Georgene W. Hergenroeder
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View article: SAHRANG: Subarachnoid Hemorrhage Recovery and Galantamine: A Pilot Multicenter Randomized Placebo-Controlled Trial
SAHRANG: Subarachnoid Hemorrhage Recovery and Galantamine: A Pilot Multicenter Randomized Placebo-Controlled Trial Open
Background Subarachnoid hemorrhage (SAH) causes life-long neurologic dysfunction. Peripheral inflammatory processes as a reaction to brain injury have been shown to worsen outcomes after SAH. Galantamine has been shown to reduce proinflamm…
View article: SAHRANG: Subarachnoid Hemorrhage Recovery and Galantamine - A pilot multicenter randomized placebo-controlled trial
SAHRANG: Subarachnoid Hemorrhage Recovery and Galantamine - A pilot multicenter randomized placebo-controlled trial Open
Background Subarachnoid hemorrhage (SAH) causes life-long neurologic dysfunctions. Peripheral inflammatory processes as a reaction to brain injury has been shown to worsen outcomes after SAH. Galantamine has been shown to reduce proinflamm…
View article: Case Report: Rare intraventricular H3 K27-altered diffuse midline glioma in an adult
Case Report: Rare intraventricular H3 K27-altered diffuse midline glioma in an adult Open
H3 K27-Altered Diffuse Midline Gliomas are commonly found in children and adolescents in midline locations such as the thalamus, brain stem, and spinal cord. It is rare for these tumors to affect adults and to occur in locations like the l…
View article: Building community through data: the value of a researcher driven open science ecosystem
Building community through data: the value of a researcher driven open science ecosystem Open
View article: Building Community Through Data: The value of a Researcher Driven Open Science Ecosystem
Building Community Through Data: The value of a Researcher Driven Open Science Ecosystem Open
Exponential scientific data growth presents challenges and opportunities for addressing complex public health issues like the opioid epidemic and chronic pain management. Despite the vast amount of research conducted globally, many dataset…
View article: Administration of anti-GFAP antibodies increases CGRP expression and increases pain hypersensitivity in spinal cord injured animals
Administration of anti-GFAP antibodies increases CGRP expression and increases pain hypersensitivity in spinal cord injured animals Open
Background: Spinal cord injury (SCI) results in a multitude of cellular and pathological changes including neuronal loss, axonal damage, gliosis, and loss of motor and sensory function. In 40%–70% of patients, SCI can also trigger the deve…
View article: Lysophospholipids Are Associated With Outcomes in Hospitalized Patients With Mild Traumatic Brain Injury
Lysophospholipids Are Associated With Outcomes in Hospitalized Patients With Mild Traumatic Brain Injury Open
Mild traumatic brain injury (mTBI) accounts for 70-90% of all TBI cases. Lipid metabolites have important roles in plasma membrane biogenesis, function, and cell signaling. As TBI can compromise plasma membrane integrity and alter brain ce…
View article: Systemic inflammatory markers of persistent cerebral edema after aneurysmal subarachnoid hemorrhage
Systemic inflammatory markers of persistent cerebral edema after aneurysmal subarachnoid hemorrhage Open
Background Cerebral edema (CE) at admission is a surrogate marker of ‘early brain injury’ (EBI) after subarachnoid hemorrhage (SAH). Only recently has the focus on the changes in CE after SAH such as delayed resolution or newly developed C…
View article: Epigenetic Modifications and Their Potential Contribution to Traumatic Brain Injury Pathobiology and Outcome
Epigenetic Modifications and Their Potential Contribution to Traumatic Brain Injury Pathobiology and Outcome Open
Epigenetic information is not permanently encoded in the DNA sequence, but rather consists of reversible, heritable modifications that regulate the gene expression profile of a cell. Epigenetic modifications can result in cellular changes …
View article: Postmortem Study of Organ-Specific Toxicity in Glioblastoma Patients Treated with a Combination of Temozolomide, Irinotecan and Bevacizumab
Postmortem Study of Organ-Specific Toxicity in Glioblastoma Patients Treated with a Combination of Temozolomide, Irinotecan and Bevacizumab Open
Purpose Systemic monotherapy with temozolomide (TMZ) or bevacizumab (BEV); two-drug combinations, such as Irinotecan (IRI) and BEV, TMZ and BEV and a three-drug combination with TMZ, IRI and BEV (TIB) have been used in treating patients wi…
View article: 25: Seroprevalence and clinical characteristics of SARS-CoV-2 infection in children and adolescents with cystic fibrosis
25: Seroprevalence and clinical characteristics of SARS-CoV-2 infection in children and adolescents with cystic fibrosis Open
View article: Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial
Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial Open
View article: Machine Learning to Predict Delayed Cerebral Ischemia and Outcomes in Subarachnoid Hemorrhage
Machine Learning to Predict Delayed Cerebral Ischemia and Outcomes in Subarachnoid Hemorrhage Open
ML models significantly outperform SMs in predicting DCI and functional outcomes and has the potential to improve SAH management.
View article: Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities Open
Pain medication plays an important role in the treatment of acute and chronic pain conditions, but some drugs, opioids in particular, have been overprescribed or prescribed without adequate safeguards, leading to an alarming rise in medica…
View article: Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage
Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage Open
View article: The institutional impact after enacting student solutions to decrease barriers in reporting unprofessional behaviors
The institutional impact after enacting student solutions to decrease barriers in reporting unprofessional behaviors Open
This article was migrated. The article was marked as recommended. A two-year study was conducted to evaluate medical student perceptions on professionalism, including barriers to reporting misconduct and solutions to address barriers. Inst…
View article: Systematic model of peripheral inflammation after subarachnoid hemorrhage
Systematic model of peripheral inflammation after subarachnoid hemorrhage Open
Combining reductionist and systematic techniques may lead to a better understanding of the underlying complexities of the inflammatory reaction after aSAH.
View article: Human neural progenitors derived from integration-free iPSCs for SCI therapy
Human neural progenitors derived from integration-free iPSCs for SCI therapy Open
View article: CIRCULATING AUTOANTIBODIES IN HUMAN TRAUMATIC SPINAL CORD INJURY SUBJECTS AND THEIR RELATIONSHIP TO THE DEVELOPMENT OF NEUROPATHIC PAIN
CIRCULATING AUTOANTIBODIES IN HUMAN TRAUMATIC SPINAL CORD INJURY SUBJECTS AND THEIR RELATIONSHIP TO THE DEVELOPMENT OF NEUROPATHIC PAIN Open
Background: Approximately 17,500 spinal cord injuries (SCI) occur yearly in the U.S. causing considerable morbidity and mortality. Neuropathic pain (NP) ensues in 40-70% of SCI. An autoimmune response resulting from disruption of the blood…
View article: <i>THSD1</i>(Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage
<i>THSD1</i>(Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage Open
Background and Purpose— A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage. This study seeks to define a specific gene whose mutation leads to disease. Methods— More than 500 IA probands and 100 affecte…
View article: Traumatic Brain Injury Alters Methionine Metabolism: Implications for Pathophysiology
Traumatic Brain Injury Alters Methionine Metabolism: Implications for Pathophysiology Open
Methionine is an essential proteinogenic amino acid that is obtained from the diet. In addition to its requirement for protein biosynthesis, methionine is metabolized to generate metabolites that play key roles in a number of cellular func…
View article: Identification of autoantibodies to glial fibrillary acidic protein in spinal cord injury patients
Identification of autoantibodies to glial fibrillary acidic protein in spinal cord injury patients Open
Traumatic spinal cord injury (SCI) is a devastating injury causing significant morbidity and mortality. Experimental studies have demonstrated that SCI induced cellular damage and disruption of the blood-spinal cord barrier can initiate an…