George E. Allen
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View article: Reprogramming neuroblastoma by diet-enhanced polyamine depletion
Reprogramming neuroblastoma by diet-enhanced polyamine depletion Open
View article: High-throughput bioprinting to produce micropatterned neuroepithelial tissues and model TSC2-deficient brain malformations
High-throughput bioprinting to produce micropatterned neuroepithelial tissues and model TSC2-deficient brain malformations Open
In vitro human pluripotent stem cell (hPSC)-derived models have been crucial in advancing our understanding of the mechanisms underlying neurodevelopment, though knowledge of the earliest stages of brain formation is lacking. Micropatterni…
View article: A bioprinting approach for high-throughput production of micropatterned neuroepithelial tissues and modeling TSC2-deficient brain malformations
A bioprinting approach for high-throughput production of micropatterned neuroepithelial tissues and modeling TSC2-deficient brain malformations Open
Summary In vitro human pluripotent stem cell-derived models have been crucial in advancing our understanding of the mechanisms underlying neurodevelopment, though knowledge of the earliest stages of brain formation is lacking. Micropattern…
View article: Critical functions and key interactions mediated by the RNase E scaffolding domain in Pseudomonas aeruginosa
Critical functions and key interactions mediated by the RNase E scaffolding domain in Pseudomonas aeruginosa Open
The RNA degradosome is a bacterial multi-protein complex mediating mRNA processing and degradation. In Pseudomonadota, this complex assembles on the C-terminal domain (CTD) of RNase E through short linear motifs (SLiMs) that determine its …
View article: A Bioprinting Approach for High-Throughput Production of Micropatterned Neuroepithelial Tissues And Modeling TSC2-Deficient Brain Malformations
A Bioprinting Approach for High-Throughput Production of Micropatterned Neuroepithelial Tissues And Modeling TSC2-Deficient Brain Malformations Open
View article: Cytosolic <i>N6AMT1-</i> dependent translation supports mitochondrial RNA processing
Cytosolic <i>N6AMT1-</i> dependent translation supports mitochondrial RNA processing Open
Mitochondrial biogenesis relies on both the nuclear and mitochondrial genomes, and imbalance in their expression can lead to inborn errors of metabolism, inflammation, and aging. Here, we investigate N6AMT1, a nucleo-cytosolic methyltransf…
View article: Critical functions and key interactions mediated by the RNase E scaffolding domain in<i>Pseudomonas aeruginosa</i>
Critical functions and key interactions mediated by the RNase E scaffolding domain in<i>Pseudomonas aeruginosa</i> Open
The RNA degradosome is a bacterial multi-protein complex mediating mRNA processing and degradation. In Pseudomonadota, this complex assembles on the C-terminal domain (CTD) of RNase E through short linear motifs (SLiMs) that determine its …
View article: Cytosolic N6AMT1-dependent translation supports mitochondrial RNA processing
Cytosolic N6AMT1-dependent translation supports mitochondrial RNA processing Open
Summary Mitochondrial biogenesis relies on both the nuclear and mitochondrial genomes, and imbalance in their expression can lead to inborn error of metabolism, inflammation, and aging. Here, we investigate N6AMT1, a nucleo-cytosolic methy…
View article: Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria
Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria Open
RNA helicases—central enzymes in RNA metabolism—often feature intrinsically disordered regions (IDRs) that enable phase separation and complex molecular interactions. In the bacterial pathogen Pseudomonas aeruginosa, the non-redundant RhlE…
View article: Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria
Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria Open
RNA helicases—central enzymes in RNA metabolism— often feature intrinsically disordered regions (IDRs) that enable phase separation and complex molecular interactions. In the bacterial pathogen Pseudomonas aeruginosa , the non-redundant Rh…
View article: Reprogramming neuroblastoma by diet-enhanced polyamine depletion
Reprogramming neuroblastoma by diet-enhanced polyamine depletion Open
Summary Neuroblastoma is a highly lethal childhood tumor derived from differentiation-arrested neural crest cells 1,2 . Like all cancers, its growth is fueled by metabolites obtained from either circulation or local biosynthesis 3,4 . Neur…
View article: Not4-dependent targeting of <i>MMF1</i> mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy
Not4-dependent targeting of <i>MMF1</i> mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy Open
The Ccr4–Not complex is a conserved multi protein complex with diverse roles in the mRNA life cycle. Recently we determined that the Not1 and Not4 subunits of Ccr4–Not inversely regulate mRNA solubility and thereby impact dynamics of co-tr…
View article: Supplementary Figure 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Figure 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 185K, Representative HRM curves of a NKTCL case confirmed as heterozygous JAK3A573V mutation
View article: Supplementary Table 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Table 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 75K, Sequence analysis summary of tumor and blood samples from four NKTCL cases
View article: Supplementary Table 3 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Table 3 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 83K, JAK1 and JAK3 mutation status in NKTCL cases
View article: Data from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Data from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome sequencing and identified Janus kinase 3 (JAK3) somatic–activating mutations (A572V and A573V) in 2 of 4 pa…
View article: Supplementary Table 2 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Table 2 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 110K, Non-synonymous somatic mutations identified in the Discovery set of four NKTCL cases
View article: Supplementary Table 3 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Table 3 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 83K, JAK1 and JAK3 mutation status in NKTCL cases
View article: Supplementary Figure 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Figure 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 185K, Representative HRM curves of a NKTCL case confirmed as heterozygous JAK3A573V mutation
View article: Supplementary Table 4 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Table 4 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 74K, Primer sets used for Sanger sequencing and HRM analysis
View article: Supplementary Table 4 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Table 4 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 74K, Primer sets used for Sanger sequencing and HRM analysis
View article: Supplementary Table 2 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Table 2 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 110K, Non-synonymous somatic mutations identified in the Discovery set of four NKTCL cases
View article: Data from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Data from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome sequencing and identified Janus kinase 3 (JAK3) somatic–activating mutations (A572V and A573V) in 2 of 4 pa…
View article: Supplementary Table 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Supplementary Table 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma Open
PDF file - 75K, Sequence analysis summary of tumor and blood samples from four NKTCL cases
View article: Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events
Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events Open
View article: Additional file 2 of Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events
Additional file 2 of Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events Open
Additional file 2: Table S1. 5’P-Seq and RNA-Seq of soluble and total RNA pools before and after depletion of Not1, Not4 and Not5.
View article: Additional file 5 of Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events
Additional file 5 of Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events Open
Additional file 5: Table S4. Not1-ChEC-Seq.
View article: Lauerwald et al. 2023 GBC Repository.xlsx
Lauerwald et al. 2023 GBC Repository.xlsx Open
This data set represents a collection of previously published global scale estimates of inland water greenhouse gas (carbon dioxide, methane, nitrous oxide) emissions. The estimates are listed together with literature refrences. The data w…
View article: Additional file 4 of Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events
Additional file 4 of Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events Open
Additional file 4: Table S3. Not4 and RNAPII PAR-CLIP.
View article: Additional file 3 of Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events
Additional file 3 of Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events Open
Additional file 3: Table S2. Changes in solubility upon Not1, Not4 and Not5 depletion.