Georg Marckmann
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View article: Beneficence‐Based Obligations and Ethics Consultation in Assisted Dying
Beneficence‐Based Obligations and Ethics Consultation in Assisted Dying Open
In ethical debates on assisted dying, the principle of respect for autonomy is usually invoked to justify respecting requests for assisted dying. However, there are not only autonomy‐based obligations, but also obligations arising from the…
View article: Ethical Implications of Social Science Research on Xenotransplantation
Ethical Implications of Social Science Research on Xenotransplantation Open
Social science research has generated extensive knowledge on xenotransplantation, encompassing the perspectives of actual and potential patients, other stakeholders, public opinion and debate, human‐animal relationships, animal production …
View article: Assisted suicide in persons with mental disorders: a review of clinical-ethical arguments and recommendations
Assisted suicide in persons with mental disorders: a review of clinical-ethical arguments and recommendations Open
Persons with mental disorders have the same right to self-determination as patients with somatic diseases, also regarding death and dying. However, there are several challenges that render persons with mental disorders especially vulnerabl…
View article: Prioritization and Resource Allocation in the Context of the COVID-19 Pandemic: Recommendations for Colorectal and Pancreatic Cancer in Germany
Prioritization and Resource Allocation in the Context of the COVID-19 Pandemic: Recommendations for Colorectal and Pancreatic Cancer in Germany Open
In the context of the COVID-19 pandemic, there has been a scarcity of resources with various effects on the care of cancer patients. This paper provides an English summary of a German guideline on prioritization and resource allocation for…
View article: Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023
Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023 Open
This report comprises the contents of the presentations and following discussions of a workshop of the German Heart Transplant Centers in Martinsried, Germany on cardiac xenotransplantation. The production and current availability of genet…
View article: Parental perspectives about information and deferred versus two-stage consent in studies of neonatal asphyxia
Parental perspectives about information and deferred versus two-stage consent in studies of neonatal asphyxia Open
Objective The ALBINO Trial ( NCT03162653 ) investigates effects of very early postnatal allopurinol on neurocognitive outcome following perinatal asphyxia where prenatal informed consent (IC) is impossible. Ethically and legally, waiver of…
View article: Transformative medical ethics: A framework for changing practice according to normative–ethical requirements
Transformative medical ethics: A framework for changing practice according to normative–ethical requirements Open
We propose a step‐by‐step methodological framework of translational bioethics that aims at changing medical practice according to normative–ethical requirements, which we will thus call “transformative medical ethics.” The framework become…
View article: PP05.002 Retrospective evaluation of shared decision making in potentially life-threatening situations in the nursing home setting: a newly developed tool
PP05.002 Retrospective evaluation of shared decision making in potentially life-threatening situations in the nursing home setting: a newly developed tool Open
Background Nursing home (NH) residents are frequently subject of treatment decisions (TDs) in potentially life-threatening events (PLE). We developed a comprehensive tool to retrospectively evaluate the degree of SDM in PLE, and, in a pilo…
View article: BOS3c.004 Effectiveness of a complex advance care planning intervention focusing on nursing home residents: first results of the cluster-randomized controlled BEVOR-trial
BOS3c.004 Effectiveness of a complex advance care planning intervention focusing on nursing home residents: first results of the cluster-randomized controlled BEVOR-trial Open
Background Few trials on advance care planning (ACP) have investigated the clinical effect on care consistency with care preferences (3CP) in the nursing home (NH) setting. Methods BEVOR is a multi-centre, cluster-randomized controlled tri…
View article: BOS2c.002 What makes ACP effective? Necessary elements determined by a theory of change
BOS2c.002 What makes ACP effective? Necessary elements determined by a theory of change Open
Background International consensus definitions of Advance Care Planning (ACP) typically capture well the scope and purpose of ACP, and central characteristics of the ACP conversation. At an operational level, however, the elements of ACP t…
View article: PP18.002 Prevalence of advance care plans and care consistency with care preferences: a cluster-randomized controlled trial in 44 German nursing homes
PP18.002 Prevalence of advance care plans and care consistency with care preferences: a cluster-randomized controlled trial in 44 German nursing homes Open
Background The risk of life-threatening illness increases with frailty, and comorbidities, as indicated by rising rates of life-sustaining treatments. These, almost automatically applied, may evoke suffering, risk of traumatization of rela…
View article: Secondary data for global health digitalisation
Secondary data for global health digitalisation Open
Substantial opportunities for global health intelligence and research arise from the combined and optimised use of secondary data within data ecosystems. Secondary data are information being used for purposes other than those intended when…
View article: “We Absolutely Had the Impression That It Was Our Decision”—A Qualitative Study with Parents of Critically Ill Infants Who Participated in End-of-Life Decision Making
“We Absolutely Had the Impression That It Was Our Decision”—A Qualitative Study with Parents of Critically Ill Infants Who Participated in End-of-Life Decision Making Open
Background: Guidelines recommend shared decision making (SDM) between neonatologists and parents when a decision has to be made about the continuation of life-sustaining treatment (LST). In a previous study, we found that neonatologists an…
View article: Effectiveness of a complex regional advance care planning intervention to improve care consistency with care preferences: study protocol for a multi-center, cluster-randomized controlled trial focusing on nursing home residents (BEVOR trial)
Effectiveness of a complex regional advance care planning intervention to improve care consistency with care preferences: study protocol for a multi-center, cluster-randomized controlled trial focusing on nursing home residents (BEVOR trial) Open
Background According to recent legislation, facilitated advance care planning (ACP) for nursing home (NH) residents is covered by German sickness funds. However, the effects of ACP on patient-relevant outcomes have not been studied in Germ…
View article: Preparing n-of-1 Antisense Oligonucleotide Treatments for Rare Neurological Diseases in Europe: Genetic, Regulatory, and Ethical Perspectives
Preparing n-of-1 Antisense Oligonucleotide Treatments for Rare Neurological Diseases in Europe: Genetic, Regulatory, and Ethical Perspectives Open
Antisense oligonucleotide (ASO) therapies present a promising disease-modifying treatment approach for rare neurological diseases (RNDs). However, the current focus is on "more common" RNDs, leaving a large share of RND patients still with…
View article: Organ transplants of the future: planning for innovations including xenotransplantation
Organ transplants of the future: planning for innovations including xenotransplantation Open
The future clinical application of animal-to-human transplantation (xenotransplantation) is of importance to society as a whole. Favourable preclinical data relevant to cell, tissue and solid organ xenotransplants have been obtained from m…
View article: Advance care planning by proxy in German nursing homes: Descriptive analysis and policy implications
Advance care planning by proxy in German nursing homes: Descriptive analysis and policy implications Open
Background Legally recognized advance directives (ADs) have to be signed by the person to whom the decisions apply. In practice, however, there are also ADs written and signed by legal proxies (surrogates) on behalf of patients who lack de…
View article: Digital contact tracing and exposure notification: ethical guidance for trustworthy pandemic management
Digital contact tracing and exposure notification: ethical guidance for trustworthy pandemic management Open
There is growing interest in contact tracing apps (CT apps) for pandemic management. It is crucial to consider ethical requirements before, while, and after implementing such apps. In this paper, we illustrate the complexity and multiplici…
View article: Personalized medicine (PM)
Personalized medicine (PM) Open
PM seeks to improve stratification and timing of health care by utilizing biological information and biomarkers on the level of molecular disease pathways, genetics, proteomics as well as metabolomics.