Geoffrey R. Hill
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View article: Multiplex detection of gastrointestinal microbiota using short probes in graft vs. host disease
Multiplex detection of gastrointestinal microbiota using short probes in graft vs. host disease Open
Background: Association of bacterial taxa to graft vs. host disease (GVHD) have relied on examination of fecal samples, but tissue and cellular localization remains largely unexplored due to technical challenges. We augment a spatial trans…
View article: Effect of fecal microbiota transplantation on gut microbiota functional profile in recipients of allogeneic hematopoietic cell transplantation
Effect of fecal microbiota transplantation on gut microbiota functional profile in recipients of allogeneic hematopoietic cell transplantation Open
Intestinal dysbiosis has been associated with both the effectiveness and toxicity of immunotherapy in cancer patients, inspiring multiple trials investigating fecal microbiota transplantation (FMT) in these patients. FMT restores microbial…
View article: Defining pathogenic IL-17 and CSF-1 gene expression signatures in chronic graft-versus-host disease
Defining pathogenic IL-17 and CSF-1 gene expression signatures in chronic graft-versus-host disease Open
Chronic graft-versus-host disease (cGVHD) remains the leading cause of nonrelapse morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Effective therapeutic agents targeting dysregulated cytokines including in…
View article: Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect
Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect Open
View article: Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT
Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT Open
The current approach to minimize transplant-associated complications, including graft-versus-host disease (GVHD) includes long-term pharmacological immune suppression frequently accompanied by unwanted side effects. Advances in targeted im…
View article: The Psychological Effects of Guillain-Barré Syndrome: A Grounded Theory Study
The Psychological Effects of Guillain-Barré Syndrome: A Grounded Theory Study Open
Guillain–Barré syndrome is a rare neurological condition. Research has increased our understanding of the etiology, prognosis, and effective medical treatment of the illness. There is a lack of understanding regarding the psychological eff…
View article: Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD. Reply.
Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD. Reply. Open
View article: Single-cell analysis of the multiple myeloma microenvironment after γ-secretase inhibition and CAR T-cell therapy
Single-cell analysis of the multiple myeloma microenvironment after γ-secretase inhibition and CAR T-cell therapy Open
Chimeric antigen receptor (CAR) T cells and bispecific antibodies targeting B-cell maturation antigen (BCMA) have significantly advanced the treatment of relapsed and refractory multiple myeloma. Resistance to BCMA-targeting therapies, non…
View article: CMV reactivation during pretransplantation evaluation: a novel risk factor for posttransplantation CMV reactivation
CMV reactivation during pretransplantation evaluation: a novel risk factor for posttransplantation CMV reactivation Open
Cytomegalovirus (CMV) disease occurs occasionally before allogeneic hematopoietic cell transplantation (HCT) and is associated with poor post-HCT outcomes; however, the impact of pre-HCT CMV reactivation is unknown. Pre-HCT CMV reactivatio…
View article: Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD
Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD Open
Calcineurin inhibitors (CNIs) constitute the backbone of modern acute graft-versus-host disease (aGVHD) prophylaxis regimens but have limited efficacy in the prevention and treatment of chronic GVHD (cGVHD). We investigated the effect of C…
View article: TIM-3 <sup>+</sup> CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies
TIM-3 <sup>+</sup> CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies Open
Chronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here, we identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an apparent terminally exhausted phenotype (T PHEX ), expressed gra…
View article: IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation
IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation Open
Endothelial function and integrity are compromised after allogeneic bone marrow transplantation (BMT), but how this affects immune responses broadly remains unknown. Using a preclinical model of CMV reactivation after BMT, we found comprom…
View article: Mycophenolate mofetil is associated with inferior overall survival in cytomegalovirus seropositive patients with acute myeloid leukemia undergoing hematopoietic cell transplantation
Mycophenolate mofetil is associated with inferior overall survival in cytomegalovirus seropositive patients with acute myeloid leukemia undergoing hematopoietic cell transplantation Open
Not available.
