[18F]-fluoroethyl)-L-tyrosine Positron Emission Tomography (FET-PET) in Glioblastoma (FIG) study is currently recruiting. This abstract aims to evaluate the impact of full central…
View article: The utility of 68Ga-DOTATATE and 18F-FDG PET/CT in predicting the response to tyrosine kinase inhibitors in patients with advanced medullary thyroid cancer
The utility of 68Ga-DOTATATE and 18F-FDG PET/CT in predicting the response to tyrosine kinase inhibitors in patients with advanced medullary thyroid cancer Open
Background Tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of patients with advanced medullary thyroid cancer (MTC). However, treatment response heterogeneity leads to challenges in predicting individual favoura…
View article: Repeated Cranial and Large‐Vessel Positron Emission Tomography/Computed Tomography Scans and the Association With Structural Aortic Disease in Giant Cell Arteritis: A Five‐Year Observational Study
Repeated Cranial and Large‐Vessel Positron Emission Tomography/Computed Tomography Scans and the Association With Structural Aortic Disease in Giant Cell Arteritis: A Five‐Year Observational Study Open
Objective Giant cell arteritis (GCA) is characterized by cranial ischemia at diagnosis and late aortic structural disease. Repeated combined cranial and large‐vessel fluoro‐2‐deoxyglucose (FDG) positron emission tomography (PET)/computed t…
View article: The role of amino acid PET in radiotherapy target volume delineation for adult-type diffuse gliomas: A review of the literature
The role of amino acid PET in radiotherapy target volume delineation for adult-type diffuse gliomas: A review of the literature Open
AA-PET is a promising complementary tool to MRI for radiotherapy target volume delineation, with potential benefits requiring further validation including margin reduction and facilitation of dose-escalation.
View article: NIMG-41. MULTI-SITE, PROSPECTIVE TRIAL EVALUATING FET-PET IN GLIOBLASTOMA (FIG) STUDY (TROG 18.06): PRELIMINARY RESULTS OF CENTRAL NUCLEAR MEDICINE REVIEW OF FET-PET BIOLOGIC TARGET VOLUME DELINEATION FOR RADIATION PLANNING
NIMG-41. MULTI-SITE, PROSPECTIVE TRIAL EVALUATING FET-PET IN GLIOBLASTOMA (FIG) STUDY (TROG 18.06): PRELIMINARY RESULTS OF CENTRAL NUCLEAR MEDICINE REVIEW OF FET-PET BIOLOGIC TARGET VOLUME DELINEATION FOR RADIATION PLANNING Open
BACKGROUND To provide an update from the multi-site trial evaluating O-(2-[18F]-fluoroethyl)-L-tyrosine Positron Emission Tomography (FET-PET) in Glioblastoma (FIG) study and 2) assess the impact of central Nuclear Medicine physician (NMP)…
View article: P14.22.B THE ROLE OF AMINO ACID PET IN RADIOTHERAPY TARGET VOLUME DELINEATION FOR ADULT-TYPE DIFFUSE GLIOMAS: A SYSTEMATIC LITERATURE REVIEW
P14.22.B THE ROLE OF AMINO ACID PET IN RADIOTHERAPY TARGET VOLUME DELINEATION FOR ADULT-TYPE DIFFUSE GLIOMAS: A SYSTEMATIC LITERATURE REVIEW Open
BACKGROUND Amino acid positron-emission tomography (AA-PET) is an emerging tool to complement magnetic resonance imaging (MRI) in glioma management. This purpose of this review was to summarise the existing literature examining use of earl…
View article: Reducing noise in radioactive iodine activity selection: the utility of an online clinical calculator
Reducing noise in radioactive iodine activity selection: the utility of an online clinical calculator Open
Background: Noise, an unwanted variability in judgement, is ubiquitous in medicine, including in the prescription of radioactive iodine (RAI). Building upon our recently developed predictive risk model, we created an online clinical suppor…
View article: [<sup>18</sup>F]FDG PET/CT–Avid Discordant Volume as a Biomarker in Patients with Gastroenteropancreatic Neuroendocrine Neoplasms: A Multicenter Study
[<sup>18</sup>F]FDG PET/CT–Avid Discordant Volume as a Biomarker in Patients with Gastroenteropancreatic Neuroendocrine Neoplasms: A Multicenter Study Open
[18F]FDG PET/CT and [68Ga]Ga-DOTATATE PET/CT are both used to predict tumor biology in neuroendocrine neoplasms. Although the presence of discordant ([18F]FDG-avid/non-[68Ga]Ga-DOTATATE-avid) disease predicts poor prognosis, the significan…
View article: Development of a novel clinical support tool for active surveillance of low risk papillary thyroid cancer
Development of a novel clinical support tool for active surveillance of low risk papillary thyroid cancer Open
Background Active surveillance (AS) is an alternative to surgery in select patients with very low risk papillary thyroid cancer (PTC). Many clinicians feel ill-equipped in selecting appropriate patients. We aimed to 1) Develop an evidence-…
