Georg Goliasch
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View article: Implementation of Medical Therapy in Different Stages of Heart Failure with Reduced Ejection Fraction: An Analysis of the VIENNA-HF Registry
Implementation of Medical Therapy in Different Stages of Heart Failure with Reduced Ejection Fraction: An Analysis of the VIENNA-HF Registry Open
Background/Objectives: Real-world evidence shows alarmingly suboptimal utilization of guideline directed medical therapy (GDMT) in heart failure with reduced ejection fraction (HFrEF). One of the barriers of GDMT implementation appears to …
View article: Implementation of Medical Therapy in Different Stages of Heart Failure with Reduced Ejection Fraction: An Analysis of the VIENNA-HF Registry
Implementation of Medical Therapy in Different Stages of Heart Failure with Reduced Ejection Fraction: An Analysis of the VIENNA-HF Registry Open
Background/Objectives. Real-world evidence shows alarmingly suboptimal utilization of GDMT in HFrEF. One of the barriers of GDMT implementation appears to be concerns about the potential development of drug-related ad-verse events (AEs), p…
View article: Electrocardiographic alterations in patients treated for acute Lassa Fever: Description of results from a phase II clinical trial in Nigeria
Electrocardiographic alterations in patients treated for acute Lassa Fever: Description of results from a phase II clinical trial in Nigeria Open
ECG alterations observed in both treatment arms are compatible with direct cardiac effects of the LASV. The combination of new onset of chest pain combined with the evolution of ECG findings over time are suggestive for the occurrence of p…
View article: Implementation of medical therapy in different stages of heart failure with reduced ejection fraction
Implementation of medical therapy in different stages of heart failure with reduced ejection fraction Open
Background Real-world evidence shows alarmingly suboptimal utilization of GDMT in HFrEF. One of the barriers of GDMT implementation appears to be concerns about the potential development of drug-related adverse events (AEs), particularly i…
View article: Valvular Heart Diseases
Valvular Heart Diseases Open
View article: Impact of oncologic diseases on outcome in patients with severe isolated tricuspid regurgitation
Impact of oncologic diseases on outcome in patients with severe isolated tricuspid regurgitation Open
Background Severe tricuspid regurgitation (TR) is associated with high morbidity and mortality. Isolated TR, defined as TR without overt heart disease, is typical and offers limited cardiac treatment options other than interventional repai…
View article: Management of Fluid Overload in Patients With Severe Aortic Stenosis (EASE-TAVR)
Management of Fluid Overload in Patients With Severe Aortic Stenosis (EASE-TAVR) Open
In patients with severe AS and concomitant FO, quantitatively guided decongestive treatment and associated intensified management post-TAVR was associated with improved outcomes and quality of life compared to decongestion by clinical judg…
View article: Excess renin is attributed to the combination of forward and backward failure in HFrEF
Excess renin is attributed to the combination of forward and backward failure in HFrEF Open
Aims Regulation of the renin‐angiotensin system (RAS) in heart failure (HF) with reduced ejection fraction (HFrEF) still raises questions, as a large proportion of patients show normal renin levels despite manifest disease. Experimental ve…
View article: CILP-1 Is a Biomarker for Backward Failure and Right Ventricular Dysfunction in HFrEF
CILP-1 Is a Biomarker for Backward Failure and Right Ventricular Dysfunction in HFrEF Open
Background: CILP-1 regulates myocardial fibrotic response and remodeling and was reported to indicate right ventricular dysfunction (RVD) in pulmonary hypertension (PH) and heart failure (HF). This study examines CILP-1 as a potential biom…
View article: Iron status and the Pi/FGF-23-axis in HFrEF in relation to renal function
Iron status and the Pi/FGF-23-axis in HFrEF in relation to renal function Open
Background Recent studies linked dysregulated phosphate metabolism, fibroblast growth factor-23 (FGF-23) and iron deficiency (ID) with worse clinical outcome and mortality in heart failure with reduced ejection fraction (HFrEF). These fact…
