George I. Jallo
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View article: Data from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
Data from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM Open
Patients with radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an invasive and dange…
View article: Supplementary Tables S1-S19 from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
Supplementary Tables S1-S19 from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM Open
Supplementary Table S1: Cohorts for CSF-BAM components. Supplementary Table S2A: SafeBSeqS primer sequences. Supplementary Table S2B: SafeTseqS primer sequences. Supplementary Table S2C: Aneuploidy analysis primer sequences. Supplementary …
View article: Supplementary Figures S1-S9 from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
Supplementary Figures S1-S9 from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM Open
Supplementary Figure S1. SafeBSeqS amplification. Supplementary Figure S2. SafeTSeqS amplification. Supplementary Figure S3. Aneuploidy reproducibility from two independent aliquots and libraries. Supplementary Figure S4. Metrics for targe…
View article: P10.02.A CAR-T CELL-DERIVED EXOSOMES LOADED WITH THERAPEUTIC SIRNA IS A PROMISING TECHNIQUE IN THE TREATMENT OF SUBGROUP 3 MEDULLOBLASTOMA
P10.02.A CAR-T CELL-DERIVED EXOSOMES LOADED WITH THERAPEUTIC SIRNA IS A PROMISING TECHNIQUE IN THE TREATMENT OF SUBGROUP 3 MEDULLOBLASTOMA Open
BACKGROUND Medulloblastoma (MB) is a life-threatening childhood tumor that occurs in the cerebellum. This tumor showed resistance against several types of immunotherapies like anti-PD1, cancer vaccines, monoclonal antibodies (mAbs), and ev…
View article: Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM Open
Patients with radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an invasive and dange…
View article: Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years
Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years Open
Purpose: Intramedullary spinal cord tumors (IMSCTs) account for 2–8% of all primary CNS tumors, with ependymal tumors astrocytic tumors and hemangioblastoma being the most prevalent. Due to scarcity of large-scale studies, we aim to provid…
View article: Open Versus Endoscopic Surgery with Helmet Molding Therapy in Non-syndromic Patients with Craniosynostosis: An Updated Systematic Review and Meta-Analysis of Clinical Outcomes and Treatment-Related Costs
Open Versus Endoscopic Surgery with Helmet Molding Therapy in Non-syndromic Patients with Craniosynostosis: An Updated Systematic Review and Meta-Analysis of Clinical Outcomes and Treatment-Related Costs Open
Objective There is an ongoing debate regarding the optimal treatment for craniosynostosis as diverse factors influence the election between endoscopic and open surgery. Previous evidence favors endoscopic procedures; However, evidence rema…
View article: Detection of human brain cancers using genomic and immune cell characterization of cerebrospinal fluid through CSF-BAM
Detection of human brain cancers using genomic and immune cell characterization of cerebrospinal fluid through CSF-BAM Open
Patients who have radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an obviously inva…
View article: Systematic transcriptomic analysis of childhood medulloblastoma identifies N6-methyladenosine-dependent lncRNA signatures associated with molecular subtype, immune cell infiltration, and prognosis
Systematic transcriptomic analysis of childhood medulloblastoma identifies N6-methyladenosine-dependent lncRNA signatures associated with molecular subtype, immune cell infiltration, and prognosis Open
Medulloblastoma, the most common malignant pediatric brain tumor, is classified into four main molecular subgroups, but group 3 and group 4 tumors are difficult to subclassify and have a poor prognosis. Rapid point-of-care diagnostic and p…
View article: MDB-70. SYSTEMATIC TRANSCRIPTOMIC ANALYSIS OF CHILDHOOD MEDULLOBLASTOMA IDENTIFIES M6A-LNCRNA SIGNATURES ASSOCIATED WITH PROGNOSIS, MOLECULAR SUBTYPE, AND IMMUNE CELL INFILTRATION
