George Bazoukis
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View article: The Role of Ventricular Arrhythmias Inducibility in Arrhythmic Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy: A Meta‐Analysis of Observational Studies
The Role of Ventricular Arrhythmias Inducibility in Arrhythmic Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy: A Meta‐Analysis of Observational Studies Open
Background The identification of arrhythmogenic right ventricular cardiomyopathy (ARVC) patients at risk for fatal arrhythmic events is of great importance in clinical practice. Conflicting data exist regarding the role of electrophysiolog…
View article: Use of artificial intelligence in predicting in-hospital cardiac and respiratory arrest in an acute care environment—implications for clinical practice
Use of artificial intelligence in predicting in-hospital cardiac and respiratory arrest in an acute care environment—implications for clinical practice Open
Background Artificial intelligence (AI)-based models can augment clinical decision-making, including prediction, diagnosis, and treatment, in all aspects of medicine. Research questions The current systematic review aims to provide a summa…
View article: Different left bundle branch block morphologies and response to CRT: a cohort study
Different left bundle branch block morphologies and response to CRT: a cohort study Open
Background Although left bundle branch block (LBBB) is a strong predictor of response to cardiac resynchronization therapy (CRT), a significant number of patients remain non-responders. Purpose The study sought to evaluate the impact of di…
View article: Clinical Significance and Management of Atrioventricular Block Associated With Bradycardic/Antiarrhythmic Drug Therapy: Drug‐Induced or Drug‐Revealed?
Clinical Significance and Management of Atrioventricular Block Associated With Bradycardic/Antiarrhythmic Drug Therapy: Drug‐Induced or Drug‐Revealed? Open
The development of advanced atrioventricular block (AVB) in patients on bradycardic and/or antiarrhythmic therapy (drug‐related AVB) represents a clinical challenge, raising the question of whether the AVB is directly caused by these agent…
View article: Impact of Social Determinants of Health on Cardiovascular Disease
Impact of Social Determinants of Health on Cardiovascular Disease Open
An increasing number of studies have shown the impact of social determinants of health (SDoHs) on different cardiovascular outcomes. SDoHs influence the regional incidence of heart failure, heart failure outcomes, and heart failure readmis…
View article: Clinical significance and management of atrioventricular block associated with bradycardic/antiarrhythmic drug therapy: Drug-induced or drug-revealed?
Clinical significance and management of atrioventricular block associated with bradycardic/antiarrhythmic drug therapy: Drug-induced or drug-revealed? Open
View article: Cardiac resynchronization therapy in heart failure based on Strauss criteria for left bundle branch block
Cardiac resynchronization therapy in heart failure based on Strauss criteria for left bundle branch block Open
Aims The left bundle branch block (LBBB) is a strong predictor of response to cardiac resynchronization therapy (CRT). However, a significant number of patients do not respond to the treatment. The study sought to evaluate the impact of th…
View article: Flecainide toxicity—Clinical diagnosis and management of an urgent condition
Flecainide toxicity—Clinical diagnosis and management of an urgent condition Open
Key Clinical Message Clinical suspicion, clinical presentation, and electrocardiogram can help clinicians diagnose flecainide toxicity. Currently, there are no guidelines for the management of patients with flecainide toxicity. Sodium bica…
View article: Efficacy of Commonly Used 3D Mapping Systems in Acute Success Rates of Catheter Ablation Procedures
Efficacy of Commonly Used 3D Mapping Systems in Acute Success Rates of Catheter Ablation Procedures Open
Introduction: This systematic review aims to summarize the procedural arrhythmia termination rates in catheter ablation (CA) procedures of atrial or ventricular arrhythmias using the commonly used mapping systems (CARTO, Rhythmia an…
View article: The Combination of Hyperuricemia and Elevated High-Sensitivity C-Reactive Protein Increased the Risk of Cardiac Conduction Block
The Combination of Hyperuricemia and Elevated High-Sensitivity C-Reactive Protein Increased the Risk of Cardiac Conduction Block Open
HUA combined with elevated hs-CRP increased the risk of CCB, especially AVB. The connection between UA and the CCB risk was partly mediated by hs-CRP.
