Geon Ha Kim
YOU?
Author Swipe
View article: Bridging the barrier: insights into blood biomarkers and therapeutic strategies targeting choroid plexus and BBB dysfunction in alzheimer’s disease
Bridging the barrier: insights into blood biomarkers and therapeutic strategies targeting choroid plexus and BBB dysfunction in alzheimer’s disease Open
Alzheimer’s disease (AD) is the most common cause of dementia and accounts for approximately 60–80% of total dementia patients. Currently, accurate diagnosis for AD relies on cerebrospinal fluid (CSF) sampling or a positron emission tomogr…
View article: Unveiling blood biomarkers for neuronal hyperplasticity: Insights from AD molecular subtyping, a comprehensive review
Unveiling blood biomarkers for neuronal hyperplasticity: Insights from AD molecular subtyping, a comprehensive review Open
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, predominantly affecting the aging population. Early detection through biomarkers is essential for early intervention. Recent sub‐classification of AD through extens…
View article: Standardized Procedures for Blood and Cerebrospinal Fluid Collection and Storage in Neurodegenerative Biomarker Research: A Comprehensive Review.
Standardized Procedures for Blood and Cerebrospinal Fluid Collection and Storage in Neurodegenerative Biomarker Research: A Comprehensive Review. Open
Blood and cerebrospinal fluid (CSF) biomarkers are essential tools for the rapid diagnosis and monitoring of neurodegenerative diseases like Alzheimer's disease (AD). However, even minor variations in sample collection and storage procedur…
View article: Validation of criteria for frontotemporal dementia with right anterior temporal lobe predominance
Validation of criteria for frontotemporal dementia with right anterior temporal lobe predominance Open
INTRODUCTION Frontotemporal dementia (FTD) with right anterior temporal lobe (rATL) predominance lacks universally agreed‐upon diagnostic criteria. This study validated the Amsterdam diagnostic tree (ADT) for right temporal variant FTD (rt…
View article: Machine learning based prediction of cognitive metrics using major biomarkers in SuperAgers
Machine learning based prediction of cognitive metrics using major biomarkers in SuperAgers Open
As populations age, understanding cognitive decline and age-related diseases like dementia has become increasingly important. "SuperAgers," individuals over 65 with cognitive abilities similar to those in their 40s, provide a unique perspe…
View article: Substitute or Supplement? The Role of Multimodal Digital Biomarkers in Mobile Cognitive Impairment Assessment Tools
Substitute or Supplement? The Role of Multimodal Digital Biomarkers in Mobile Cognitive Impairment Assessment Tools Open
Digital biomarkers (DBMs) have emerged as promising tools for the detection of cognitive impairment (CI). While many studies have examined their diagnostic value individually, few studies have examined how they fare in multimodal settings.…
View article: Can Software Robot Enhance Cognitive Functions of Senior People?: An Longitudinal Exploratory Field Study with Korean Older Adults (Preprint)
Can Software Robot Enhance Cognitive Functions of Senior People?: An Longitudinal Exploratory Field Study with Korean Older Adults (Preprint) Open
BACKGROUND The global prevalence of dementia is increasing at a substantial rate, underscoring the urgent need for effective treatment tools. As cognitive interventions become more accessible, non-pharmacological treatments such as digita…
View article: Rapid yet reliable: Optimising mobile cognitive assessment tool for older adults
Rapid yet reliable: Optimising mobile cognitive assessment tool for older adults Open
Growing dementia prevalence underscores the need for efficient screening methods, but lengthy digital assessments often cause fatigue among older adults. To address this, we developed and validated the Digital Assessment of Cognitive Impai…
View article: Physical Activity, Alzheimer Plasma Biomarkers, and Cognition
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition Open
Importance Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored. Objective To investigate the associations among …
View article: South Korean study to prevent cognitive impairment and protect brain health through multidomain interventions via face‐to‐face and video communication platforms in mild cognitive impairment (SUPERBRAIN‐MEET): A randomized controlled trial
South Korean study to prevent cognitive impairment and protect brain health through multidomain interventions via face‐to‐face and video communication platforms in mild cognitive impairment (SUPERBRAIN‐MEET): A randomized controlled trial Open
INTRODUCTION We investigated the efficacy of a multidomain intervention (MI) via face‐to‐face and video communication platforms using a tablet personal computer application in patients with mild cognitive impairment (MCI). METHODS Three hu…
View article: Clinical Practice Guidelines for Dementia: Recommendations for Cholinesterase Inhibitors and Memantine
Clinical Practice Guidelines for Dementia: Recommendations for Cholinesterase Inhibitors and Memantine Open
This guideline offers standardized, evidence-based pharmacologic recommendations for dementia management, with specific guidance on cholinesterase inhibitors and NMDA receptor antagonists. It aims to support clinical decision-making and im…
View article: Clinical Practice Guidelines for Dementia: Recommendations for the Pharmacological Treatment of Behavioral and Psychological Symptoms
Clinical Practice Guidelines for Dementia: Recommendations for the Pharmacological Treatment of Behavioral and Psychological Symptoms Open
These guidelines provide a structured approach to pharmacological management of BPSD in dementia, addressing efficacy and safety profiles across drug categories. The recommendations emphasize personalized treatment plans to optimize therap…
View article: Eligibility for Lecanemab Treatment in the Republic of Korea: Real-World Data From Memory Clinics
Eligibility for Lecanemab Treatment in the Republic of Korea: Real-World Data From Memory Clinics Open
Eligibility for lecanemab treatment was not restricted to Korean patients with early AD except for those with an MMSE score of ≥22. The MMSE criteria should therefore be reconsidered in areas with a higher proportion of older people, who t…
View article: Executive Summary of 2025 International Conference of the Korean Dementia Association and International Congress of the Asian Society Against Dementia (IC-KDA/ASAD 2025): A Report From the Academic Committee of the Korean Dementia Association
Executive Summary of 2025 International Conference of the Korean Dementia Association and International Congress of the Asian Society Against Dementia (IC-KDA/ASAD 2025): A Report From the Academic Committee of the Korean Dementia Association Open
The International Conference of the Korean Dementia Association (IC-KDA) 2025 was held jointly with the 19th International Congress of the Asian Society Against Dementia (ASAD) in Seoul, South Korea (May 8-10, 2025), under the theme "Break…
View article: Effects of a 12-Week Hybrid Analog–Digital Cognitive Training on Cognitively Unimpaired Older Adults: A Pilot Single-Blind Randomized Controlled Trial
Effects of a 12-Week Hybrid Analog–Digital Cognitive Training on Cognitively Unimpaired Older Adults: A Pilot Single-Blind Randomized Controlled Trial Open
Clinical Research Information Service Identifier: KCT0007922.
