Guimin Gao
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Size and Shape Effects on Mass Concrete Strength: Experimental Evaluation and Model Development Open
This study investigates the influence of specimen size and shape on the compressive strength of mass concrete, aiming to develop a robust predictive model for large-scale structural applications, particularly in hydraulic and foundation en…
VLMgineer: Vision Language Models as Robotic Toolsmiths Open
Tool design and use reflect the ability to understand and manipulate the physical world through creativity, planning, and foresight. As such, these capabilities are often regarded as measurable indicators of intelligence across biological …
View article: Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia
Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia Open
BACKGROUND: Expansion of genome-wide association studies across population groups is needed to improve our understanding of shared and unique genetic contributions to breast cancer. We performed association and replication studies guided b…
Out-of-Distribution Recovery with Object-Centric Keypoint Inverse Policy for Visuomotor Imitation Learning Open
We propose an object-centric recovery (OCR) framework to address the challenges of out-of-distribution (OOD) scenarios in visuomotor policy learning. Previous behavior cloning (BC) methods rely heavily on a large amount of labeled data cov…
View article: Gene‐based association tests in family samples using GWAS summary statistics
Gene‐based association tests in family samples using GWAS summary statistics Open
Genome‐wide association studies (GWAS) have led to rapid growth in detecting genetic variants associated with various phenotypes. Owing to a great number of publicly accessible GWAS summary statistics, and the difficulty in obtaining indiv…
View article: Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia
Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia Open
Background Expansion of genome-wide association studies across population groups is needed to improve our understanding of shared and unique genetic contributions to breast cancer. We performed association and replication studies guided by…
A splicing-based multi-tissue joint transcriptome-wide association study identifies susceptibility genes for breast cancer Open
Splicing-based transcriptome-wide association studies (splicing-TWASs) of breast cancer have the potential to identify new susceptibility genes. However, existing splicing-TWASs test association of individual excised introns in breast tiss…
View article: Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: A cross-ancestry approach
Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: A cross-ancestry approach Open
Polygenic risk scores (PRSs) are useful for predicting breast cancer risk, but the prediction accuracy of existing PRSs in women of African ancestry (AA) remains relatively low. We aim to develop optimal PRSs for the prediction of overall …
Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women Open
Our study describes breast cancer risk loci using a cross-ancestry GWAS approach. We first identify variants that are associated with breast cancer at P < 0.05 from African ancestry GWAS meta-analysis (9241 cases and 10193 controls), then …
Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry Open
Background: Polygenic risk scores (PRSs) have been demonstrated to identify women of European, Asian, and Latino ancestry at elevated risk of developing breast cancer (BC). We evaluated the performance of existing PRSs trained in European …
MOVER-R and Penalized MOVER-R Confidence Intervals for the Ratio of Two Quantities Open
Developing a confidence interval for the ratio of two quantities is an important task in statistics because of its omnipresence in real world applications. For such a problem, the MOVER-R (method of variance recovery for the ratio) techniq…
MOVER-R and Penalized MOVER-R Confidence Intervals for the Ratio of Two Quantities Open
Developing a confidence interval for the ratio of two quantities is an important task in statistics because of its omnipresence in real world applications. For such a problem, the MOVER-R (method of variance recovery for the ratio) techniq…
A joint transcriptome-wide association study across multiple tissues identifies new candidate susceptibility genes for breast cancer Open
Genome-wide association studies (GWAS) have identified more than 200 genomic loci for breast cancer risk, but specific causal genes in most of these loci have not been identified. In fact, transcriptome-wide association studies (TWAS) of b…
Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies Open
There is increasing recognition that pathogenic germ line variants drive the development of hematopoietic cancers in many individuals. Currently, patients with hereditary hematologic malignancies (HHMs) receive similar standard therapies a…
View article: Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach
Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach Open
Polygenic risk scores (PRSs) are useful for predicting breast cancer risk, but the prediction accuracy of existing PRSs in women of African ancestry (AA) remains relatively low. We aim to develop optimal PRSs for the prediction of overall …
Polygenic Risk Scores for Prediction of Breast Cancer Risk in Women of African Ancestry: a Cross-Ancestry Approach Open
Polygenic risk scores (PRSs) are useful to predict breast cancer risk, but the prediction accuracy of existing PRSs in women of African ancestry (AA) remain relatively low. We aim to develop optimal PRSs for prediction of overall and estro…
Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi‐phased study of prostate cancer Open
Background DNA methylation and gene expression are known to play important roles in the etiology of human diseases such as prostate cancer (PCa). However, it has not yet been possible to incorporate information of DNA methylation and gene …
Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry Open
Background Polygenic risk scores (PRSs) have been demonstrated to identify women of European, Asian, and Latino ancestry at elevated risk of developing breast cancer (BC). We evaluated the performance of existing PRSs trained in European a…
View article: Methylome-Wide Association Study of Schizophrenia: Identifying Blood Biomarker Signatures of Environmental Insults
Methylome-Wide Association Study of Schizophrenia: Identifying Blood Biomarker Signatures of Environmental Insults Open
Epigenetic studies present unique opportunities to advance schizophrenia research because they can potentially account for many of its clinical features and suggest novel strategies to improve disease management.
Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use Open
BACKGROUND: Methylome-wide association (MWAS) studies present a new way to advance the search for biological correlates for alcohol use. A challenge with methylation studies of alcohol involves the causal direction of significant methylati…
Penalized Fieller's confidence interval for the ratio of bivariate normal means Open
Constructing a confidence interval for the ratio of bivariate normal means is a classical problem in statistics. Several methods have been proposed in the literature. The Fieller method is known as an exact method, but can produce an unbou…
View article: Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses
Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses Open
Genome-wide association study meta-analyses have robustly implicated three loci that affect susceptibility for smoking: CHRNA5\CHRNA3\CHRNB4, CHRNB3\CHRNA6 and EGLN2\CYP2A6. Functional follow-up studies of these loci are needed to provide …