MDB-70. SYSTEMATIC TRANSCRIPTOMIC ANALYSIS OF CHILDHOOD MEDULLOBLASTOMA IDENTIFIES M6A-LNCRNA SIGNATURES ASSOCIATED WITH PROGNOSIS, MOLECULAR SUBTYPE, AND IMMUNE CELL INFILTRATION Open
BACKGROUND Medulloblastoma (MB) is the predominant pediatric brain tumor, subdivided into four molecular subgroups, with group 3 and group 4 tumors posing significant clinical challenges due to poor prognosis and classification. This study…
View article: MDB-01. A POSITIVE FEEDBACK LOOP BETWEEN<i>LNC-HLX-2-7</i>, HLX, AND MYC STRONGLY PROMOTES GROUP 3 MEDULLOBLASTOMA
MDB-01. A POSITIVE FEEDBACK LOOP BETWEEN<i>LNC-HLX-2-7</i>, HLX, AND MYC STRONGLY PROMOTES GROUP 3 MEDULLOBLASTOMA Open
Recent studies suggest that long non-coding RNAs (lncRNAs) contribute to medulloblastoma formation and progression. We have identified a lncRNA, lnc-HLX-2-7, as a potential therapeutic target in group 3 (G3) medulloblastomas. lnc-HLX-2-7 R…
View article: Association of limited dorsal myeloschizis and corpus callosum lipoma: A case report and literature review
Association of limited dorsal myeloschizis and corpus callosum lipoma: A case report and literature review Open
Background: Intracranial lipomas are a rare clinical entity. These lesions are frequently asymptomatic and originate in the pericallosal area. As they are fat-containing lesions which are intimately attached to the surrounding structures, …
View article: The role of occipital condyle and atlas anomalies on occipital cervical fusion outcomes in Chiari malformation type I with syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium
The role of occipital condyle and atlas anomalies on occipital cervical fusion outcomes in Chiari malformation type I with syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium Open
OBJECTIVE Congenital anomalies of the atlanto-occipital articulation may be present in patients with Chiari malformation type I (CM-I). However, it is unclear how these anomalies affect the biomechanical stability of the craniovertebral ju…
View article: A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma
A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma Open
Recent studies suggest that long non-coding RNAs (lncRNAs) contribute to medulloblastoma (MB) formation and progression. We have identified an lncRNA, lnc-HLX-2-7, as a potential therapeutic target in group 3 (G3) MBs. lnc-HLX-2-7 RNA spec…
View article: miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4
miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4 Open
The prognosis of childhood medulloblastoma (MB) is often poor, and it usually requires aggressive therapy that adversely affects quality of life. microRNA-211 (miR-211) was previously identified as an important regulator of cells that desc…
View article: Added value of corpus callosotomy following vagus nerve stimulation in children with <scp>Lennox–Gastaut</scp> syndrome: A multicenter, multinational study
Added value of corpus callosotomy following vagus nerve stimulation in children with <span>Lennox–Gastaut</span> syndrome: A multicenter, multinational study Open
Objective Lennox–Gastaut syndrome (LGS) is a severe form of epileptic encephalopathy, presenting during the first years of life, and is very resistant to treatment. Once medical therapy has failed, palliative surgeries such as vagus nerve …
View article: The impact of the COVID pandemic on publication disciplines among major general medical journals: A bibliometric analysis using natural language processing and traditional statistics
The impact of the COVID pandemic on publication disciplines among major general medical journals: A bibliometric analysis using natural language processing and traditional statistics Open
Introduction: The COVID-19 pandemic has altered the design, conduct, and dissemination of medical and scientific research; yet, little is known regarding the changes in publication trends as a result of the pandemic. The principal objectiv…
View article: Approaches to Incidental Intradural Tumors of the Spine in the Pediatric Population
Approaches to Incidental Intradural Tumors of the Spine in the Pediatric Population Open
