Georg Mann
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View article: Hypersensitivity Reactions to Native E. coli L-asparaginase in Children With Acute Lymphoblastic Leukemia Treated in Trial ALL-BFM 2000: Impact of Treatment Schedule and Type of Glucocorticoid in Induction
Hypersensitivity Reactions to Native E. coli L-asparaginase in Children With Acute Lymphoblastic Leukemia Treated in Trial ALL-BFM 2000: Impact of Treatment Schedule and Type of Glucocorticoid in Induction Open
Asparaginase (ASNase) has become one of the key components in the treatment of acute lymphoblastic leukemia (ALL) by exploiting the inability of leukemic cells to synthesize the otherwise nonessential amino acid asparagine.1,2 Currently, 3…
View article: Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia
Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia Open
Although initial central nervous system (CNS) involvement is rarely detected in childhood acute lymphoblastic leukemia (ALL), risk-adapted CNS-directed therapy is essential for all patients. Treatment intensity depends on the initial CNS s…
View article: Data from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Data from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Purpose: Tumor relapse is the most frequent cause of death in stage 4 neuroblastomas. Since genomic information on the relapse precursor cells could guide targeted therapy, our aim was to find the most appropriate tissue for identifying re…
View article: Supplementary Table S1 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S1 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S1. Tumor cell content of samples of the single neuroblastoma patient
View article: Supplementary Table S5 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S5 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S5. Presence of 1q, 19q, and ATRX deletions in samples of patients with these aberrations
View article: Supplementary Table S7 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S7 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S7. Effect of low expression of some genes located at 1q or 19q on survival of neuroblastoma patients according to different datasets in R2 database
View article: Supplementary Table S7 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S7 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S7. Effect of low expression of some genes located at 1q or 19q on survival of neuroblastoma patients according to different datasets in R2 database
View article: Supplementary Table S2 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S2 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S2. Samples' information and clinical information of stage 4 neuroblastoma patients included in the cohort
View article: Supplementary Table S6 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S6 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S6. Genes in the SROs of 1q and 19 deletions
View article: Supplementary Table S4 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S4 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S4. Focal copy number aberrations detected in the relapse samples
View article: Supplementary Table S5 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S5 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S5. Presence of 1q, 19q, and ATRX deletions in samples of patients with these aberrations
View article: Supplementary Table S3 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S3 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S3. Chromosomal aberrations and corresponding breakpoints and their subclonal frequencies in various samples of the single neuroblastoma patient
View article: Supplementary Table S4 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S4 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S4. Focal copy number aberrations detected in the relapse samples
View article: Supplementary Figures S1-S8 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Figures S1-S8 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Fig. S1: Stepwise accumulation of segmental chromosomal aberrations (SCAs) in chromosome 7 of the case study. Supplementary Fig. S2: Whole genome views of 10 different samples of a single stage 4 neuroblastoma patient. Supple…
View article: Supplementary Figures S1-S8 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Figures S1-S8 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Fig. S1: Stepwise accumulation of segmental chromosomal aberrations (SCAs) in chromosome 7 of the case study. Supplementary Fig. S2: Whole genome views of 10 different samples of a single stage 4 neuroblastoma patient. Supple…
View article: Supplementary Table S2 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S2 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S2. Samples' information and clinical information of stage 4 neuroblastoma patients included in the cohort
View article: Supplementary Table S1 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S1 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S1. Tumor cell content of samples of the single neuroblastoma patient
View article: Supplementary Table S6 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S6 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S6. Genes in the SROs of 1q and 19 deletions