View article: Contemporary insights into the epidemiology, impact and treatment of secondary tricuspid regurgitation across the heart failure spectrum
Contemporary insights into the epidemiology, impact and treatment of secondary tricuspid regurgitation across the heart failure spectrum Open
Background Tricuspid regurgitation secondary to heart failure (sTR) is common with considerable impact on survival and hospitalization rates. Currently, insights into epidemiology, impact, and treatment of sTR across the entire heart failu…
View article: Right ventricular global longitudinal strain on cardiovascular magnetic resonance imaging predicts outcome in patients undergoing transcatheter edge-to-edge mitral valve repair
Right ventricular global longitudinal strain on cardiovascular magnetic resonance imaging predicts outcome in patients undergoing transcatheter edge-to-edge mitral valve repair Open
Background Right ventricular dysfunction (RVD) on echocardiography was shown to predict outcomes in patients undergoing transcatheter edge-to-edge mitral valve repair (M-TEER). However, the prognostic value of left and RV global longitudin…
View article: Impact of right ventricular to pulmonary artery coupling on remodeling and outcome in patients undergoing transcatheter edge-to-edge mitral valve repair
Impact of right ventricular to pulmonary artery coupling on remodeling and outcome in patients undergoing transcatheter edge-to-edge mitral valve repair Open
Background Right ventricular to pulmonary artery (RV-PA) coupling has recently been shown to be associated with outcome in valvular heart disease. However, longitudinal data on RV dysfunction and reverse cardiac remodeling in patients foll…
View article: Quantitative fluid overload in severe aortic stenosis refines cardiac damage and associates with worse outcomes
Quantitative fluid overload in severe aortic stenosis refines cardiac damage and associates with worse outcomes Open
Background Cardiac decompensation in aortic stenosis (AS) involves extra-valvular cardiac damage (CD) and progressive fluid overload (FO). FO can be objectively quantified using bioimpedance spectroscopy (BIS). Objectives We aimed to asses…
View article: Impact of right ventricular-to-pulmonary artery coupling on remodeling and outcome in patients undergoing transcatheter edge-to-edge mitral valve repair
Impact of right ventricular-to-pulmonary artery coupling on remodeling and outcome in patients undergoing transcatheter edge-to-edge mitral valve repair Open
View article: Neurodegeneration is strongly linked to heart failure severity and outcomes: framing the cardiocerebral syndrome
Neurodegeneration is strongly linked to heart failure severity and outcomes: framing the cardiocerebral syndrome Open
Background and Objectives Cognitive impairment is prevalent in patients with heart failure with reduced ejection fraction (HFrEF), affecting self-care and outcomes. Novel blood-based biomarkers have emerged as potential diagnostic tools fo…
View article: Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry
Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry Open
Background and Aims Even though vegetation size in infective endocarditis (IE) has been associated with embolic events (EEs) and mortality risk, it is unclear whether vegetation size associated with these potential outcomes is different in…
View article: Identification of Gene Expression Signatures for Phenotype-Specific Drug Targeting of Cardiac Fibrosis
Identification of Gene Expression Signatures for Phenotype-Specific Drug Targeting of Cardiac Fibrosis Open
We have designed translational animal models to investigate cardiac profibrotic gene signatures. Domestic pigs were treated with cardiotoxic drugs (doxorubicin, DOX, n = 5 or Myocet®, MYO, n = 5) to induce replacement fibrosis via cardioto…
View article: Bleeding and thrombotic events in post-cardiotomy extracorporeal life support
Bleeding and thrombotic events in post-cardiotomy extracorporeal life support Open
OBJECTIVES Haemorrhagic and thrombotic complications are known obstacles in extracorporeal life support (ECLS), and patients requiring post-cardiotomy (PC)-ECLS are particularly prone. The objective of this study was to characterize the in…
View article: A streamlined, machine learning-derived approach to risk-stratification in heart failure patients with secondary tricuspid regurgitation