View article: Strauss criteria for left bundle branch block in cardiac resynchronization therapy: improved response with lower ventricular arrhythmic burden
Strauss criteria for left bundle branch block in cardiac resynchronization therapy: improved response with lower ventricular arrhythmic burden Open
Objectives The study sought to evaluate the impact of the stricter Strauss criteria for left bundle branch block (St-LBBB) on cardiac resynchronization therapy (CRT) response, hospitalizations, ventricular arrhythmia (VA) events and mortal…
View article: Cardiovascular magnetic resonance 3D LGE imaging for atrial fibrillation ablation
Cardiovascular magnetic resonance 3D LGE imaging for atrial fibrillation ablation Open
Objective To assess feasibility and reliability of cardiac magnetic resonance (CMR) imaging in visualizing left atrial (LA) structural changes that patients with paroxysmal atrial fibrillation (PAF) undergo acutely and long-term post ablat…
View article: Diagnostic yield of implantable loop recorders: results from the hellenic registry
Diagnostic yield of implantable loop recorders: results from the hellenic registry Open
In this real-world patient population, ILR determines diagnosis and initiates new therapeutic management for nearly one-fourth of patients. ILR implantation is valuable in the evaluation of patients with unexplained presyncope/syncope, CS,…
View article: Analysis of the effectiveness of the latest 4th-generation cryoballoon catheters in pulmonary vein isolation using high-resolution mapping
Analysis of the effectiveness of the latest 4th-generation cryoballoon catheters in pulmonary vein isolation using high-resolution mapping Open
The utility of additional high-density mapping, facilitated by the HD Grid catheter after PVI with the 4th-generation cryoballoon catheter do not substantiate a discernible advantage over conventional mapping methodologies, particularly, t…
View article: Atrial Fibrillation and Dementia: Pathophysiological Mechanisms and Clinical Implications
Atrial Fibrillation and Dementia: Pathophysiological Mechanisms and Clinical Implications Open
Numerous longitudinal studies suggest a strong association between cardiovascular risk factors and cognitive impairment. Individuals with atrial fibrillation are at higher risk of dementia and cognitive dysfunction, as atrial fibrillation …
View article: PR prolongation as a predictor of atrial fibrillation onset: A state-of-the-art review
PR prolongation as a predictor of atrial fibrillation onset: A state-of-the-art review Open
First-degree atrioventricular block (1-AVB), characterized by a PR interval exceeding 200 milliseconds, has traditionally been perceived as a benign cardiac condition. Recently, this perception has been challenged by investigations that in…
View article: Interpretable machine learning model using Extreme Gradient Boosting with Nonnegative Matrix Factorization improves the accuracy of arrhythmic risk prediction in Brugada Syndrome
Interpretable machine learning model using Extreme Gradient Boosting with Nonnegative Matrix Factorization improves the accuracy of arrhythmic risk prediction in Brugada Syndrome Open
Background Both depolarization and repolarization abnormalities contribute to ventricular arrhythmogenesis in Brugada syndrome (BrS). In this study, we tested the hypothesis that incorporating latent features extracted by various nonnegati…
View article: An inappropriately–appropriate ICD therapy: What is the mechanism and what interventions can be done?
