Georgia Dermentzaki
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View article: Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data
Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data Open
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological disease…
View article: Learning good therapeutic targets in ALS, neurodegeneration, using observational studies
Learning good therapeutic targets in ALS, neurodegeneration, using observational studies Open
Analysis of real-world data (RWD) is attractive for its applicability to real-world scenarios but RWD is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in…
View article: Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons
Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons Open
Aging is a major risk factor in amyotrophic lateral sclerosis (ALS) and other adult-onset neurodegenerative disorders. Whereas young neurons are capable of buffering disease-causing stresses, mature neurons lose this ability and degenerate…
View article: Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration
Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration Open
Motor neuron (MN) demise is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Post-transcriptional gene regulation can control RNA's fate, and defects in RNA processing are critical determinan…
View article: Depletion of <i>Mettl3</i> in Cholinergic Neurons Causes Adult-Onset Neuromuscular Degeneration
Depletion of <i>Mettl3</i> in Cholinergic Neurons Causes Adult-Onset Neuromuscular Degeneration Open
View article: Retromer dysfunction in amyotrophic lateral sclerosis
Retromer dysfunction in amyotrophic lateral sclerosis Open
Retromer is a heteropentameric complex that plays a specialized role in endosomal protein sorting and trafficking. Here, we report a reduction in the retromer proteins—vacuolar protein sorting 35 (VPS35), VPS26A, and VPS29—in patients with…
View article: Sumoylation regulates the assembly and activity of the SMN complex
Sumoylation regulates the assembly and activity of the SMN complex Open
View article: Correction: Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
Correction: Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells Open
[This corrects the article DOI: 10.1371/journal.pone.0060674.].
View article: New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System
New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System Open
RNA modifications termed epitranscriptomics represent an additional layer of gene regulation similar to epigenetic mechanisms operating on DNA. The dynamic nature and the increasing number of RNA modifications offer new opportunities for a…
View article: Deletion of<i>Ripk3</i>Prevents Motor Neuron Death<i>In Vitro</i>but not<i>In Vivo</i>
Deletion of<i>Ripk3</i>Prevents Motor Neuron Death<i>In Vitro</i>but not<i>In Vivo</i> Open
Increasing evidence suggests that necroptosis, a form of programmed cell death (PCD), contributes to neurodegeneration in several disorders, including ALS. Supporting this view, investigations in both in vitro and in vivo models of ALS hav…
View article: Complex Effects of the ZSCAN21 Transcription Factor on Transcriptional Regulation of α-Synuclein in Primary Neuronal Cultures and in Vivo
Complex Effects of the ZSCAN21 Transcription Factor on Transcriptional Regulation of α-Synuclein in Primary Neuronal Cultures and in Vivo Open
View article: LC3 II levels slightly increase following GCase inhibition in differentiated SH-SY5Y cells.
LC3 II levels slightly increase following GCase inhibition in differentiated SH-SY5Y cells. Open
(A–B) Differentiated SH-SY5Y cells were exposed to increasing doses of CBE (50, 100, 200 µΜ) for 72 h and 7 days respectively. Untreated cells served as control (ctl). Cells were lysed, separated with SDS-PAGE and immunoblotted with the LC…
View article: Μελέτη της μεταγραφικής ρύθμισης της α-συνουκλεϊνης
Μελέτη της μεταγραφικής ρύθμισης της α-συνουκλεϊνης Open
α-synuclein is a small presynaptic neuronal protein, encoded by the SNCA gene, that is implicated genetically and neuropathologically in Parkinson’s disease (PD). A large body of evidence has established that PD pathogenesis is closely lin…