George Mitroi
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View article: Comparative Analysis of Transperineal Cognitive Fusion, Systematic, and Combined Biopsies for Prostate Cancer Detection
Comparative Analysis of Transperineal Cognitive Fusion, Systematic, and Combined Biopsies for Prostate Cancer Detection Open
Background and Objectives: Multiparametric MRI (mpMRI) has improved prostate cancer (PCa) detection, but the added value of cognitive fusion (CF) over systematic biopsy (SB) remains debated. This prospective study evaluated the diagnostic …
View article: The Diagnostic and Prognostic Value of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Urosepsis
The Diagnostic and Prognostic Value of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Urosepsis Open
Background and Objectives: The severe systemic response to urinary tract infections known as urosepsis is associated with significant morbidity and mortality rates. The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ra…
View article: Sweet Syndrome-like Dermatosis as a Precursor to Overlapping Hematologic Malignancies: A Case Report and Review.
Sweet Syndrome-like Dermatosis as a Precursor to Overlapping Hematologic Malignancies: A Case Report and Review. Open
Sweet syndrome (SS) is a rare neutrophilic dermatosis often associated with hematologic malignancies, particularly myelodysplastic syndromes (MDSs). We report a case of SS-like dermatosis in a patient with MDS who subsequently developed pe…
View article: Utility and Challenges of Imaging in Peripheral Vestibular Disorder Diagnosis: A Narrative Review
Utility and Challenges of Imaging in Peripheral Vestibular Disorder Diagnosis: A Narrative Review Open
This review focuses on the contribution of medical imaging in the diagnosis of peripheral vestibular disorders. This is a narrative review based on a focused literature search conducted using PubMed and the Cochrane Library. Imaging is not…
View article: Dermatomyositis-like Eruption Induced by Hydroxyurea—Case Report and Literature Review
Dermatomyositis-like Eruption Induced by Hydroxyurea—Case Report and Literature Review Open
Background: Hydroxyurea (HU) is a widely used chemotherapeutic agent for myeloproliferative disorders, yet its long-term use can rarely trigger a dermatomyositis-like (DM-like) eruption characterized solely by cutaneous manifestations with…
View article: Inferior Vestibular Neuritis: Diagnostic Criteria, Clinical Features, and Prognosis—A Focused Review
Inferior Vestibular Neuritis: Diagnostic Criteria, Clinical Features, and Prognosis—A Focused Review Open
Purpose: This review aims to analyze the diagnostic methods used to evaluate inferior vestibular nerve neuritis. Methods: We performed an electronic search on the PubMed database for clinical studies investigating the diagnostic techniques…
View article: Unveiling the Complexities of Hereditary Angioedema
Unveiling the Complexities of Hereditary Angioedema Open
Hereditary angioedema (HAE) is a rare and potentially life-threatening genetic disorder, constituting approximately 2% of all clinical cases of angioedema, with a global prevalence estimated between 1 in 50,000 and 1 in 150,000 individuals…
View article: Clinical Outcomes and Safety Assessment of Flexible Ureteroscopy as an Outpatient Procedure: A Retrospective Single-Center Study
Clinical Outcomes and Safety Assessment of Flexible Ureteroscopy as an Outpatient Procedure: A Retrospective Single-Center Study Open
Nephrolithiasis, or kidney stone disease, is a significant global health issue in urology, requiring effective management strategies. The management of nephrolithiasis through flexible ureteroscopy (fURS) is increasingly gaining acceptance…
View article: Off-Label Uses of Abrocitinib: Review of Emerging Therapeutic Applications beyond Atopic Dermatitis
Off-Label Uses of Abrocitinib: Review of Emerging Therapeutic Applications beyond Atopic Dermatitis Open
Abrocitinib, an oral small-molecule Janus Kinase 1 (JAK1) inhibitor, is primarily approved for treating moderate-to-severe atopic dermatitis (AD) in adults and adolescents aged 12 and older. This review examines the emerging off-label uses…
View article: Exploring the Potential of IL-4 and IL-13 Plasma Levels as Biomarkers in Atopic Dermatitis
Exploring the Potential of IL-4 and IL-13 Plasma Levels as Biomarkers in Atopic Dermatitis Open
Atopic dermatitis (AD) is a persistent inflammatory skin condition that impacts individuals of various age groups, including both children and adults. Its pathophysiology involves allergens penetrating a disrupted epidermal barrier, trigge…
View article: Simplified Diagnosis of Urosepsis by Emergency Ultrasound Combined with Clinical Scores and Biomarkers
Simplified Diagnosis of Urosepsis by Emergency Ultrasound Combined with Clinical Scores and Biomarkers Open
Background Urosepsis is a life-threatening medical condition due to a systemic infection that originates in the urinary tract. Early diagnosis and treatment of urosepsis are critical to reducing mortality rates and preventing complications…
View article: Case Series Analysis of Late-Onset Atopic Dermatitis: Unraveling Clinical Variants.
Case Series Analysis of Late-Onset Atopic Dermatitis: Unraveling Clinical Variants. Open
Atopic Dermatitis (AD), recognized as one of the most prevalent chronic inflammatory skin disorders among children, is characterized by skin barrier dysfunction and immune system abnormalities. Historically viewed as a childhood condition,…
View article: Retinal Functional Impairment in Diabetic Retinopathy
Retinal Functional Impairment in Diabetic Retinopathy Open
Background: Diabetic retinopathy (DR) is a neurodegenerative disease of the retina. The aim of our study was to analyze latency changes in a full-field electroretinogram (ERG) in patients with type 2 diabetes. Material: This prospective st…
View article: Defining the short-term and long-term skin manifestations of COVID-19: insights after more than three years of the pandemic
Defining the short-term and long-term skin manifestations of COVID-19: insights after more than three years of the pandemic Open
Apart from classified COVID-19-related skin disorders, this pandemic has been a challenge for dermatologists and a wide range of cutaneous side effects related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) treatments have…
View article: Preliminary study of some of the main intratumor stroma components in gastric carcinomas
Preliminary study of some of the main intratumor stroma components in gastric carcinomas Open
TS is in a continuous remodeling process in relation to the evolution of tumor parenchyma, tumors less differentiated proving to have an immature stroma, with newly formed collagen fibers and higher vascular density. Further studies are re…
View article: Assessment of tumor microenvironment in gastric adenocarcinoma
Assessment of tumor microenvironment in gastric adenocarcinoma Open
Gastric cancer (GC), despite the current possibilities of early diagnosis and curative treatment, remains a major public health problem, being one of the main causes of cancer, due to its detection in advanced stages. Screening programs ap…
View article: Hereditary Angioedema
Hereditary Angioedema Open
Hereditary angioedema (HAE) is a very rare and potentially life-threatening genetic disease characterized by low levels of C1-INH inhibitor esterase and involving recurrent attacks of non-pruritic angioedema that do not leave subcutaneous …
View article: Cutaneous Malignant Melanoma Metastatic to the Larynx and Trachea: A Case Report and Review of the Literature
Cutaneous Malignant Melanoma Metastatic to the Larynx and Trachea: A Case Report and Review of the Literature Open
Malignant melanoma rarely develops in mucous membranes. Statistical data show that approximately 0.6–9.3% of patients with cutaneous malignant melanoma will develop metastases in the upper aerodigestive tract mucosa, and within these metas…
View article: Transperineal Prostate Biopsy Targeted by Magnetic Resonance Imaging Cognitive Fusion
Transperineal Prostate Biopsy Targeted by Magnetic Resonance Imaging Cognitive Fusion Open
Prostate cancer is among the most frequently diagnosed cancers and a leading cause of cancer-related death in men. Currently, the most reliable and widely used imaging test for prostate cancer diagnosis is multiparametric pelvic magnetic r…
View article: Preoperative Immunocite-Derived Ratios Predict Surgical Complications Better when Artificial Neural Networks Are Used for Analysis—A Pilot Comparative Study
Preoperative Immunocite-Derived Ratios Predict Surgical Complications Better when Artificial Neural Networks Are Used for Analysis—A Pilot Comparative Study Open
We aimed to comparatively assess the prognostic preoperative value of the main peripheral blood components and their ratios—the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (L…
View article: Ventral Hernia Repair and Drainage - A Prospective, Observational, and Comparative Study of Outcomes
Ventral Hernia Repair and Drainage - A Prospective, Observational, and Comparative Study of Outcomes Open