An inappropriately–appropriate ICD therapy: What is the mechanism and what interventions can be done? Open
Key Clinical Message R‐wave double counting is a rare cause of ventricular oversensing that can lead to inappropriate shocks. Optimizing device programming is essential for the avoidance of subsequent inappropriate therapies. Abstract R‐wa…
View article: Vagus Nerve Stimulation and Inflammation in Cardiovascular Disease: A State‐of‐the‐Art Review
Vagus Nerve Stimulation and Inflammation in Cardiovascular Disease: A State‐of‐the‐Art Review Open
Vagus nerve stimulation (VNS) has been found to exert anti‐inflammatory effects in different clinical settings and has been associated with improvement of clinical outcomes. However, evidence on the mechanistic link between the potential a…
View article: Cardioneuroablation for neurally-mediated syncope: Initial experience
Cardioneuroablation for neurally-mediated syncope: Initial experience Open
Cardioneuroablation is an emerging alternative therapeutic modality for young patients with severe neurally-mediated syncope. We present two images of cardioneuroablation performed in young patients who suffered from recurrent neurally-med…
View article: Secular trends of health care resource utilization and costs between Brugada syndrome and congenital long QT syndrome: A territory‐wide study
Secular trends of health care resource utilization and costs between Brugada syndrome and congenital long QT syndrome: A territory‐wide study Open
Background Health care resource utilization (HCRU) and costs are important metrics of health care burden, but they have rarely been explored in the setting of cardiac ion channelopathies. Hypothesis This study tested the hypothesis that at…
View article: Noncompaction Cardiomyopathy and Embolic Events
Noncompaction Cardiomyopathy and Embolic Events Open
Left ventricular noncompaction cardiomyopathy (LVNC) is characterized by prominent ventricular trabeculations and deep intertrabecular recesses. Patients with LVNC have an increased risk of embolic events. The presence of symptoms at the t…
View article: Virtual medical research mentoring
Virtual medical research mentoring Open
Background Medical research is important for professional advancement, and mentoring is a key means by which students and early‐career doctors can engage in research. Contrasting international research collaborations, research mentoring pr…
View article: Radiofrequency versus cryoballoon catheter ablation in patients with persistent atrial fibrillation: A randomized trial
Radiofrequency versus cryoballoon catheter ablation in patients with persistent atrial fibrillation: A randomized trial Open
Introduction Patients with persistent atrial fibrillation (AF) represent a challenging population for rhythm control therapies. Catheter ablation (CA) with pulmonary vein isolation (PVI) is an effective treatment option for the reduction o…
View article: Left ventricular thrombus in a patient with recurrent ischemic stroke events—The role of echocardiography
Left ventricular thrombus in a patient with recurrent ischemic stroke events—The role of echocardiography Open
Key Clinical Message Cardiac ultrasound is recommended in investigating ischemic stroke events. There is increasing evidence that direct oral anticoagulants can be safely used instead of vitamin K antagonists in the setting of left ventric…
View article: Application of artificial intelligence in the diagnosis of sleep apnea
Application of artificial intelligence in the diagnosis of sleep apnea Open
View article: Phosphorus Magnetic Resonance Spectroscopy (31P MRS) and Cardiovascular Disease: The Importance of Energy
Phosphorus Magnetic Resonance Spectroscopy (31P MRS) and Cardiovascular Disease: The Importance of Energy Open
Background and Objectives: The heart is the organ with the highest metabolic demand in the body, and it relies on high ATP turnover and efficient energy substrate utilisation in order to function normally. The derangement of myocardial ene…
View article: Historical perspective and recent progress in cardiac ion channelopathies research and clinical practice in Hong Kong
Historical perspective and recent progress in cardiac ion channelopathies research and clinical practice in Hong Kong Open
Cardiac ion channelopathies encompass a set of inherited or acquired conditions that are due to dysfunction in ion channels or their associated proteins, typically in the presence of structurally normal hearts. They are associated with the…
View article: Association between Sick Sinus Syndrome and Atrial Fibrillation: A Systematic Review and Meta-Analysis
Association between Sick Sinus Syndrome and Atrial Fibrillation: A Systematic Review and Meta-Analysis Open
View article: Contemporary management of ventricular arrhythmias in heart failure.
Contemporary management of ventricular arrhythmias in heart failure. Open
Enhanced ventricular arrhythmogenesis is commonly experienced by patients in the end-stage of heart failure spectrum. A high burden of ventricular arrhythmias can affect the ventricular systolic function, lead to unexpected hospitalization…