George Iancu
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View article: Visual Function Improvement after Plasma Exchange Therapy for Acute Optic Neuritis in Neuromyelitis Optica Spectrum Disorders: Case Series and Review
Visual Function Improvement after Plasma Exchange Therapy for Acute Optic Neuritis in Neuromyelitis Optica Spectrum Disorders: Case Series and Review Open
Objective: Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune-mediated central nervous system disorders distinguished by the presence of serum aquaporine-4 IgG antibody (AQP4-Ab). The clinical pane…
View article: Evaluation of quality of life and socio-emotional impact of oncological treatment among patients with breast cancer
Evaluation of quality of life and socio-emotional impact of oncological treatment among patients with breast cancer Open
Breast cancer is the most frequent cancer in women worldwide. Quality of life (QoL) is significantly affected by both surgical and oncological treatment. The aim of this study was to assess and compare QoL, resilience and depression scores…
View article: Ocular adverse effects of anti-cancer chemotherapy
Ocular adverse effects of anti-cancer chemotherapy Open
Cancer ranks as the second leading cause of mortality in Europe, following cardiovascular diseases. Every year, 2.6 million people are diagnosed with this disease, and 1.2 million die. It has an impact not only on individual health but als…
View article: Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications
Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications Open
Ehlers–Danlos syndromes (EDS) represent a group of rare inherited disorders that affect connective tissues. There are 13 types of disease, most of them affecting joints or skin; symptoms usually include loose joints, joint pain, stretchy v…
View article: Highlights on Genetic Polymorphism Associated with Thromboembolic Risk; Implications in Ophthalmic and Autoimmune Disorders—A Review
Highlights on Genetic Polymorphism Associated with Thromboembolic Risk; Implications in Ophthalmic and Autoimmune Disorders—A Review Open
The present paper explores genetic polymorphism and its association with thromboembolic retinal venous disorders, such as central/hemi-retinal vein occlusion, as well as possible correlations with other ocular findings, such as closed angl…
View article: COVID-19 in pregnancy – a possible risk factor for the poor neurological outcome of the infant
COVID-19 in pregnancy – a possible risk factor for the poor neurological outcome of the infant Open
View article: Vitamin D supplementation – still a subject of debate
Vitamin D supplementation – still a subject of debate Open
Vitamin D is a standard vitamin supplementation for children in many countries, used mainly for preventing rickets. Many studies were published about the efficiency of vitamin D administration in children and adults for other pathologies b…
View article: Pre-COVID19 pandemia vaccines could have a nonspecific effect in preventing SARS-CoV-2 infection in the pediatric population
Pre-COVID19 pandemia vaccines could have a nonspecific effect in preventing SARS-CoV-2 infection in the pediatric population Open
The COVID-19 pandemic raised an unexpected challenge for the medicine and pharmaceutical industry. The primary goal in a short timeframe was to fight the spreading of SARS-CoV-2 by any means, starting from social distancing, wearing face m…
View article: Probiotics effect in prevention and treatment of atopic dermatitis and eczema in children
Probiotics effect in prevention and treatment of atopic dermatitis and eczema in children Open
The composition of the intestinal microbiota plays an important role in the occurrence of allergies. Based on the immunomodulating capabilities of bacteria, various studies have investigated the potential role of probiotics in the preventi…
View article: <i>In Vivo</i> Sentinel Lymph Node Detection with Indocyanine Green in Colorectal Cancer.