View article: <sup>64</sup>Cu Treatment Planning and<sup>67</sup>Cu Therapy with Radiolabeled [<sup>64</sup>Cu/<sup>67</sup>Cu]MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial Results for Human Imaging, Safety, Biodistribution, and Radiation Dosimetry
<sup>64</sup>Cu Treatment Planning and<sup>67</sup>Cu Therapy with Radiolabeled [<sup>64</sup>Cu/<sup>67</sup>Cu]MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial Results for Human Imaging, Safety, Biodistribution, and Radiation Dosimetry Open
Our aim was to report the use of 64Cu and 67Cu as a theranostic pair of radionuclides in human subjects. An additional aim was to measure whole-organ dosimetry of 64Cu and 67Cu attached to the somatostatin analog octreotate using the sarco…
View article: Dual [68Ga]DOTATATE and [18F]FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms: a multicentre validation of the NETPET score
Dual [68Ga]DOTATATE and [18F]FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms: a multicentre validation of the NETPET score Open
Background Gastroenteropancreatic neuroendocrine neoplasms (GEPNENs) are heterogeneous in clinical course, biology, and outcomes. The NETPET score predicts survival by scoring uptake on dual [ 68 Ga]DOTATATE and [ 18 F]FDG PET/CT scans. We…
View article: RF11 | PSAT370 I-PET Score: Combining Whole Body Iodine Scan and 18 Fluorodeoxyglucose Positron Emission Topography to Predict Progression in Thyroid Cancer
RF11 | PSAT370 I-PET Score: Combining Whole Body Iodine Scan and 18 Fluorodeoxyglucose Positron Emission Topography to Predict Progression in Thyroid Cancer Open
Introduction A well-known 'flip flop' phenomenon exists between whole-body scans (WBS) and 18FFDG PET imaging in differentiated thyroid cancer (DTC) such that cancer progression is typically associated with reduced iodine uptake and increa…
View article: I‐PET score: Combining whole body iodine and <sup>18</sup>F‐FDG PET/CT imaging to predict progression in structurally or biochemically incomplete thyroid cancer
I‐PET score: Combining whole body iodine and <sup>18</sup>F‐FDG PET/CT imaging to predict progression in structurally or biochemically incomplete thyroid cancer Open
Objective We propose a new scoring system (I‐PET) combining whole body scan (WBS) and FDG findings to identify patients who have or are likely to become refractory to radioactive iodine. Design Retrospective analysis of 142 patients age >1…
View article: 18F-FET PET in the diagnosis and prognostication of primary brain tumours
18F-FET PET in the diagnosis and prognostication of primary brain tumours Open
Poster: 2021 ASM / R-0072 / 18F-FET PET in the diagnosis and prognostication of primary brain tumours by: J. Gajera , H. Ireland, J. Drummond, E. Hsiao, G. Schembri, M. Back; Sydney, NSW/AU
View article: Change in Practice of Radioactive Iodine Administration in Differentiated Thyroid Cancer: A Single-Centre Experience
Change in Practice of Radioactive Iodine Administration in Differentiated Thyroid Cancer: A Single-Centre Experience Open
Objective: Our study aimed to analyse temporal trends in radioactive iodine (RAI) treatment for thyroid cancer over the past decade; to analyse key factors associated with clinical decisions in RAI dosing; and to confirm lower activities o…
View article: Supplementary Material for: Change in Practice of Radioactive Iodine Administration in Differentiated Thyroid Cancer: A Single-Centre Experience
Supplementary Material for: Change in Practice of Radioactive Iodine Administration in Differentiated Thyroid Cancer: A Single-Centre Experience Open
Objective: Our study aimed to analyse temporal trends in radioactive iodine (RAI) treatment for thyroid cancer over the past decade; to analyse key factors associated with clinical decisions in RAI dosing; and to confirm lower activities o…
View article: Evaluation of Fluorodeoxyglucose Positron Emission Tomography Scanning in the Neoadjuvant Therapy Paradigm in Pancreatic Ductal Adenocarcinoma
Evaluation of Fluorodeoxyglucose Positron Emission Tomography Scanning in the Neoadjuvant Therapy Paradigm in Pancreatic Ductal Adenocarcinoma Open
Objectives Little data exist on the utility of fluorodeoxyglucose positron emission tomography (FDG-PET) in operable pancreatic ductal adenocarcinoma (PDAC) treated with neoadjuvant (NA) therapy. Methods Consecutively treated patients with…
View article: Supplementary Material for: High Metabolic Tumour Volume on 18-Fluorodeoxyglucose Positron Emission Tomography Predicts Poor Survival from Neuroendocrine Neoplasms
