Georges Tarlet
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View article: Association between cardiac radiation dose and coronary artery calcification progression in breast cancer patients after radiotherapy: the modifying role of concomitant systemic inflammation (BACCARAT study)
Association between cardiac radiation dose and coronary artery calcification progression in breast cancer patients after radiotherapy: the modifying role of concomitant systemic inflammation (BACCARAT study) Open
Radiation-induced cardiotoxicity remains a significant concern in breast cancer (BC) patients treated with radiotherapy (RT), with both cardiac radiation exposure and systemic inflammation emerging as key contributors to early cardiovascul…
View article: Inflammation in Focus
Inflammation in Focus Open
View article: Non-homogenous intratumor ionizing radiation doses synergize with PD1 and CXCR2 blockade
Non-homogenous intratumor ionizing radiation doses synergize with PD1 and CXCR2 blockade Open
View article: Evidence of Alveolar Macrophage Metabolic Shift Following Stereotactic Body Radiation Therapy -Induced Lung Fibrosis in Mice
Evidence of Alveolar Macrophage Metabolic Shift Following Stereotactic Body Radiation Therapy -Induced Lung Fibrosis in Mice Open
Our study brings new possible clues to the understanding of macrophage implications in radiation-induced lung damage, representing an interesting area for exploration in future studies.
View article: Comparing cellular response to two radiation treatments based on key features visualization
Comparing cellular response to two radiation treatments based on key features visualization Open
Motivation In modern treatment by radiotherapy, different irradiation modalities can be used, potentially producing different amounts of adverse effects. The differences between these modalities are often studied via two-sample time course…
View article: A role for endothelial alpha-mannosidase MAN1C1 in radiation-induced immune cell recruitment
A role for endothelial alpha-mannosidase MAN1C1 in radiation-induced immune cell recruitment Open
Radiation therapy damages tumors and normal tissues, probably in part through the recruitment of immune cells. Endothelial high-mannose N-glycans are, in particular, involved in monocyte-endothelium interactions. Trimmed by the class I α-m…
View article: Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation
Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation Open
View article: Preclinical Model of Stereotactic Ablative Lung Irradiation Using Arc Delivery in the Mouse: Is Fractionation Worthwhile?
Preclinical Model of Stereotactic Ablative Lung Irradiation Using Arc Delivery in the Mouse: Is Fractionation Worthwhile? Open
Lung stereotactic body radiation therapy is characterized by a reduction in target volumes and the use of severely hypofractionated schedules. Preclinical modeling became possible thanks to rodent-dedicated irradiation devices allowing acc…
View article: Deciphering the Dynamic Molecular Program of Radiation-Induced Endothelial Senescence
Deciphering the Dynamic Molecular Program of Radiation-Induced Endothelial Senescence Open
Our work provides crucial information on the dynamics of the radiation-induced premature senescence process, the effect of the radiation dose, as well as the molecular program involved in the heterogeneous senescent status of ECs.
View article: Variation of 4 MV X-ray dose rate in fractionated irradiation strongly impacts biological endothelial cell response <i>in vitro</i>
Variation of 4 MV X-ray dose rate in fractionated irradiation strongly impacts biological endothelial cell response <i>in vitro</i> Open
These results strengthen the interest of multiparametric analysis approaches in providing an accurate evaluation of the outcomes of irradiated cells in support of clonogenic assays, especially when such assays are not feasible.
View article: Variation of 4 MV X-ray dose rate in fractionated irradiation strongly impacts biological endothelial cell response <i>in vitro</i>
Variation of 4 MV X-ray dose rate in fractionated irradiation strongly impacts biological endothelial cell response <i>in vitro</i> Open
Even though X-ray beams are widely used in medical diagnosis or radiotherapy, the comparisons of their dose rates are scarce. We have recently demonstrated in vitro (clonogenic assay, cell viability, cell cycle, senescence) and in vivo (we…
View article: Cellular therapy treatment of chronic radiation cystitis in rats
Cellular therapy treatment of chronic radiation cystitis in rats Open
View article: Variation of 4 MV X-ray dose rate strongly impacts biological response both in vitro and in vivo
Variation of 4 MV X-ray dose rate strongly impacts biological response both in vitro and in vivo Open
View article: Preclinical Model of Stereotactic Ablative Lung Irradiation Using Arc Delivery in the Mouse: Effect of Beam Size Changes and Dose Effect at Constant Collimation
Preclinical Model of Stereotactic Ablative Lung Irradiation Using Arc Delivery in the Mouse: Effect of Beam Size Changes and Dose Effect at Constant Collimation Open
Arc therapy allows long-term studies and dose escalation without lethality. In our dose-delivery conditions, dose-effect studies revealed that 3 × 3 mm2 beam collimation to a minimum single dose of 60 Gy enables preclinical mode…
View article: PO-1065 Multiparametric radiobiological parameters implementation to predict radiation-induced side effects
PO-1065 Multiparametric radiobiological parameters implementation to predict radiation-induced side effects Open
View article: Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys
Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys Open
Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney. Methods: M…
View article: Temporal clustering analysis of endothelial cell gene expression following exposure to a conventional radiotherapy dose fraction using Gaussian process clustering
Temporal clustering analysis of endothelial cell gene expression following exposure to a conventional radiotherapy dose fraction using Gaussian process clustering Open
The vascular endothelium is considered as a key cell compartment for the response to ionizing radiation of normal tissues and tumors, and as a promising target to improve the differential effect of radiotherapy in the future. Following rad…
View article: HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis
HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis Open
View article: Radiation-induced changes in the glycome of endothelial cells with functional consequences
Radiation-induced changes in the glycome of endothelial cells with functional consequences Open
View article: Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice
Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice Open
The current study evaluated the role of Hey2 transcription factor in radiation-induced endothelial-to-mesenchymal transition (EndoMT) and its impact on radiation-induced tissue damage in mice. Phenotypic modifications of irradiated, Hey2 s…
View article: OC-0031: Global changes in the glycosylation of irradiated endothelial cells with functional consequences
OC-0031: Global changes in the glycosylation of irradiated endothelial cells with functional consequences Open
View article: In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury
In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury Open
The pathophysiological mechanism involved in side effects of radiation therapy and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation…