George T. Kannarkat
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View article: Alpha-Synuclein Neurobiology in Parkinson’s Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives
Alpha-Synuclein Neurobiology in Parkinson’s Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives Open
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the presence of intracellular α-synuclein (αSyn) aggregates known as Lewy bodies (LB). …
View article: Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies
Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies Open
Objective Aggregation of misfolded α‐synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB) disease. Although evidence exists for a…
View article: Measurement of α-synuclein as protein cargo in plasma extracellular vesicles
Measurement of α-synuclein as protein cargo in plasma extracellular vesicles Open
Extracellular vesicles (EVs) are released by all cells and hold great promise as a class of biomarkers. This promise has led to increased interest in measuring EV proteins from both total EVs as well as brain-derived EVs in plasma. However…
View article: Alpha-Synuclein Conformations in Plasma Distinguish Parkinson’s Disease from Dementia with Lewy Bodies
Alpha-Synuclein Conformations in Plasma Distinguish Parkinson’s Disease from Dementia with Lewy Bodies Open
Aggregation of misfolded alpha-synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Evidence exists for aSyn “strains” – conformat…
View article: α-Synuclein Conformations in Plasma Distinguish Parkinson’s Disease from Dementia with Lewy Bodies
α-Synuclein Conformations in Plasma Distinguish Parkinson’s Disease from Dementia with Lewy Bodies Open
Spread and aggregation of misfolded α-synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). While evidence exists for multiple aSyn…
View article: Assessment of extracellular vesicle protein cargo as neurodegenerative disease biomarkers
Assessment of extracellular vesicle protein cargo as neurodegenerative disease biomarkers Open
Extracellular vesicles (EVs) are released by all cells and hold great promise as a class of biomarkers. As EVs represent a way of capturing molecular information about the proteins inside of cells, EVs from biofluids could be used to bette…
View article: Early and Accurate Diagnosis of Parkinson Disease May Be Rooted in Seed Amplification Assays
Early and Accurate Diagnosis of Parkinson Disease May Be Rooted in Seed Amplification Assays Open
Journal Article Early and Accurate Diagnosis of Parkinson Disease May Be Rooted in Seed Amplification Assays Get access Thomas F Tropea, Thomas F Tropea Department of Neurology, Perelman School of Medicine at the University of Pennsylvania…
View article: Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system
Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system Open
Introduction Progranulin (PGRN) is a secreted glycoprotein, the expression of which is linked to several neurodegenerative diseases. Although its specific function is still unclear, several studies have linked it with lysosomal functions a…
View article: Effect of Exercise and Rehabilitation Therapy on Risk of Hospitalization in Parkinson's Disease
Effect of Exercise and Rehabilitation Therapy on Risk of Hospitalization in Parkinson's Disease Open
Background Exercise and physical therapy (PT) can improve motor function and quality of life in individuals with Parkinson's disease (PD), but their role in hospitalization avoidance is not well‐studied. Objectives To determine the longitu…
View article: Perineural spread of melanoma to the central nervous system
Perineural spread of melanoma to the central nervous system Open
Leptomeningeal carcinomatosis is an increasingly recognized phenomenon for metastatic spread of a wide variety of carcinomas to the Central Nervous System (CNS). We report a case of a 79 year-old man with perineural spread of locally invas…
View article: Risk of Drug-induced Movement Disorders with Newer Antipsychotic Agents
Risk of Drug-induced Movement Disorders with Newer Antipsychotic Agents Open
Several novel antipsychotics, particularly lumateperone and pimavanserin, show promise in being able to treat psychosis while reducing the risk of DIMD. Long-acting paliperidone may reduce risk of DIMD while other long-acting injectable fo…
View article: Additional file 1 of Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology
Additional file 1 of Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology Open
Additional file 1. Characteristics of subjects from whom colon biopsies were collected for evaluation of inflammatory markers.
View article: Sternocleidomastoid muscle hypertrophy in cervical dystonia
Sternocleidomastoid muscle hypertrophy in cervical dystonia Open
During a hospitalization for sepsis in the setting of a urinary tract infection, a 69-year-old man with idiopathic Parkinson disease (PD) developed severe, sudden-onset left-sided neck pain an hour after receiving quetiapine to treat hospi…
View article: O2‐11‐03: PROGRANULIN LOSS DYSREGULATES SPLENIC AND PERIPHERAL BLOOD IMMUNE CELL POPULATIONS AND MAY CONTRIBUTE TO NEUROINFLAMMATION AND NEURODEGENERATION IN FRONTOTEMPORAL DEMENTIA
O2‐11‐03: PROGRANULIN LOSS DYSREGULATES SPLENIC AND PERIPHERAL BLOOD IMMUNE CELL POPULATIONS AND MAY CONTRIBUTE TO NEUROINFLAMMATION AND NEURODEGENERATION IN FRONTOTEMPORAL DEMENTIA Open
Mutations in the progranulin gene (GRN) reduce circulating levels of progranulin (PGRN) and granulins (GRNs) and cause frontotemporal degeneration (FTD). PGRN is neuroprotective and decreases amyloid β (Aβ) deposition in APP mice. Strategi…
View article: Additional file 9: of Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease
Additional file 9: of Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease Open
Linear discriminant analysis reveals sensitivity and selectivity of analytes in discriminating between HC and PD. Serum and CSF levels of IL-6 (a), serum IL-6 (b). Serum and CSF IL-8, TNF, NGAL, and IFNγ, and CSF α-synuclein, Aβ40 and Aβ42…
View article: Additional file 8: of Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease
Additional file 8: of Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease Open
CSF IFNγ and serum IL-8 positively correlated with UPDRS components at baseline in PD subjects. (PDF 563 kb)
View article: RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis
RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis Open
These data demonstrate a critical role for RGS10 in mediating autoimmune disease through regulation of T lymphocyte function. This is the first study ever conducted to elucidate the function of RGS10 in effector lymphocytes in the context …
View article: Pesticide-induced Immunotoxicity May Underlie Synergistic Gene-environment Interactions that Increase Parkinson's Disease Risk for High-risk Genotype Individuals at rs3129882 in the HLA-DRA Gene
Pesticide-induced Immunotoxicity May Underlie Synergistic Gene-environment Interactions that Increase Parkinson's Disease Risk for High-risk Genotype Individuals at rs3129882 in the HLA-DRA Gene Open
The Human Leukocyte Antigen (HLA) gene loci contains immune system-related genes involved in antigen presentation and in recent years, certain genetic variants in HLA genes have been associated with increased risk for late-onset Parkinson’…