Geoffrey W. Coombs
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View article: Molecular mechanisms of resistance and tolerance of Staphylococcus aureus to daptomycin
Molecular mechanisms of resistance and tolerance of Staphylococcus aureus to daptomycin Open
Daptomycin is a cyclic lipopeptide antimicrobial used against gram-positive pathogens, including Staphylococcus aureus. Daptomycin relies on physiological calcium to anchor onto bacterial membranes and sequester lipid II, overproducing rea…
View article: Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Surveillance Outcome Program (GnSOP) Bloodstream Infection Annual Report 2024
Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Surveillance Outcome Program (GnSOP) Bloodstream Infection Annual Report 2024 Open
The Australian Group on Antimicrobial Resistance (AGAR) performs regular period-prevalence studies to monitor changes in antimicrobial resistance in selected enteric gram-negative pathogens. From 1 January 2024 to 31 December 2024, fifty-f…
View article: Australian Group on Antimicrobial Resistance (AGAR) Australian Enterococcal Surveillance Outcome Program (AESOP) Bloodstream Infection Annual Report 2024
Australian Group on Antimicrobial Resistance (AGAR) Australian Enterococcal Surveillance Outcome Program (AESOP) Bloodstream Infection Annual Report 2024 Open
From 1 January to 31 December 2024, fifty-five institutions across Australia participated in the Australian Enterococcal Surveillance Outcome Program (AESOP). The aim of AESOP 2024 was to determine the proportion of enterococcal bacteraemi…
View article: Australian Group on Antimicrobial Resistance (AGAR) surveillance outcome programs – bloodstream infections and antimicrobial resistance patterns in Australian children and adolescents, January 2022 – December 2023
Australian Group on Antimicrobial Resistance (AGAR) surveillance outcome programs – bloodstream infections and antimicrobial resistance patterns in Australian children and adolescents, January 2022 – December 2023 Open
Between January 2022 and December 2023, there were 1,827 bloodstream infection (BSI) isolates in 1,745 children and adolescents reported to the Australian Group on Antimicrobial Resistance (AGAR) surveillance outcome programs, with 40% of …
View article: Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP) Bloodstream Infection Annual Report 2024
Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP) Bloodstream Infection Annual Report 2024 Open
From 1 January to 31 December 2024, fifty-five institutions across Australia participated in the Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP). The aim of ASSOP 2024 was to determine the proportion of Staphylococcus…
View article: Microevolution associated with clonal expansion of a hypervirulent, penicillin-resistant lineage of Neisseria meningitidis in Western Australia
Microevolution associated with clonal expansion of a hypervirulent, penicillin-resistant lineage of Neisseria meningitidis in Western Australia Open
Neisseria meningitidis is a colonizer of the human nasopharynx which occasionally causes invasive meningococcal disease. Despite numerous reports of penicillin-resistant isolates, antimicrobial-resistant meningococcal clones have historica…
View article: Dual β-lactam synergy in <i>Enterococcus faecalis</i> and its relationship with penicillin-ceftriaxone infective endocarditis treatment outcomes
Dual β-lactam synergy in <i>Enterococcus faecalis</i> and its relationship with penicillin-ceftriaxone infective endocarditis treatment outcomes Open
Objectives Benzylpenicillin with ceftriaxone is used for outpatient antimicrobial therapy of Enterococcus faecalis infective endocarditis (EFIE) due to poor stability of aminopenicillins. The aim was to correlate the impact of benzylpenici…
View article: Mortality and length of stay associated with antimicrobial-susceptible and -resistant hospital-onset bloodstream infections at a tertiary referral hospital in Melbourne, Australia
Mortality and length of stay associated with antimicrobial-susceptible and -resistant hospital-onset bloodstream infections at a tertiary referral hospital in Melbourne, Australia Open
Background and objectives There are few Australian data regarding the burden of hospital-onset bloodstream infections (HO-BSIs). To quantify the impact of antimicrobial-susceptible and -resistant HO-BSIs on patient outcomes by augmenting l…
View article: Accurate identification of Enterococcus lactis causing bacteraemia by matrix-assisted laser desorption ionization-time of flight mass spectrometry
Accurate identification of Enterococcus lactis causing bacteraemia by matrix-assisted laser desorption ionization-time of flight mass spectrometry Open
Introduction. Enterococcus faecium clade B has recently been re-classified as Enterococcus lactis . Although E. lactis was previously associated with food products and probiotics, the recent re-classification has prompted the need for the …
View article: Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Surveillance Outcome Program (GnSOP) Bloodstream Infection Annual Report 2023
Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Surveillance Outcome Program (GnSOP) Bloodstream Infection Annual Report 2023 Open