Supplementary Material for: High Metabolic Tumour Volume on 18-Fluorodeoxyglucose Positron Emission Tomography Predicts Poor Survival from Neuroendocrine Neoplasms Open
Introduction: 18-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) avidity in neuroendocrine neoplasms (NENs) has been associated with higher-grade disease. 18F-FDG avidity and high SUVmax have been demonstrated to predict po…
View article: The Liver INSPECTR Trial: Towards improved understanding of liver function following radiotherapy
The Liver INSPECTR Trial: Towards improved understanding of liver function following radiotherapy Open
Liver stereotactic ablative body radiotherapy (SABR) is an emerging treatment option for primary liver cancer and liver metastases. Liver SABR can provide high rates of local control however tumour doses are limited by dose to surrounding …
View article: Pattern of care and survival of pancreatic ductal adenocarcinoma in a multi-disciplinary high-volume centre
Pattern of care and survival of pancreatic ductal adenocarcinoma in a multi-disciplinary high-volume centre Open
Introduction:Pancreas cancer remains a deadly disease.High volume specialist centres offer the potential of optimising patient outcomes and minimising the disparities in treatment delivered and survival outcomes. Methods:A retrospective co…
View article: Maxillary artery 18F‐<scp>FDG</scp> uptake as a new finding on <scp>PET</scp>/<scp>CT</scp> scan in a cohort of 41 patients suspected of having giant cell arteritis
Maxillary artery 18F‐<span>FDG</span> uptake as a new finding on <span>PET</span>/<span>CT</span> scan in a cohort of 41 patients suspected of having giant cell arteritis Open
Dear Editor, Giant cell arteritis (GCA) is a medium to large vessel vasculitis which commonly involves branches of the external carotid artery (ECA). It has been hypothesized that maxillary arteritis with associated demand ischemia to the …
View article: Utilizing 18F‐fluoroethyl‐<scp>l</scp>‐tyrosine positron emission tomography in high grade glioma for radiation treatment planning in patients with contraindications to <scp>MRI</scp>
Utilizing 18F‐fluoroethyl‐<span>l</span>‐tyrosine positron emission tomography in high grade glioma for radiation treatment planning in patients with contraindications to <span>MRI</span> Open
Introduction Patients with high grade glioma ( HGG ) and contraindications to magnetic resonance imaging ( MRI ) are dependent on contrast‐enhanced computerized tomography ( CT ) scan imaging for radiation therapy ( RT ) target volume deli…
View article: P17.02 Assessing the role of aggressive surgical RESECTION for IDH mutated Anaplastic Glioma: reflections from tumour volume reduction and patterns of relapse following PET guided IMRT with sequential temozolomide
P17.02 Assessing the role of aggressive surgical RESECTION for IDH mutated Anaplastic Glioma: reflections from tumour volume reduction and patterns of relapse following PET guided IMRT with sequential temozolomide Open
AIM: In patients with Anaplastic Glioma (AG) and IDH mutation(IDHmut) assess reduction in tumour volume and patterns of failure following intensity modulated radiation therapy(IMRT) and sequential temozolomide (TMZ). METHODS: Patients mana…
View article: Dual Somatostatin Receptor/FDG PET/CT Imaging in Metastatic Neuroendocrine Tumours: Proposal for a Novel Grading Scheme with Prognostic Significance
Dual Somatostatin Receptor/FDG PET/CT Imaging in Metastatic Neuroendocrine Tumours: Proposal for a Novel Grading Scheme with Prognostic Significance Open
Background: PET scans using FDG and somatostatin receptor imaging agents have both been used to study neuroendocrine tumours. Most reports have documented the sensitivity and specificity of each radiopharmaceutical independently, and even …
View article: Diagnosis of upper limb lymphedema: development of an evidence-based approach
Diagnosis of upper limb lymphedema: development of an evidence-based approach Open
For the first time, evidence-based clinical diagnostic thresholds have been established for secondary LE. With mild LE, normatively determined circumference and BIS thresholds are superior to the commonly used thresholds.
View article: Dual 18F-fluorodeoxyglucose/68Gallium DOTATATE (FDG/DOTA) PET grading and histological grade in neuroendocrine tumours (NET)
Dual 18F-fluorodeoxyglucose/68Gallium DOTATATE (FDG/DOTA) PET grading and histological grade in neuroendocrine tumours (NET) Open
Dual 18F-fluorodeoxyglucose/68Gallium DOTATATE (FDG/DOTA) PET grading and histological grade in neuroendocrine tumours (NET)