Geoffray Monteuuis
YOU?
Author Swipe
View article: Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer Open
View article: De novo serine biosynthesis is protective in mitochondrial disease
De novo serine biosynthesis is protective in mitochondrial disease Open
The importance of serine as a metabolic regulator is well known for tumors and is also gaining attention in degenerative diseases. Recent data indicate that de novo serine biosynthesis is an integral component of the metabolic response to …
View article: Neopterin extends C. elegans lifespan in an ATFS-1-dependent manner
Neopterin extends C. elegans lifespan in an ATFS-1-dependent manner Open
Neopterin, a byproduct of tetrahydrobiopterin synthesis, is commonly used as a biomarker for immune system activation. In addition to its role in immune responses, neopterin levels are known to increase with age. Its impact on longevity, h…
View article: COA5 has an essential role in the early stage of mitochondrial complex IV assembly
COA5 has an essential role in the early stage of mitochondrial complex IV assembly Open
Pathogenic variants in cytochrome c oxidase assembly factor 5 (COA5), a proposed complex IV (CIV) assembly factor, have been shown to cause clinical mitochondrial disease with two siblings affected by neonatal hypertrophic cardiomyopathy m…
View article: COA5 has an essential role in the early stage of mitochondrial complex IV assembly
COA5 has an essential role in the early stage of mitochondrial complex IV assembly Open
Pathogenic variants in cytochrome c oxidase assembly factor 5 (COA5), a proposed complex IV (CIV) assembly factor, have been shown to cause clinical mitochondrial disease with two siblings affected by neonatal hypertrophic cardiomyopathy m…
View article: Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation Open
Mitochondrial ribosomes (mitoribosomes) have undergone substantial evolutionary structural remodeling accompanied by loss of ribosomal RNA, while acquiring unique protein subunits located on the periphery. We generated CRISPR-mediated knoc…
View article: Data from Holding on to Junk Bonds: Intron Retention in Cancer and Therapy
Data from Holding on to Junk Bonds: Intron Retention in Cancer and Therapy Open
Intron retention (IR) in cancer was for a long time overlooked by the scientific community, as it was previously considered to be an artifact of a dysfunctional spliceosome. Technological advancements made in the last decade offer unique o…
View article: Supplementary Figure S1 from Holding on to Junk Bonds: Intron Retention in Cancer and Therapy
Supplementary Figure S1 from Holding on to Junk Bonds: Intron Retention in Cancer and Therapy Open
IR in CAR-T cell treatment and a possible approach to therapy. Development of antisense oligonucleotides-based therapies to correct pathological IR events.
View article: Supplementary Figure S1 from Holding on to Junk Bonds: Intron Retention in Cancer and Therapy
Supplementary Figure S1 from Holding on to Junk Bonds: Intron Retention in Cancer and Therapy Open
IR in CAR-T cell treatment and a possible approach to therapy. Development of antisense oligonucleotides-based therapies to correct pathological IR events.
View article: Data from Holding on to Junk Bonds: Intron Retention in Cancer and Therapy
Data from Holding on to Junk Bonds: Intron Retention in Cancer and Therapy Open
Intron retention (IR) in cancer was for a long time overlooked by the scientific community, as it was previously considered to be an artifact of a dysfunctional spliceosome. Technological advancements made in the last decade offer unique o…
View article: <i>De novo</i>serine biosynthesis is protective in mitochondrial disease
<i>De novo</i>serine biosynthesis is protective in mitochondrial disease Open
Importance of serine as a metabolic regulator is well known in tumors and raising attention also in degenerative diseases. Recent data indicate that de novo serine biosynthesis is an integral component of metabolic response to mitochondria…
View article: Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation Open
Summary Mitochondrial ribosomes (mitoribosomes) have undergone substantial structural remodelling throughout evolution. Compared to their prokaryotic counterparts, mitoribosomes show a substantial loss of ribosomal RNA, whilst acquiring un…
View article: The Fusion of CLEC12A and MIR223HG Arises from a trans-Splicing Event in Normal and Transformed Human Cells
The Fusion of CLEC12A and MIR223HG Arises from a trans-Splicing Event in Normal and Transformed Human Cells Open
Chimeric RNAs are often associated with chromosomal rearrangements in cancer. In addition, they are also widely detected in normal tissues, contributing to transcriptomic complexity. Despite their prevalence, little is known about the char…
View article: A hunt for <i>OM45</i> synthetic petite interactions in <i>Saccharomyces cerevisiae</i> reveals a role for Miro GTPase Gem1p in cristae structure maintenance
A hunt for <i>OM45</i> synthetic petite interactions in <i>Saccharomyces cerevisiae</i> reveals a role for Miro GTPase Gem1p in cristae structure maintenance Open
Om45 is a major protein of the yeast's outer mitochondrial membrane under respiratory conditions. However, the cellular role of the protein has remained obscure. Previously, deletion mutant phenotypes have not been found, and clear amino a…
View article: In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration
In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration Open
View article: In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration
In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration Open
We investigated the clinical, genetic, and pathological characteristics of a previously unknown severe juvenile brain disorder in several litters of Parson Russel Terriers. The disease started with epileptic seizures at 6 to 12 weeks of ag…
View article: Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients
Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients Open
Vast transcriptomics and epigenomics changes are characteristic of human cancers, including leukaemia. At remission, we assume that these changes normalise so that omics-profiles resemble those of healthy individuals. However, an in-depth …
View article: Holding on to Junk Bonds: Intron Retention in Cancer and Therapy
Holding on to Junk Bonds: Intron Retention in Cancer and Therapy Open
Intron retention (IR) in cancer was for a long time overlooked by the scientific community, as it was previously considered to be an artifact of a dysfunctional spliceosome. Technological advancements made in the last decade offer unique o…
View article: Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukemia patients
Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukemia patients Open
Background Vast transcriptomics and epigenomics changes are characteristic of human cancers including leukemia. At remission, we assume that these changes normalise so that omics-profiles resemble those of healthy individuals. However, an …
View article: Computational Methods for Intron Retention Identification and Quantification
Computational Methods for Intron Retention Identification and Quantification Open
Alternative splicing is a ubiquitous process that increases transcriptomic and proteomic complexity across the animal kingdom. Intron retention (IR) is a particular form of alternative splicing that is different from the other forms as it …
View article: The changing paradigm of intron retention: regulation, ramifications and recipes
The changing paradigm of intron retention: regulation, ramifications and recipes Open
Intron retention (IR) is a form of alternative splicing that has long been neglected in mammalian systems although it has been studied for decades in non-mammalian species such as plants, fungi, insects and viruses. It was generally assume…
View article: Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins
Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins Open
Utilization of non-AUG alternative translation start sites is most common in bacteria and viruses, but it has been also reported in other organisms. This phenomenon increases proteome complexity by allowing expression of multiple protein i…
View article: Non-AUG translation generates new protein isoforms with mitochondrial localization
Non-AUG translation generates new protein isoforms with mitochondrial localization Open