The Australian Group on Antimicrobial Resistance (AGAR) performs regular period-prevalence studies to monitor changes in antimicrobial resistance in selected enteric gram-negative pathogens. From 1 January 2023 to 31 December 2023, a total…
View article: P-812. Not Little Adults: Key Differences in Antimicrobial Resistance in Australian Bloodstream Isolates between Children and Adults, 2020-2021
P-812. Not Little Adults: Key Differences in Antimicrobial Resistance in Australian Bloodstream Isolates between Children and Adults, 2020-2021 Open
Background The incidence, risks and organisms causing bloodstream infections (BSI) differ between children and adults due to distinct comorbidities, procedures and antibiotic exposures. Age-specific data are required to inform targeted int…
View article: Genomic Epidemiology of Clonal Complex 1 <i>Staphylococcus aureu</i> s in Remote Western Australian Communities
Genomic Epidemiology of Clonal Complex 1 <i>Staphylococcus aureu</i> s in Remote Western Australian Communities Open
Community‐associated methicillin‐resistant Staphylococcus aureus (CA‐MRSA) was first reported in Western Australia (WA) in the 1990s. Although ST8‐IVa [2B] (WA‐5) was the first identified CA‐MRSA in WA, ST1‐IVa [2B] (WA‐1) soon emerged as …
View article: Australian Group on Antimicrobial Resistance (AGAR) Australian Enterococcal Surveillance Outcome Program (AESOP) Bloodstream Infection Annual Report 2023
Australian Group on Antimicrobial Resistance (AGAR) Australian Enterococcal Surveillance Outcome Program (AESOP) Bloodstream Infection Annual Report 2023 Open
From 1 January to 31 December 2023, fifty-six institutions across Australia participated in the Australian Enterococcal Surveillance Outcome Program (AESOP). The aim of AESOP 2023 was to determine the proportion of enterococcal bacteraemia…
View article: Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP) Bloodstream Infection Annual Report 2023
Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP) Bloodstream Infection Annual Report 2023 Open
From 1 January to 31 December 2023, fifty-seven institutions across Australia participated in the Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP). The aim of ASSOP 2023 was to determine the proportion of Staphylococcu…
View article: Australian Group on Antimicrobial Research surveillance outcome programs – bloodstream infections and antimicrobial resistance patterns from patients less than 18 years of age, January 2020 – December 2021
Australian Group on Antimicrobial Research surveillance outcome programs – bloodstream infections and antimicrobial resistance patterns from patients less than 18 years of age, January 2020 – December 2021 Open
From 1 January 2020 to 31 December 2021, thirty-eight institutions across Australia submitted data to the Australian Group on Antimicrobial Resistance (AGAR) from patients aged < 18 years (AGAR-Kids). Over the two years, 1,679 isolates wer…
View article: Leveraging existing data to improve antimicrobial resistance-related mortality estimates for Australia
Leveraging existing data to improve antimicrobial resistance-related mortality estimates for Australia Open
Antimicrobial resistance (AMR) is a global pandemic, however, estimating its burden is a complex process. As a result, many countries rely on global estimates to infer burden within their own setting. With a growing number of recent public…
View article: Antimicrobial resistance among clinically significant bacteria in wildlife: An overlooked one health concern
Antimicrobial resistance among clinically significant bacteria in wildlife: An overlooked one health concern Open
Antimicrobial resistance (AMR) has emerged as a critical global health challenge. However, the significance of AMR is not limited to humans and domestic animals but extends to wildlife and the environment. Based on the analysis of > 200 pe…
View article: The Australian Group on Antimicrobial Resistance
The Australian Group on Antimicrobial Resistance Open
Antimicrobials are an integral component of healthcare delivery. When resistance to an antimicrobial emerges, it has a significant impact on an individual’s treatment and the community more broadly. In Australia, to monitor antimicrobial r…
View article: Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM
Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM Open
Standardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The …
View article: Emergence and clonal expansion of a qacA-harbouring sequence type 45 lineage of methicillin-resistant Staphylococcus aureus
Emergence and clonal expansion of a qacA-harbouring sequence type 45 lineage of methicillin-resistant Staphylococcus aureus Open
The past decade has seen an increase in the prevalence of sequence type (ST) 45 methicillin-resistant Staphylococcus aureus (MRSA), yet the underlying drivers for its emergence and spread remain unclear. To better understand the worldwide …
View article: Whole-genome sequencing identifies MprF mutations in a genetically diverse population of daptomycin non-susceptible Staphylococcus aureus in Australia
Whole-genome sequencing identifies MprF mutations in a genetically diverse population of daptomycin non-susceptible Staphylococcus aureus in Australia Open
Daptomycin non-susceptible S. aureus causing infections in Australia are polyclonal and harbour MprF mutation(s). The identification of multidrug-resistant daptomycin non-susceptible S. aureus is a public health concern.