Background: Incidental intradural tumors of the spine in the pediatric population are rare lesions whose management remains unclear. Surgeons must balance the risks of iatrogenic deficits and complications after surgical resection against …
View article: Advances in Imaging Modalities for Pediatric Brain and Spinal Cord Tumors
Advances in Imaging Modalities for Pediatric Brain and Spinal Cord Tumors Open
Background: Neuroimaging has evolved from anatomical imaging toward a multi-modality comprehensive anatomical and functional imaging in the past decades, important functional data like perfusion-weighted imaging, permeability imaging, diff…
View article: Knowledge Review of Spinal Deformity and the Need for Fusion and Fixation following Treatment for Spinal Tumors among the Pediatric Age Group
Knowledge Review of Spinal Deformity and the Need for Fusion and Fixation following Treatment for Spinal Tumors among the Pediatric Age Group Open
Background: Spinal tumors are rare pathology in the pediatric population. The tumors can be classified as extradural, intradural extramedullary, or intramedullary. Any of the spinal tumors can eventually lead to spinal deformity. The progr…
View article: DDDR-31. THE THERAPEUTIC POTENTIAL OF THE LONG NON-CODING RNA LNC-HLX-2-7 IN GROUP 3 MEDULLOBLASTOMAS IN CHILDREN
DDDR-31. THE THERAPEUTIC POTENTIAL OF THE LONG NON-CODING RNA LNC-HLX-2-7 IN GROUP 3 MEDULLOBLASTOMAS IN CHILDREN Open
Medulloblastoma (MB) is an aggressive brain tumor that predominantly affects children. Recent high-throughput sequencing studies suggest that the non-coding RNA genome, in particular long non-coding RNAs (lncRNAs), contributes to MB format…
View article: EXTH-80. THE MOLECULAR FUNCTION AND THE THERAPEUTIC POTENTIAL OF MICRORNA-211 IN GROUP 3 MEDULLOBLASTOMAS IN CHILDREN
EXTH-80. THE MOLECULAR FUNCTION AND THE THERAPEUTIC POTENTIAL OF MICRORNA-211 IN GROUP 3 MEDULLOBLASTOMAS IN CHILDREN Open
Medulloblastoma is a central nervous system tumor that primarily affects children and requires aggressive therapy. Patients often suffer from treatment-related side effects, and treatment-resistant recurrences are common, with high mortali…
View article: BIOM-50. THE IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CIRCULAR RNA CIRC_63706 IN SONIC HEDGEHOG MEDULLOBLASTOMAS
BIOM-50. THE IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CIRCULAR RNA CIRC_63706 IN SONIC HEDGEHOG MEDULLOBLASTOMAS Open
Medulloblastoma is a central nervous system tumor that develops through various genetic, epigenetic, and non-coding (nc) RNA-related mechanisms, but the roles played by ncRNAs, particularly circular RNAs (circRNAs), remain poorly defined. …
View article: Surgical approaches to intramedullary spinal cord astrocytomas in the age of genomics
Surgical approaches to intramedullary spinal cord astrocytomas in the age of genomics Open
Intramedullary astrocytomas represent approximately 30%–40% of all intramedullary tumors and are the most common intramedullary tumor in children. Surgical resection is considered the mainstay of treatment in symptomatic patients with neur…
View article: MEDB-02. The identification and functional characterization of circular RNA Circ_63706 in sonic hedgehog medulloblastomas
MEDB-02. The identification and functional characterization of circular RNA Circ_63706 in sonic hedgehog medulloblastomas Open
Circular RNAs (circRNAs) are increasingly recognized as stable and specific biomarkers and therapeutic targets in many cancers, but little is known about their function, subtype specificity, and biomarker potential in medulloblastomas. Med…
View article: MEDB-03. Medulloblastoma cerebrospinal fluid reveals hypoxic indicators (metabolites and lipids) and cancer-specific RNAs
MEDB-03. Medulloblastoma cerebrospinal fluid reveals hypoxic indicators (metabolites and lipids) and cancer-specific RNAs Open
Medulloblastoma (MB) is the most common malignant brain tumor in children. There remains an unmet need for diagnostics to sensitively detect the disease, particularly recurrences. Cerebrospinal fluid (CSF) provides a window into the centra…