Georges Tocco
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View article: Both Rejection and Tolerance of Allografts Can Occur in the Absence of Secondary Lymphoid Tissues
Both Rejection and Tolerance of Allografts Can Occur in the Absence of Secondary Lymphoid Tissues Open
In this study, we showed that aly/aly mice, which are devoid of lymph nodes and Peyer’s patches, acutely rejected fully allogeneic skin and heart grafts. They mounted potent inflammatory direct alloresponses but failed to develop indirect …
View article: Primary Vascularization of Allografts Governs Their Immunogenicity and Susceptibility to Tolerogenesis
Primary Vascularization of Allografts Governs Their Immunogenicity and Susceptibility to Tolerogenesis Open
We investigated the influence of allograft primary vascularization on alloimmunity, rejection, and tolerance in mice. First, we showed that fully allogeneic primarily vascularized and conventional skin transplants were rejected at the same…
View article: The road to transplant tolerance is paved with good dendritic cells
The road to transplant tolerance is paved with good dendritic cells Open
After transplantation, recipient T cells can recognize donor antigens either by interacting with MHC class II on donor bone marrow‐derived cells (direct allorecognition), or by recognizing allogeneic peptides bound to self‐MHC class II mol…
View article: Differential Effects of Denileukin Diftitox IL-2 Immunotoxin on NK and Regulatory T Cells in Nonhuman Primates
Differential Effects of Denileukin Diftitox IL-2 Immunotoxin on NK and Regulatory T Cells in Nonhuman Primates Open
Denileukin diftitox (DD), a fusion protein comprising IL-2 and diphtheria toxin, was initially expected to enhance antitumor immunity by selectively eliminating regulatory T cells (Tregs) displaying the high-affinity IL-2R (α-β-γ trimers).…
View article: Innate Immunity and Resistance to Tolerogenesis in Allotransplantation
Innate Immunity and Resistance to Tolerogenesis in Allotransplantation Open
The development of immunosuppressive drugs to control adaptive immune responses has led to the success of transplantation as a therapy for end-stage organ failure. However, these agents are largely ineffective in suppressing components of …
View article: Contributions of Direct and Indirect Alloresponses to Chronic Rejection of Kidney Allografts in Nonhuman Primates
Contributions of Direct and Indirect Alloresponses to Chronic Rejection of Kidney Allografts in Nonhuman Primates Open
The relative contribution of direct and indirect allorecognition pathways to chronic rejection of allogeneic organ transplants in primates remains unclear. In this study, we evaluated T and B cell alloresponses in cynomolgus monkeys that h…
View article: Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus
Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus Open
The location and nature of the changes underlying long-term potentiation (LTP) remain controversial issues. In this study, we tested the possibility that changes in binding properties of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propi…
View article: A negative correlation between the induction of long-term potentiation and activation of immediate early genes
A negative correlation between the induction of long-term potentiation and activation of immediate early genes Open
In the present study we examined the relationship between the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats and activation of immediate early genes (IEGs; c-fos and zif/268) using several different hig…
View article: Emergence neophobia correlates with hippocampal and cortical glutamate receptor binding in rats
Emergence neophobia correlates with hippocampal and cortical glutamate receptor binding in rats Open
Previous work from our laboratory indicated that emergence neophobia is highly correlated with perforant path long-term potentiation (LTP) in rats. In the present study, we examined the relationship between hippocampal and cortical alpha-a…
View article: T-cell response to p53 tumor-associated antigen in patients with colorectal carcinoma
T-cell response to p53 tumor-associated antigen in patients with colorectal carcinoma Open
Despite the radical surgical resection performed in patients with colorectal carcinoma, there is a high rate of tumor recurrence. Over an observation period of 3 years, 18% of the patients in our collective suffered a tumor relapse with lo…
View article: A Salen-Manganese Catalytic Free Radical Scavenger Inhibits Type 1 Diabetes and Islet Allograft Rejection
A Salen-Manganese Catalytic Free Radical Scavenger Inhibits Type 1 Diabetes and Islet Allograft Rejection Open