View article: Supplementary Table S3 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Supplementary Table S3 from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Supplementary Table S3. Chromosomal aberrations and corresponding breakpoints and their subclonal frequencies in various samples of the single neuroblastoma patient
View article: Data from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone
Data from Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone Open
Purpose: Tumor relapse is the most frequent cause of death in stage 4 neuroblastomas. Since genomic information on the relapse precursor cells could guide targeted therapy, our aim was to find the most appropriate tissue for identifying re…
View article: Response-adapted omission of radiotherapy in children and adolescents with early-stage classical Hodgkin lymphoma and an adequate response to vincristine, etoposide, prednisone, and doxorubicin (EuroNet-PHL-C1): a titration study
Response-adapted omission of radiotherapy in children and adolescents with early-stage classical Hodgkin lymphoma and an adequate response to vincristine, etoposide, prednisone, and doxorubicin (EuroNet-PHL-C1): a titration study Open
Deutsche Krebshilfe, Elternverein für Krebs-und leukämiekranke Kinder, Gießen, Kinderkrebsstiftung Mainz of the Journal Oldtimer Markt, Tour der Hoffnung, Menschen für Kinder, Mitteldeutsche Kinderkrebsforschung, Programme Hospitalier de R…
View article: Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/<i>KMT2A</i>Rearrangements in a Modern Therapy Era: A Retrospective International Study
Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/<i>KMT2A</i>Rearrangements in a Modern Therapy Era: A Retrospective International Study Open
PURPOSE We aimed to study prognostic factors and efficacy of allogeneic hematopoietic stem-cell transplantation (allo-HSCT) in first remission of patients with noninfant childhood acute lymphoblastic leukemia (ALL) with 11q23/ KMT2A rearra…
View article: Invasive Fungal Diseases Impact On Outcome of Childhood ALL – An Analysis of the International Trial AIEOP-BFM ALL 2009
Invasive Fungal Diseases Impact On Outcome of Childhood ALL – An Analysis of the International Trial AIEOP-BFM ALL 2009 Open
In children with acute lymphoblastic leukemia (ALL), risk groups for invasive fungal disease (IFD) with need for antifungal prophylaxis are not well characterized, and with the advent of new antifungal compounds, current data on outcome ar…
View article: Second malignant neoplasms after treatment of 1487 children and adolescents with acute lymphoblastic leukemia—A population‐based analysis of the Austrian ALL‐BFM Study Group
Second malignant neoplasms after treatment of 1487 children and adolescents with acute lymphoblastic leukemia—A population‐based analysis of the Austrian ALL‐BFM Study Group Open
Second malignant neoplasms (SMN) after primary childhood acute lymphoblastic leukemia (ALL) are rare. Among 1487 ALL patients diagnosed between 1981 and 2010 in Austria, the 10‐year cumulative incidence of an SMN was 1.1% ± 0.3%. There was…
View article: Allogeneic Hematopoietic Stem Cell Transplantation for Children With Acute Lymphoblastic Leukemia: Shifting Indications in the Era of Immunotherapy
Allogeneic Hematopoietic Stem Cell Transplantation for Children With Acute Lymphoblastic Leukemia: Shifting Indications in the Era of Immunotherapy Open
Pediatric acute lymphoblastic leukemia generally carries a good prognosis, and most children will be cured and become long-term survivors. However, a portion of children will harbor high-risk features at the time of diagnosis, have a poor …
View article: Other (Non-CNS/Testicular) Extramedullary Localizations of Childhood Relapsed Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma—A Report from the ALL-REZ Study Group
Other (Non-CNS/Testicular) Extramedullary Localizations of Childhood Relapsed Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma—A Report from the ALL-REZ Study Group Open
Children with other extramedullary relapse of acute lymphoblastic leukemia are currently poorly characterized. We aim to assess the prevalence and the clinical, therapeutic and prognostic features of extramedullary localizations other than…
View article: Copy Number Changes and Allele Distribution Patterns of Chromosome 21 in B Cell Precursor Acute Lymphoblastic Leukemia
Copy Number Changes and Allele Distribution Patterns of Chromosome 21 in B Cell Precursor Acute Lymphoblastic Leukemia Open
Chromosome 21 is the most affected chromosome in childhood acute lymphoblastic leukemia. Many of its numerical and structural abnormalities define diagnostically and clinically important subgroups. To obtain an overview about their types a…
View article: Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium
Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium Open
Comparison of treatment strategies in de novo pediatric acute lymphoblastic leukemia (ALL) requires standardized measures of efficacy. Key parameters that define disease-related events, including complete remission (CR), treatment failure …
View article: Diagnosis and management of acute appendicitis in 21 pediatric hematology and oncology patients at a tertiary care cancer center
Diagnosis and management of acute appendicitis in 21 pediatric hematology and oncology patients at a tertiary care cancer center Open
Acute appendicitis is a rare gastrointestinal complication of anti-cancer chemotherapy and hematopoietic stem cell transplantation. Among a cohort of 2341 hemato-oncologic patients at a pediatric tertiary care cancer center, we identified …