Georg Berding
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View article: PET imaging of tissue reactions in the implanted cochlea: results of a pilot study
PET imaging of tissue reactions in the implanted cochlea: results of a pilot study Open
Purpose After cochlear implantation, molecular processes at the electrode–nerve interface significantly influence the variability in clinical outcomes. The present study investigates molecular processes in a guinea pig model of cochlear im…
View article: Associations between neuropsychological profile and regional brain FDG uptake in progressive supranuclear palsy
Associations between neuropsychological profile and regional brain FDG uptake in progressive supranuclear palsy Open
Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative movement disorder clinically characterized by falls, axial rigidity, vertical supranuclear gaze palsy, bradykinesia, and cognitive decline. There is a relative lac…
View article: Added value of FDG-PET for detection of progressive supranuclear palsy
Added value of FDG-PET for detection of progressive supranuclear palsy Open
Background Diagnostic criteria for progressive supranuclear palsy (PSP) include midbrain atrophy in MRI and hypometabolism in [ 18 F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) as supportive features. Due to limited data re…
View article: Age-related deficits in binaural hearing: Contribution of peripheral and central effects
Age-related deficits in binaural hearing: Contribution of peripheral and central effects Open
Pure-tone audiograms often poorly predict elderly humans’ ability to communicate in everyday complex acoustic scenes. Binaural processing is crucial for discriminating sound sources in such complex acoustic scenes. The compromised percepti…
View article: Automatic covariance pattern analysis outperforms visual reading of <sup>18</sup>F‐fluorodeoxyglucose‐positron emission tomography (<scp>FDG‐PET)</scp> in variant progressive supranuclear palsy
Automatic covariance pattern analysis outperforms visual reading of <sup>18</sup>F‐fluorodeoxyglucose‐positron emission tomography (<span>FDG‐PET)</span> in variant progressive supranuclear palsy Open
Background To date, studies on positron emission tomography (PET) with 18 F‐fluorodeoxyglucose (FDG) in progressive supranuclear palsy (PSP) usually included PSP cohorts overrepresenting patients with Richardson's syndrome (PSP‐RS). Object…
View article: Brain <scp>MRI</scp> in Progressive Supranuclear Palsy with Richardson's Syndrome and Variant Phenotypes
Brain <span>MRI</span> in Progressive Supranuclear Palsy with Richardson's Syndrome and Variant Phenotypes Open
Background Brain magnetic resonance imaging (MRI) is used to support the diagnosis of progressive supranuclear palsy (PSP). However, the value of visual descriptive, manual planimetric, automatic volumetric MRI markers and fully automatic …
View article: Bifrontal electroconvulsive therapy leads to improvement of cerebral glucose hypometabolism in frontotemporal dementia with comorbid psychotic depression – a case report
Bifrontal electroconvulsive therapy leads to improvement of cerebral glucose hypometabolism in frontotemporal dementia with comorbid psychotic depression – a case report Open
Background Differentiating depression and dementia in elderly patients represents a major clinical challenge for psychiatrists. Pharmacological and non-pharmacological treatment options for both conditions are often used cautiously due to …
View article: Case report: Early-onset Parkinson's disease with initial spastic paraparesis and hyperreflexia caused by compound heterozygous PRKN-gene exon 2 and 4 deletions
Case report: Early-onset Parkinson's disease with initial spastic paraparesis and hyperreflexia caused by compound heterozygous PRKN-gene exon 2 and 4 deletions Open
Pathogenic variants in the Parkin-gene ( PRKN ) are among the most common genetic causes of early onset Parkinson's disease (EOPD). Patients with EOPD can present with atypical clinical features and misdiagnosis is frequent. Here, we repor…
View article: An unusual presentation of Huntington’s disease
An unusual presentation of Huntington’s disease Open
We describe the case of a 59‐year‐old woman who exhibited psychotic symptoms, cognitive dysfunction, and restlessness. While the clinical picture and 18F‐FDG PET/CT suggested the presence of a tauopathy, especially frontotemporal dementia …
View article: Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation
Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation Open
Purpose Calcineurin inhibitors (CNI) can cause long-term impairment of brain function. Possible pathomechanisms include alterations of the cerebral immune system. This study used positron emission tomography (PET) imaging with the transloc…
View article: Combined Brain-Perfusion SPECT and EEG Measurements Suggest Distinct Strategies for Speech Comprehension in CI Users With Higher and Lower Performance
Combined Brain-Perfusion SPECT and EEG Measurements Suggest Distinct Strategies for Speech Comprehension in CI Users With Higher and Lower Performance Open
Cochlear implantation constitutes a successful therapy of inner ear deafness, with the majority of patients showing good outcomes. There is, however, still some unexplained variability in outcomes with a number of cochlear-implant (CI) use…
