Georg J. Arnold
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View article: Supplementary Figures from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer
Supplementary Figures from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer Open
Suppl. Figure 1. (A) Immunostaining for ADNP and β-Catenin on serial sections of two colon cancers. (B) Staining intensities of ADNP in colon cancer cells (n = 500, 5 different tumors) with high or low nuclear β- Catenin expression. …
View article: Supplementary Tables, Materials and Methods from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer
Supplementary Tables, Materials and Methods from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer Open
Supplementary Tables 1-7 Supplementary Materials and Methods Suppl. Table 1. WNT target gene sets used for GSEA Suppl. Table 2. Gene Expression (real-time RT-PCR) primers used in this study. Primers were selected from the Universal Probe L…
View article: Supplementary Figures from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer
Supplementary Figures from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer Open
Suppl. Figure 1. (A) Immunostaining for ADNP and β-Catenin on serial sections of two colon cancers. (B) Staining intensities of ADNP in colon cancer cells (n = 500, 5 different tumors) with high or low nuclear β- Catenin expression. …
View article: Supplementary Tables, Materials and Methods from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer
Supplementary Tables, Materials and Methods from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer Open
Supplementary Tables 1-7 Supplementary Materials and Methods Suppl. Table 1. WNT target gene sets used for GSEA Suppl. Table 2. Gene Expression (real-time RT-PCR) primers used in this study. Primers were selected from the Universal Probe L…
View article: Data from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer
Data from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer Open
Purpose: Constitutively active WNT signaling is a hallmark of colorectal cancers and a driver of malignant tumor progression. Therapeutic targeting of WNT signaling is difficult due to high pathway complexity and its role in tissue homeost…
View article: Data from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer
Data from ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer Open
Purpose: Constitutively active WNT signaling is a hallmark of colorectal cancers and a driver of malignant tumor progression. Therapeutic targeting of WNT signaling is difficult due to high pathway complexity and its role in tissue homeost…
View article: Differential Effects of Insulin-Deficient Diabetes Mellitus on Visceral vs. Subcutaneous Adipose Tissue—Multi-omics Insights From the Munich MIDY Pig Model
Differential Effects of Insulin-Deficient Diabetes Mellitus on Visceral vs. Subcutaneous Adipose Tissue—Multi-omics Insights From the Munich MIDY Pig Model Open
Adipose tissue (AT) is no longer considered to be responsible for energy storage only but is now recognized as a major endocrine organ that is distributed across different parts of the body and is actively involved in regulatory processes …
View article: A scalable, clinically severe pig model for Duchenne muscular dystrophy
A scalable, clinically severe pig model for Duchenne muscular dystrophy Open
Large-animal models for Duchenne muscular dystrophy (DMD) are crucial for the evaluation of diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 (DMDΔ52) exhibit molecular, clinical and pathologic…
View article: A scalable, clinically severe pig model for Duchenne muscular dystrophy
A scalable, clinically severe pig model for Duchenne muscular dystrophy Open
Large animal models for Duchenne muscular dystrophy (DMD) are crucial for preclinical evaluation of novel diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 ( DMD Δ52) resemble molecular, clinic…
View article: Age-Related Alterations in the Testicular Proteome of a Non-Human Primate
Age-Related Alterations in the Testicular Proteome of a Non-Human Primate Open
Aging of human testis and associated cellular changes is difficult to assess. Therefore, we used a translational, non-human primate model to get insights into underlying cellular and biochemical processes. Using proteomics and immunohistoc…
View article: Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies
Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies Open
Background Many genetically multi‐modified donor lines for xenotransplantation have a background of domestic pigs with rapid body and organ growth. The intrinsic growth potential of porcine xeno‐organs may impair their long‐term function a…
View article: Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model
Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model Open
Age-related changes in the human testis may include morphological alterations, disturbed steroidogenesis, and impaired spermatogenesis. However, the specific impact of cell age remains poorly understood and difficult to assess. Testicular …
View article: The impact of transcription inhibition during in vitro maturation on the proteome of bovine oocytes†
The impact of transcription inhibition during in vitro maturation on the proteome of bovine oocytes† Open