Reactive oxygen species, such as superoxide, and nitrogen oxides, such as peroxynitrite, are thought to contribute to β-cell destruction during the disease process that leads to type 1 diabetes. EUK-8 is a member of a new class of syntheti…
View article: EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology Open
The present study tested the effects of EUK-134, a synthetic superoxide dismutase/catalase mimetic, on several indices of oxidative stress and neuropathology produced in the rat limbic system as a result of seizure activity elicited by sys…
View article: “Action-at-a-Distance” Mutagenesis
“Action-at-a-Distance” Mutagenesis Open
8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG), a common oxidative DNA lesion, favors a syn-conformation in DNA, enabling formation of stable 8-oxo-dG.A base mispairs resulting in G.C --> T.A transversion mutations. When human DNA polymera…
View article: High‐ and Low‐Affinity α‐[<sup>3</sup>H]Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid ([<sup>3</sup>H]AMPA) Binding Sites Represent Immature and Mature Forms of AMPA Receptors and Are Composed of Differentially Glycosylated Subunits
High‐ and Low‐Affinity α‐[<sup>3</sup>H]Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid ([<sup>3</sup>H]AMPA) Binding Sites Represent Immature and Mature Forms of AMPA Receptors and Are Composed of Differentially Glycosylated Subunits Open
Quantitative α‐[ 3 H]amino‐3‐hydroxy‐5‐methyl‐isoxazole‐4‐propionic acid ([ 3 H]AMPA) binding autoradiography was performed on frozen‐thawed sections from rat brain after preincubation at 0 or 35°C for 1 h. Preincubation at 35°C instead of…
View article: KID-1, a Protein Kinase Induced by Depolarization in Brain
KID-1, a Protein Kinase Induced by Depolarization in Brain Open
Membrane depolarization leads to changes in gene expression that modulate neuronal plasticity. Using representational difference analysis, we have identified a previously undiscovered cDNA, KID-1 (kinase induced by depolarization), that is…
View article: DNA Replication and Postreplication Mismatch Repair in Cell-Free Extracts from Cultured Human Neuroblastoma and Fibroblast Cells
DNA Replication and Postreplication Mismatch Repair in Cell-Free Extracts from Cultured Human Neuroblastoma and Fibroblast Cells Open
DNA synthesis and postreplication mismatch repair were measured in vitro using cell-free extracts from cultured human SY5Y neuroblastoma and WI38 fibroblast cells in different growth states. All extracts, including differentiated SY5Y and …
View article: Glycine-induced long-term potentiation is associated with structural and functional modifications of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid receptors
Glycine-induced long-term potentiation is associated with structural and functional modifications of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid receptors Open
Global long-term potentiation (LTP) was induced in organotypic hippocampal slice cultures by a brief application of 10 mM glycine. Glycine-induced LTP was occluded by previous theta burst stimulation-induced potentiation, indicating that b…
View article: Abasic Translesion Synthesis by DNA Polymerase β Violates the “A-rule”
Abasic Translesion Synthesis by DNA Polymerase β Violates the “A-rule” Open
The "A-rule" reflects the preferred incorporation of dAMP opposite abasic lesions in Escherichia coli in vivo. DNA polymerases (pol) from procaryotic and eucaryotic organisms incorporate nucleotides opposite abasic lesions in accordance wi…
View article: p53 induction is associated with neuronal damage in the central nervous system.
p53 induction is associated with neuronal damage in the central nervous system. Open
The p53 tumor-suppressor gene encodes a growth-regulatory protein that has been implicated in programmed cell death. To investigate the possible role of p53 in neuronal death, we studied p53 expression associated with excitotoxicity in the…
View article: Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo.
Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo. Open
Several lines of evidence indicate that LTP in the hippocampus is associated with a change in the properties of postsynaptic glutamate receptors. In the present study, we used quantitative autoradiography to examine the binding properties …
View article: Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo.
Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo. Open
Several lines of evidence indicate that LTP in the hippocampus is associated with a change in the properties of postsynaptic glutamate receptors. In the present study, we used quantitative autoradiography to examine the binding properties …