View article: Author Correction: Serotonin transporter binding is increased in Tourette syndrome with Obsessive Compulsive Disorder
Author Correction: Serotonin transporter binding is increased in Tourette syndrome with Obsessive Compulsive Disorder Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Reliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio
Reliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio Open
Purpose Tracer kinetic modeling of tissue time activity curves and the individual input function based on arterial blood sampling and metabolite correction is the gold standard for quantitative characterization of microglia activation by P…
View article: Severe Progressive Multifocal Leukoencephalopathy (PML) and Spontaneous Immune Reconstitution Inflammatory Syndrome (IRIS) in an Immunocompetent Patient
Severe Progressive Multifocal Leukoencephalopathy (PML) and Spontaneous Immune Reconstitution Inflammatory Syndrome (IRIS) in an Immunocompetent Patient Open
Background: Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection with JC-virus (JCV), a papova-virus, affecting mostly oligodendrocytes and the white matter of the central nervous system. Progressive Multifocal Le…
View article: Speech Processing in Cochlear-Implant Patients: Results of Corresponding EEG and Brain Perfusion-SPECT Measurements
Speech Processing in Cochlear-Implant Patients: Results of Corresponding EEG and Brain Perfusion-SPECT Measurements Open
The current study examines the underlying mechanisms of speech processing in CI patients using a multimodal approach. Data are collected by single photon emission tomography (SPECT) and electroencephalography (EEG).
View article: Serotonin transporter binding is increased in Tourette syndrome with Obsessive Compulsive Disorder
Serotonin transporter binding is increased in Tourette syndrome with Obsessive Compulsive Disorder Open
While the importance of the serotonergic system in obsessive compulsive disorder (OCD) is well established, its role in Tourette syndrome (TS) is uncertain. Particularly in TS patients with comorbid OCD (TS + OCD), decreased serotonin tran…
View article: Visualization of the auditory pathway in rats with 18F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation
Visualization of the auditory pathway in rats with 18F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation Open
Activation studies with positron emission tomography (PET) in auditory implant users explained some of the mechanisms underlying the variability of achieved speech comprehension. Since future developments of auditory implants will include …
View article: Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children
Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children Open
Our data indicate that it is feasible to detect auditory cortex activations in 15O-water PET during general anesthesia. Combined with the improved signal to noise ratios of modern PET scanners, this suggests reasonable prospects for furthe…
View article: Imaging in hearing using radiotracers
Imaging in hearing using radiotracers Open
Radiotracers offer unique options for brain imaging of functional and molecular processes related to hearing. Such imaging can be applied in a broad spectrum of situations from preclinical research to clinical patient care. Functional imag…
View article: Effect of Deep Brain Stimulation on Regional Cerebral Blood Flow in Patients with Medically Refractory Tourette Syndrome
Effect of Deep Brain Stimulation on Regional Cerebral Blood Flow in Patients with Medically Refractory Tourette Syndrome Open
In this study, alterations in brain perfusion have been investigated in patients with Tourette syndrome (TS) compared with control subjects. In addition, we investigated the effects of deep brain stimulation (DBS) in both globus pallidus i…
View article: Diagnostic accuracy of cadmium-zinc-telluride-based myocardial perfusion SPECT: impact of attenuation correction using a co-registered external computed tomography
Diagnostic accuracy of cadmium-zinc-telluride-based myocardial perfusion SPECT: impact of attenuation correction using a co-registered external computed tomography Open
Attenuation correction with a co-registered external CT is feasible using CZT cameras and improves diagnostic accuracy mostly by improving specificity over uncorrected images.
View article: Positron Emission Tomography Imaging Reveals Auditory and Frontal Cortical Regions Involved with Speech Perception and Loudness Adaptation
Positron Emission Tomography Imaging Reveals Auditory and Frontal Cortical Regions Involved with Speech Perception and Loudness Adaptation Open
Considerable progress has been made in the treatment of hearing loss with\nauditory implants. However, there are still many implanted patients that\nexperience hearing deficiencies, such as limited speech understanding or\nvanishing percep…
View article: CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls
CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls Open
CSF abnormalities have been reported in CSF leakage syndrome. However, the mechanism for these CSF changes is actually unknown and they may indicate impaired CSF flow or blood-CSF barrier. Angiopoietin-2 (Ang-2), a protein which is express…