<i>In Vivo</i> Sentinel Lymph Node Detection with Indocyanine Green in Colorectal Cancer. Open
Introduction: The indocyanine green fluorescence imaging system allows the identification of lymphatic vessels, lymph nodes and blood flow during surgery. Colorectal cancer is the second commonest cancer in women, the third in men, …
View article: Risk of Subsequent Hysterectomy after Expectant Management in the Treatment of Placenta Accreta Spectrum Disorders
Risk of Subsequent Hysterectomy after Expectant Management in the Treatment of Placenta Accreta Spectrum Disorders Open
Management strategies for pregnancies with abnormal adherence/invasion of the placenta (placenta accreta spectrum, PAS) vary between centers. Expectant management (EM), defined as leaving the placenta in situ after the delivery of the baby…
View article: Management of patients with unruptured cerebral arteriovenous malformations during pregnancy and childbirth
Management of patients with unruptured cerebral arteriovenous malformations during pregnancy and childbirth Open
Cerebral arteriovenous malformations (AVM) are fistulous connections between arterial and venous blood flow, consisting of an abnormal tangle of dysplastic arteries and veins, without capillary vessels or interposed functional brain parenc…
View article: Medulloblastoma Presenting as Severe Headache during Pregnancy: A Case Report and Review of the Literature
Medulloblastoma Presenting as Severe Headache during Pregnancy: A Case Report and Review of the Literature Open
Headache is a common complaint during pregnancy and the puerperium. The differentiation between a benign headache and a headache that has an underlying more endangering cause, such as an intracranial tumor, can be difficult and often requi…
View article: Consequences of premature birth on dental health
Consequences of premature birth on dental health Open
Preterm infants are a special category of patients known for high rates of associated morbidities. This morbidities range from breathing problems to motor and neurologic impairments. The survival rates are improving along with better neona…
View article: Gestational periodontitis impact on the fetus and neonate
Gestational periodontitis impact on the fetus and neonate Open
Maternal oral pathologies during pregnancy represent a controversial subject. The incidence of periodontal disease is approximatively 40% among pregnant women. Periodontal disease has been associated with several unfortunate outcomes; amon…
View article: Tyrosine kinase inhibitors in breast cancer (Review)
Tyrosine kinase inhibitors in breast cancer (Review) Open
Anti-epidermal growth factor receptor (EGFR)-targeted therapy has been intensely researched in the last years, motivated by the favorable results obtained with monoclonal antibodies in HER2-enriched breast cancer (BC) patients. Most resear…
View article: Role of methylene blue in detecting the sentinel lymph node in colorectal cancer: <i>In vivo</i> vs. <i>ex vivo</i> technique
Role of methylene blue in detecting the sentinel lymph node in colorectal cancer: <i>In vivo</i> vs. <i>ex vivo</i> technique Open
The identification of sentinel lymph nodes is a valuable oncological method, which aims at mapping lymphatic drainage and has the advantage of correctly staging the disease and assessing prognosis. Lymph node invasion is an important progn…
View article: Impact of modern personalized treatment of breast cancer on surgical attitude and outcomes
Impact of modern personalized treatment of breast cancer on surgical attitude and outcomes Open
Multimodal treatment of breast cancer has made steady progress in recent years. The involvement of modern oncology, diagnostic imaging techniques and surgical treatment, have brought a definite benefit to patients, defining the multidiscip…
View article: Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review Open
Background and objectives: Rosai–Dorfman disease (RDD) is a type of histiocytosis that usually appears in young adults or children as bilateral cervical lymphadenopathy, but extranodal involvement in not uncommon. Although the pathogenesis…
View article: Developing Core Outcome Sets (COS) and Core Outcome Measures Sets (COMS) in Cosmetic Gynecological Interventions: Protocol for a Development and Usability Study
Developing Core Outcome Sets (COS) and Core Outcome Measures Sets (COMS) in Cosmetic Gynecological Interventions: Protocol for a Development and Usability Study Open
Background Studies evaluating cosmetic gynecological interventions have followed variable methodology and reported a diversity of outcomes. Such variations limit the comparability of studies and the value of research-based evidence. The de…