Background: While ventral hernia repair is a frequent surgical intervention, the possibility of complications remains present. The use of drains to mitigate complications is a topic of debate, with conflicting evidence. This study aimed to…
View article: The histopathological features and their prognostic impact in the postoperative follow-up of colorectal cancer patients
The histopathological features and their prognostic impact in the postoperative follow-up of colorectal cancer patients Open
The validation of histological prognostic markers in colorectal cancer not only for survival parameters but also for early postoperative outcomes is of paramount importance. The aim of our study was to search for the tumor histopathologica…
View article: Atopic Dermatitis with Multiple Comorbidities Treated with Dupilumab. A Case Report and Review of the Literature Regarding the Safety of Dupilumab
Atopic Dermatitis with Multiple Comorbidities Treated with Dupilumab. A Case Report and Review of the Literature Regarding the Safety of Dupilumab Open
Dupilumab is the only available biological treatment for moderate-to-severe atopic dermatitis (AD). Even so, limited clinical data regarding its safety profile are available. Interactions with other drugs and the adverse effects of Dupilum…
View article: Histological and immunohistochemical study of brain damage in traumatic brain injuries in children, depending on the survival period
Histological and immunohistochemical study of brain damage in traumatic brain injuries in children, depending on the survival period Open
Numerous studies showed that, at present, traumatic brain injury (TBI) is one of the main causes of death in young adults, but also a main cause of disabilities at all ages. For these reasons, TBI are continuously investigated. In our stud…
View article: The role of cell adhesion molecules in the progression of bladder urothelial carcinomas
The role of cell adhesion molecules in the progression of bladder urothelial carcinomas Open
Alteration of the intercellular adhesion system plays an essential role in the initiation and progression of bladder carcinomas. We followed the immunoexpression of adhesion molecules, E-cadherin, β-catenin and Claudin-1, in relation to th…
View article: Clinical and pathological considerations in lumbar herniated disc associated with inflammatory lesions
Clinical and pathological considerations in lumbar herniated disc associated with inflammatory lesions Open
Lumbar herniated disc is the most frequent cause for lumbar pain. It is caused by degenerative, macroscopic and microscopic changes of the intervertebral discs. It is a chronic disease, with periods of exacerbation and remission under drug…
View article: Histopathological and immunohistochemical study of periodontal changes in chronic smokers
Histopathological and immunohistochemical study of periodontal changes in chronic smokers Open
Periodontal disease is a chronic inflammatory, multifactorial condition, that, in the absence of an early and adequate treatment, may lead to a progressive damaging of the alveolar tissues that support the teeth (periodontal ligament, ceme…
View article: Pathological and immunohistochemical study of colon cancer. Evaluation of markers for colon cancer stem cells
Pathological and immunohistochemical study of colon cancer. Evaluation of markers for colon cancer stem cells Open
Colorectal cancer is a major public health problem worldwide with increasing morbidity and mortality. Numerous exogenous and endogenous factors are involved in colorectal carcinogenesis: age, sex, diet, smoking, alcohol consumption, exposu…
View article: Nasal Microbiology from Patients with Chronic Rhinosinusitis
Nasal Microbiology from Patients with Chronic Rhinosinusitis Open
The purpose of this study is to establish if the germs that were identified in the bacteriological examination of nasal secretions of patients with CRS without nasal polyposis and patients with CRS with nasal polyposis are different. Study…