A streamlined, machine learning-derived approach to risk-stratification in heart failure patients with secondary tricuspid regurgitation Open
Aims Secondary tricuspid regurgitation (sTR) is the most frequent valvular heart disease and has a significant impact on mortality. A high burden of comorbidities often worsens the already dismal prognosis of sTR, while tricuspid intervent…
View article: Monitoring of mitral‐ and tricuspid valve interventions with <scp>CardioMEMS</scp>: Insights beyond imaging
Monitoring of mitral‐ and tricuspid valve interventions with <span>CardioMEMS</span>: Insights beyond imaging Open
Background Mitral‐ and tricuspid regurgitation are associated with significant morbidity and mortality and are increasingly treated interventionally. CardioMEMS is a transcutaneously implanted pressure sensor placed in the pulmonary artery…
View article: Issue Information
Issue Information Open
View article: Renin Trajectories and Outcome in Stable Heart Failure with Reduced Ejection Fraction (HFrEF) on Contemporary Therapy: A Monocentric Study from an Austrian Tertiary Hospital Outpatient Clinic
Renin Trajectories and Outcome in Stable Heart Failure with Reduced Ejection Fraction (HFrEF) on Contemporary Therapy: A Monocentric Study from an Austrian Tertiary Hospital Outpatient Clinic Open
Introduction. The renin-angiotensin system (RAS) is the main target of neurohumoral therapy in heart failure with reduced ejection fraction (HFrEF) effectively reducing mortality. Reasonably, renin might serve as a biomarker for risk predi…
View article: Infective endocarditis in adult patients with congenital heart disease
Infective endocarditis in adult patients with congenital heart disease Open
View article: Effects of guideline directed medical therapy on secondary mitral regurgitation
Effects of guideline directed medical therapy on secondary mitral regurgitation Open
Background Guideline directed medical therapy (GDMT) is the recommended initial treatment for secondary mitral regurgitation (SMR), however supported by only little comprehensive evidence. This study therefore sought to assess the effect o…
View article: Malnutrition in patients with chronic heart failure
Malnutrition in patients with chronic heart failure Open
Background Malnutrition is highly common in patients with chronic heart failure and often overlooked. It can accelerate disease progression by activating cytokines, causing autonomic dysfunction and cachexia. If malnutrition is detected ea…
View article: Neurofilaments in heart failure-depicting the brain-heart axis
Neurofilaments in heart failure-depicting the brain-heart axis Open
Introduction Experimental studies have fueled theoretical concerns about neurocognitive side effects of the angiotensin-receptor-neprilysin-inhibitor (ARNi) sacubitril/valsartan as neprilysin is not only involved in the degradation of vaso…
View article: A streamlined, machine learning-derived approach to risk-stratification in heart failure patients with secondary tricuspid regurgitation
A streamlined, machine learning-derived approach to risk-stratification in heart failure patients with secondary tricuspid regurgitation Open
Background Secondary tricuspid regurgitation (sTR) is the most frequent valvular heart disease and has significant impact on mortality. A high burden of comorbidities often worsens the already dismal prognosis of sTR, while tricuspid inter…
View article: Hepatic T1-Time Predicts Cardiovascular Risk in All-Comers Referred for Cardiovascular Magnetic Resonance: A Post-Hoc Analysis
Hepatic T1-Time Predicts Cardiovascular Risk in All-Comers Referred for Cardiovascular Magnetic Resonance: A Post-Hoc Analysis Open
Background: Liver damage is frequently observed in patients with cardiovascular disease but infrequently quantified. We hypothesized that in patients with cardiovascular disease undergoing cardiac magnetic resonance, liver T1-times indicat…
View article: Supervised learning-derived tailored risk-stratification in patients with severe secondary mitral regurgitation
Supervised learning-derived tailored risk-stratification in patients with severe secondary mitral regurgitation Open
Background Mitral regurgitation secondary to heart failure (sMR) has considerable impact on quality of life, heart failure (HF) rehospitalizations and mortality. A diverse burden of comorbidities suggests multifaceted aspects of individual…