View article: Myelomeningocele Surgery over the 10 Years Following the MOMS Trial: A Systematic Review of Outcomes in Prenatal versus Postnatal Surgical Repair
Myelomeningocele Surgery over the 10 Years Following the MOMS Trial: A Systematic Review of Outcomes in Prenatal versus Postnatal Surgical Repair Open
Background and Objectives: Myelomeningocele is the most severe form of spina bifida, a congenital neural tube defect arising from an incomplete neural tube closure during early development with damage worsening with advancing gestational a…
View article: Docetaxel for Breast Cancer Treatment-Side Effects on Ocular Surface, a Systematic Review
Docetaxel for Breast Cancer Treatment-Side Effects on Ocular Surface, a Systematic Review Open
Docetaxel is a very effective chemotherapeutic agent for the treatment of metastatic or locally advanced breast cancer. Epiphora (hyperlacrimation) has been shown to be the most common eye condition in patients receiving docetaxel-based ch…
View article: COVID-19 Pandemic Impact on Cord Blood Collection for Stem Cell Use and Actual Perspectives
COVID-19 Pandemic Impact on Cord Blood Collection for Stem Cell Use and Actual Perspectives Open
Cord blood collection for stem cell storage remains a popular procedure due to the advantages associated to it. In the last ten years, the therapeutic potential of umbilical cord stem cells was demonstrated in the treatment of bone patholo…
View article: Corneal Biomechanical Changes in Third Trimester of Pregnancy
Corneal Biomechanical Changes in Third Trimester of Pregnancy Open
Background and Objectives: There is a clear evidence that pregnancy is associated with high production of sex hormones. During the first, second and third trimester of pregnancy, blood hormones levels increase gradually. Cells with affinit…
View article: Developing Core Outcome Sets (COS) and Core Outcome Measures Sets (COMS) in Cosmetic Gynecological Interventions: Protocol for a Development and Usability Study (Preprint)
Developing Core Outcome Sets (COS) and Core Outcome Measures Sets (COMS) in Cosmetic Gynecological Interventions: Protocol for a Development and Usability Study (Preprint) Open
BACKGROUND Studies evaluating cosmetic gynecological interventions have followed variable methodology and reported a diversity of outcomes. Such variations limit the comparability of studies and the value of research-based evidence. The d…
View article: Management strategies and clinical follow-up of pregnant women with intracranial meningioma
Management strategies and clinical follow-up of pregnant women with intracranial meningioma Open
Meningiomas are common primary tumors of the central nervous system. The incidence at the age of fertility is low, although there are some hormonal mechanisms involved. Growth in size was observed during the luteal phase of the menstrual c…
View article: Sentinel Lymph Node Biopsy in Breast Cancer. Principle, Difficulties and Pitfalls
Sentinel Lymph Node Biopsy in Breast Cancer. Principle, Difficulties and Pitfalls Open
Sentinel Lymph node biopsy (SLNB) represents the standard approach in a newly diagnosed breast cancer for axillary staging in cases of clinical node negative. This represents a major prognostic factor and the biopsy of sentinel lymph node …
View article: Methods of Delivery in Pregnant Women with Lumbar Disc Herniation: A Narrative Review of General Management and Case Report
Methods of Delivery in Pregnant Women with Lumbar Disc Herniation: A Narrative Review of General Management and Case Report Open
Low back pain is a common complaint during pregnancy, affecting approximately half of pregnant women. However, true disc herniation is extremely rare, and the majority of patients heal without surgery. The purpose of this study was to prov…
View article: Diagnosticul ecografic al fibroamelor ovariene
Diagnosticul ecografic al fibroamelor ovariene Open
Ovarian fibromas are representative in the group of solid benign tumors of the ovary, accounting for 4% of all ovarian masses. Ovarian fibromas have sex cord/stromal origin and appear particularly in the fourth or fifth decade in menop…
View article: Diagnosticul adenomiozei uterine la pacientele de vârstă reproductivă
Diagnosticul adenomiozei uterine la pacientele de vârstă reproductivă Open
Uterine adenomyosis is a gynecologic condition characterized by the presence of islands of ectopic endometrial tissue inside the myometrium. This disease affects 20% of women of reproductive age, causing pelvic pain, abnormal uterine bl…