View article: Non- <i>faecium</i> non- <i>faecalis</i> enterococci: a review of clinical manifestations, virulence factors, and antimicrobial resistance
Non- <i>faecium</i> non- <i>faecalis</i> enterococci: a review of clinical manifestations, virulence factors, and antimicrobial resistance Open
SUMMARY Enterococci are a diverse group of Gram-positive bacteria that are typically found as commensals in humans, animals, and the environment. Occasionally, they may cause clinically relevant diseases such as endocarditis, septicemia, u…
View article: Corrigendum: Genomic characterisation of a unique Panton-Valentine leucocidin-positive community-associated methicillin-resistant Staphylococcus aureus lineage increasingly impacting Australian indigenous communities
Corrigendum: Genomic characterisation of a unique Panton-Valentine leucocidin-positive community-associated methicillin-resistant Staphylococcus aureus lineage increasingly impacting Australian indigenous communities Open
Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our princi…
View article: Community-associated methicillin-resistant <i>Staphylococcus aureus</i> in the Kimberley region of Western Australia, epidemiology and burden on hospitals
Community-associated methicillin-resistant <i>Staphylococcus aureus</i> in the Kimberley region of Western Australia, epidemiology and burden on hospitals Open
This study presents surveillance data from 1 July 2003 to 30 June 2023 for community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) notified in the Kimberley region of Western Australia (WA) and describes the region’s cha…
View article: Genomic characterization of a unique Panton–Valentine leucocidin-positive community-associated methicillin-resistant Staphylococcus aureus lineage increasingly impacting on Australian indigenous communities
Genomic characterization of a unique Panton–Valentine leucocidin-positive community-associated methicillin-resistant Staphylococcus aureus lineage increasingly impacting on Australian indigenous communities Open
In 2010 a single isolate of a trimethoprim-resistant multilocus sequence type 5, Panton–Valentine leucocidin-positive, community-associated methicillin-resistant Staphylococcus aureus (PVL-positive ST5 CA-MRSA), colloquially named WA121, w…
View article: 2780. Factors associated with <i>Staphylococcus aureus</i> susceptibility to two lytic bacteriophages; Comparison of phage host susceptibility using a reference set of <i>S. aureus</i>
2780. Factors associated with <i>Staphylococcus aureus</i> susceptibility to two lytic bacteriophages; Comparison of phage host susceptibility using a reference set of <i>S. aureus</i> Open
Background Timely access is a major concern when considering phage therapy. Using susceptible phage is critical for the outcomes of phage therapy. For timely access to susceptible phages, identifying factors associated with phage susceptib…
View article: Australian Group on Antimicrobial Resistance (AGAR) Australian Enterococcal Surveillance Outcome Program (AESOP) - Bloodstream Infection Annual Report 2022
Australian Group on Antimicrobial Resistance (AGAR) Australian Enterococcal Surveillance Outcome Program (AESOP) - Bloodstream Infection Annual Report 2022 Open
From 1 January to 31 December 2022, fifty-five institutions across Australia participated in the Australian Enterococcal Surveillance Outcome Program (AESOP). The aim of AESOP 2022 was to determine the proportion of enterococcal bacteraemi…
View article: Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Surveillance Outcome - Program (ASSOP) Bloodstream Infection Annual Report 2022
Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Surveillance Outcome - Program (ASSOP) Bloodstream Infection Annual Report 2022 Open
From 1 January to 31 December 2022, fifty-five institutions across Australia participated in the Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP). The aim of ASSOP 2022 was to determine the proportion of Staphylococcus…
View article: Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Surveillance Outcome Program (GnSOP) - Bloodstream Infection Annual Report 2022
Australian Group on Antimicrobial Resistance (AGAR) Australian Gram-negative Surveillance Outcome Program (GnSOP) - Bloodstream Infection Annual Report 2022 Open
The Australian Group on Antimicrobial Resistance (AGAR) performs regular period-prevalence studies to monitor changes in antimicrobial resistance in selected enteric gram-negative pathogens. The 2022 survey was the tenth year to focus on b…