View article: Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation Open
View article: Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation
Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation Open
Autologous stem cell transplantation (ASCT) is the standard of care consolidation therapy for eligible patients with myeloma but most patients eventually progress, an event associated with features of immune escape. Novel approaches to enh…
View article: Autophagy prevents graft failure during murine graft-versus-host disease
Autophagy prevents graft failure during murine graft-versus-host disease Open
Autophagy is an intracellular survival process that has established roles in the long-term survival and function of hematopoietic stem cells (HSC). We investigated the contribution of autophagy to HSC fitness during allogeneic transplantat…
View article: HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant
HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant Open
Limited understanding of the immunopathogenesis of human herpesvirus 6B (HHV-6B) has prevented its acceptance as a pulmonary pathogen after hematopoietic cell transplant (HCT). In this prospective multicenter study of patients undergoing b…
View article: Human herpesvirus 6B (HHV-6B) detection and genome-wide host expression profiles implicate HHV-6B as a pulmonary pathogen after hematopoietic cell transplantation
Human herpesvirus 6B (HHV-6B) detection and genome-wide host expression profiles implicate HHV-6B as a pulmonary pathogen after hematopoietic cell transplantation Open
Limited understanding of the immunopathogenesis of human herpesvirus 6B (HHV-6B) has prevented its acceptance as a pulmonary pathogen after hematopoietic cell transplantation (HCT). We conducted a prospective multicenter study of patients …
View article: Revisiting the Utility of Granulocyte Colony-Stimulating Factor Post-Autologous Hematopoietic Stem Cell Transplantation for Outpatient-Based Transplantations
Revisiting the Utility of Granulocyte Colony-Stimulating Factor Post-Autologous Hematopoietic Stem Cell Transplantation for Outpatient-Based Transplantations Open
View article: Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity Open
View article: Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection
Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infection Open
View article: [Data S10] Microbiota dictate T cell clonal selection to promote graft-vs-host disease after stem cell transplantation
[Data S10] Microbiota dictate T cell clonal selection to promote graft-vs-host disease after stem cell transplantation Open
Data S10. 10x genomics sequencing data files for Figure 5. Matrix file "sample_filtered_feature_bc_matrix.h5" and V(D)J annotations "filtered_contig_annotations.csv" are included below. Accompanying code can be found at https://github.com/…
View article: [Data S10] Microbiota dictate T cell clonal selection to promote graft-vs-host disease after stem cell transplantation
[Data S10] Microbiota dictate T cell clonal selection to promote graft-vs-host disease after stem cell transplantation Open
Data S10. 10x genomics sequencing data files for Figure 5. Matrix file "sample_filtered_feature_bc_matrix.h5" and V(D)J annotations "filtered_contig_annotations.csv" are included below. Accompanying code can be found at https://github.com/…
View article: [Github Sample Dataset] Microbiota dictate T cell clonal selection to promote graft-vs-host disease after stem cell transplantation
[Github Sample Dataset] Microbiota dictate T cell clonal selection to promote graft-vs-host disease after stem cell transplantation Open
[Github Sample Dataset]. This is an accompanying data set for the github repository "https://github.com/acyeh-lab/2023/tree/main/tcr-simulation" referred to in "Non-genetic determinants of clonotypic T cell expansion following ste…
View article: [Data S2] Microbiota dictate T cell clonal selection to augment graft-vs-host disease after stem cell transplantation
[Data S2] Microbiota dictate T cell clonal selection to augment graft-vs-host disease after stem cell transplantation Open
Data S2. GLIPH2 hits for all recipient pairs amongst B6 to B6D2F1 transplants with or without antibiotic exposure and 900cGy vs. 1300cGy TBI conditioning. For all TCRs within each recipient pair (12 mice total, 66 pairs for spleen; 15 pair…
View article: [Data S1] Microbiota dictate T cell clonal selection to augment graft-vs-host disease after stem cell transplantation
[Data S1] Microbiota dictate T cell clonal selection to augment graft-vs-host disease after stem cell transplantation Open
Data S1. ALICE hits for all recipient pairs amongst B6 to B6D2F1 transplants with or without antibiotic exposure and 900cGy vs. 1300cGy TBI conditioning. For each recipient pair (12 mice total, 66 pairs for spleen; 15 pairs for SILP analys…
View article: [Data S1] Microbiota dictate T cell clonal selection to augment graft-vs-host disease after stem cell transplantation
[Data S1] Microbiota dictate T cell clonal selection to augment graft-vs-host disease after stem cell transplantation Open
Data S1. ALICE hits for all recipient pairs amongst B6 to B6D2F1 transplants with or without antibiotic exposure and 900cGy vs. 1300cGy TBI conditioning. For each recipient pair (12 mice total, 66 pairs for spleen; 15 pairs for SILP analys…
View article: [Data S2] Microbiota dictate T cell clonal selection to augment graft-vs-host disease after stem cell transplantation
[Data S2] Microbiota dictate T cell clonal selection to augment graft-vs-host disease after stem cell transplantation Open
Data S2. GLIPH2 hits for all recipient pairs amongst B6 to B6D2F1 transplants with or without antibiotic exposure and 900cGy vs. 1300cGy TBI conditioning. For all TCRs within each recipient pair (12 mice total, 66 pairs for spleen; 15 pair…
View article: [Github Sample Dataset] Microbiota dictate T cell clonal selection to promote graft-vs-host disease after stem cell transplantation
[Github Sample Dataset] Microbiota dictate T cell clonal selection to promote graft-vs-host disease after stem cell transplantation Open
[Github Sample Dataset]. This is an accompanying data set for the github repository "https://github.com/acyeh-lab/2023/tree/main/tcr-simulation" referred to in "Non-genetic determinants of clonotypic T cell expansion following ste…
View article: Type-1 regulatory T cells are critical for curative immunotherapy outcomes
Type-1 regulatory T cells are critical for curative immunotherapy outcomes Open
IL-10 producing CD4+ type-1 regulatory T cells (Tr1) mediate immune tolerance during chronic infection, autoimmunity, and transplantation. We previously demonstrated that eomesodermin (Eomes) promotes Tr1 cell (Eomes+IL-10+) development af…