Proper oocyte maturation is a prerequisite for successful reproduction and requires the resumption of meiosis to the metaphase II stage (MII). In bovine oocytes, nuclear maturation has been shown to occur in in vitro maturing cumulus-enclo…
View article: Metabolic implication of tigecycline as an efficacious second‐line treatment for sorafenib‐resistant hepatocellular carcinoma
Metabolic implication of tigecycline as an efficacious second‐line treatment for sorafenib‐resistant hepatocellular carcinoma Open
Sorafenib represents the current standard of care for patients with advanced‐stage hepatocellular carcinoma (HCC). However, acquired drug resistance occurs frequently during therapy and is accompanied by rapid tumor regrowth after sorafeni…
View article: Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model
Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model Open
Our integrated proteomics/targeted metabolomics study of GHR-deficient and control liver samples from a clinically relevant large animal model identified a spectrum of biological pathways that are significantly altered in the absence of GH…
View article: Trafficking of siRNA precursors by the dsRBD protein Blanks in Drosophila
Trafficking of siRNA precursors by the dsRBD protein Blanks in Drosophila Open
RNA interference targets aberrant transcripts with cognate small interfering RNAs, which derive from double-stranded RNA precursors. Several functional screens have identified Drosophila blanks/lump (CG10630) as a facilitator of RNAi, yet …
View article: A decade of experience with genetically tailored pig models for diabetes and metabolic research
A decade of experience with genetically tailored pig models for diabetes and metabolic research Open
The global prevalence of diabetes mellitus and other metabolic diseases is rapidly increasing. Animal models play pivotal roles in unravelling disease mechanisms and developing and testing therapeutic strategies. Rodents are the most widel…
View article: Downregulation of GRK5 hampers the migration of breast cancer cells
Downregulation of GRK5 hampers the migration of breast cancer cells Open
Sunitinib is a multispecific kinase inhibitor and one of its targets is the kinase GRK5, which is regulating a multitude of G protein-coupled receptors (GPCRs). In this study we demonstrate that a decreased GRK5 expression induced by knock…
View article: Proteomics of bovine endometrium, oocytes and early embryos
Proteomics of bovine endometrium, oocytes and early embryos Open
Summary. Embryo-maternal communication, as well as recognition and establishment of pregnancy, is predominantly controlled by secretion of hormones and proteins. Furthermore, uterine fluid serves as a histotroph and contains factors essent…
View article: Uterine fluid proteome changes during diapause and resumption of embryo development in roe deer (Capreolus capreolus)
Uterine fluid proteome changes during diapause and resumption of embryo development in roe deer (Capreolus capreolus) Open
The uterine microenvironment during pre-implantation presents a pro-survival milieu and is essential for embryo elongation in ruminants. The European roe deer ( Careolus capreolus ) pre-implantation embryo development is characterised by a…
View article: Necroptosis in primate luteolysis: a role for ceramide
Necroptosis in primate luteolysis: a role for ceramide Open
The corpus luteum (CL) is a transient endocrine organ, yet molecular mechanisms resulting in its demise are not well known. The presence of phosphorylated mixed lineage kinase domain-like pseudokinase pMLKL(T357/S358) in human and nonhuman…
View article: Inhibition of Cyclin‐Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy
Inhibition of Cyclin‐Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy Open
Therapeutic options for patients with advanced‐stage hepatocellular carcinoma (HCC) are very limited. The only approved first‐line treatment is the multi‐tyrosine kinase inhibitor sorafenib, which shows low response rates and severe side e…
View article: A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF‑7 breast cancer cells
A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF‑7 breast cancer cells Open
Breast cancer exhibits the highest incidence of all cancer types and is the 2nd leading cause of cancer mortality in women. Up to 82% of breast cancer patients receive a chemotherapy‑containing treatment regimen. However, numerous breast t…
View article: Insights into the role of androgen receptor in human testicular peritubular cells
Insights into the role of androgen receptor in human testicular peritubular cells Open
Summary Contractile smooth muscle‐like peritubular cells build the wall of seminiferous tubules in men. They are crucial for sperm transport and complement the functions of Sertoli cells by secreting factors, including glial cell line‐deri…
View article: Characterization of a non-human primate model for the study of testicular peritubular cells—comparison with human testicular peritubular cells
Characterization of a non-human primate model for the study of testicular peritubular cells—comparison with human testicular peritubular cells Open
This work was supported by grants from the Deutsche Forschungsgemeinschaft (MA 1080/27-1; AR 362/9-1; BE 2296/8-1). The authors declare no competing financial interests.