View article: Investigating the Validity of Digital Biomarkers in the Preclinical Screening of Cognitive Normal, Amyloid‐β‐ MCI and Amyloid‐β+ MCI
Investigating the Validity of Digital Biomarkers in the Preclinical Screening of Cognitive Normal, Amyloid‐β‐ MCI and Amyloid‐β+ MCI Open
Background Amyloid‐β is widely known as a substantial biomarker in the diagnosis of Alzheimer’s disease. However, detection of amyloid‐β through neuroimaging techniques requires huge amounts of resources. There is a growing demand to detec…
View article: Gait Speed as a Marker of Superior Physical Performance in SuperAgers: Cognitive and Neuroanatomical Correlates
Gait Speed as a Marker of Superior Physical Performance in SuperAgers: Cognitive and Neuroanatomical Correlates Open
Background Cognitive abilities, notably memory, typically decline with age, but a subset of individuals known as superagers defy this trend by exhibiting memory functions akin to those 20‐30 years younger in late life. Recognizing the inte…
View article: Subthreshold amyloid deposition, cerebral small vessel disease, and functional brain network disruption in delayed cognitive decline after stroke
Subthreshold amyloid deposition, cerebral small vessel disease, and functional brain network disruption in delayed cognitive decline after stroke Open
Background Although its incidence is relatively low, delayed-onset post-stroke cognitive decline (PSCD) may offer valuable insights into the “vascular contributions to cognitive impairment and dementia,” particularly concerning the roles o…
View article: Predicting superagers: a machine learning approach utilizing gut microbiome features
Predicting superagers: a machine learning approach utilizing gut microbiome features Open
Objective Cognitive decline is often considered an inevitable aspect of aging; however, recent research has identified a subset of older adults known as “superagers” who maintain cognitive abilities comparable to those of younger individua…
View article: Elevated cerebral blood flow proxy with increased beta-amyloid burden in Alzheimer’s disease preclinical phase evaluated by dual-phase 18F-florbetaben positron emission tomography
Elevated cerebral blood flow proxy with increased beta-amyloid burden in Alzheimer’s disease preclinical phase evaluated by dual-phase 18F-florbetaben positron emission tomography Open
This study investigated the earliest change of cerebral blood flow (CBF) and its relationship with β-amyloid (Aβ) burden in preclinical Alzheimer's disease (AD) employing dual-phase 18F-florbetaben (FBB) PET. Seventy-one cognitively normal…
View article: Primary Sjögren’s Syndrome Presenting with Dyskinesia
Primary Sjögren’s Syndrome Presenting with Dyskinesia Open
Sjögren’s syndrome (SS) is an autoimmune disease in which lymphocytes invade salivary and tear glands, leading to dry mouth and dry eyes. It is also associated with extraglandular manifestations. The most frequently reported neurological e…
View article: Alterations in Gut Microbiota and Their Correlation with Brain Beta-Amyloid Burden Measured by 18F-Florbetaben PET in Mild Cognitive Impairment Due to Alzheimer’s Disease
Alterations in Gut Microbiota and Their Correlation with Brain Beta-Amyloid Burden Measured by 18F-Florbetaben PET in Mild Cognitive Impairment Due to Alzheimer’s Disease Open
(1) Background: This study investigated changes in the gut microbial composition of individuals with mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) and their relationship with positron emission tomography (PET) amyloid acc…
View article: Geriatric depression and anxiety screening via deep learning using activity tracking and sleep data
Geriatric depression and anxiety screening via deep learning using activity tracking and sleep data Open
Background Geriatric depression and anxiety have been identified as mood disorders commonly associated with the onset of dementia. Currently, the diagnosis of geriatric depression and anxiety relies on self‐reported assessments for primary…
View article: Executive Summary of 2023 International Conference of the Korean Dementia Association (IC-KDA 2023): A Report From the Academic Committee of the Korean Dementia Association
Executive Summary of 2023 International Conference of the Korean Dementia Association (IC-KDA 2023): A Report From the Academic Committee of the Korean Dementia Association Open
The Korean Dementia Association (KDA) has been organizing biennial international academic conferences since 2019, with the International Conference of the KDA (IC-KDA) 2023 held in Busan under the theme 'Beyond Boundaries: Advancing Global…
View article: Lecanemab: Appropriate Use Recommendations by Korean Dementia Association
Lecanemab: Appropriate Use Recommendations by Korean Dementia Association Open
Lecanemab (product name Leqembi®) is an anti-amyloid monoclonal antibody treatment approved for use in Korea for patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's disease. The Korean Dementia Association has…
View article: The Usefulness of <sup>18</sup>F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis
The Usefulness of <sup>18</sup>F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis Open
18F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, …