Georgia Pennarossa
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View article: Microplastic exposure induces epithelial barrier alterations and increases collagen deposition in a 3D human endometrial model in vitro
Microplastic exposure induces epithelial barrier alterations and increases collagen deposition in a 3D human endometrial model in vitro Open
View article: Generation of bovine decellularized testicular bio-scaffolds as a 3D platform for testis bioengineering
Generation of bovine decellularized testicular bio-scaffolds as a 3D platform for testis bioengineering Open
Accelerating the genetic selection to obtain animals more resilient to climate changes, and with a lower environmental impact, would greatly benefit by a substantial shortening of the generation interval. One way to achieve this goal is to…
View article: Use of Decellularized Bio-Scaffolds for the Generation of a Porcine Artificial Intestine
Use of Decellularized Bio-Scaffolds for the Generation of a Porcine Artificial Intestine Open
In recent years, great interest has been focused on the development of highly reproducible 3D in vitro models that are able to mimic the physiological architecture and functionality of native tissues. To date, a wide range of techniques ha…
View article: Editorial Expression of Concern: Cell Lines Derived from Human Parthenogenetic Embryos Can Display Aberrant Centriole Distribution and Altered Expression Levels of Mitotic Spindle Check-point Transcripts
Editorial Expression of Concern: Cell Lines Derived from Human Parthenogenetic Embryos Can Display Aberrant Centriole Distribution and Altered Expression Levels of Mitotic Spindle Check-point Transcripts Open
View article: Bioengineering-tissue strategies to model mammalian implantation in vitro
Bioengineering-tissue strategies to model mammalian implantation in vitro Open
During mammalian implantation, complex and well-orchestrated interactions between the trophectoderm of implanting blastocysts and the maternal endometrium lead to a successful pregnancy. On the other hand, alteration in endometrium-blastoc…
View article: Generation of Porcine and Rainbow Trout 3D Intestinal Models and Their Use to Investigate Astaxanthin Effects In Vitro
Generation of Porcine and Rainbow Trout 3D Intestinal Models and Their Use to Investigate Astaxanthin Effects In Vitro Open
Astaxanthin (AST) is a natural compound derived from shellfish, microorganisms, and algae, with several healthy properties. For this reason, it is widely used in the diet of humans and animals, such as pigs, broilers, and fish, where its a…
View article: Therapeutic Potential of Bovine Milk-Derived Extracellular Vesicles
Therapeutic Potential of Bovine Milk-Derived Extracellular Vesicles Open
Milk is a fundamental component of the human diet, owing to its substantial nutritional content. In addition, milk contains nanoparticles called extracellular vesicles (EVs), which have indicated their potential beneficial roles such as ce…
View article: Generation of Artificial Blastoids Combining miR-200-Mediated Reprogramming and Mechanical Cues
Generation of Artificial Blastoids Combining miR-200-Mediated Reprogramming and Mechanical Cues Open
In vitro-generated blastocyst-like structures are of great importance since they recapitulate specific features or processes of early embryogenesis, thus avoiding ethical concerns as well as increasing scalability and accessibility compare…
View article: Sperm fertilizing ability in vitro influences bovine blastocyst miRNA content
Sperm fertilizing ability in vitro influences bovine blastocyst miRNA content Open
MicroRNAs (miRNAs) are small highly conserved non-coding RNA molecules that orchestrate a wide range of biological processes through post-transcriptional regulation of gene expression. During development, miRNAs play a key role in driving …
View article: Correction to: miR‑181d‑5p, which is upregulated in fetal growth restriction placentas, inhibits trophoblast fusion via CREBRF
Correction to: miR‑181d‑5p, which is upregulated in fetal growth restriction placentas, inhibits trophoblast fusion via CREBRF Open
View article: The Role of Genistein in Mammalian Reproduction
The Role of Genistein in Mammalian Reproduction Open
Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen. As such, genistein can bind estrogen receptors (ERα and ERβ), although…
View article: Correction to: miR‑181d‑5p, which is upregulated in fetal growth restriction placentas, inhibits trophoblast fusion via CREBRF
Correction to: miR‑181d‑5p, which is upregulated in fetal growth restriction placentas, inhibits trophoblast fusion via CREBRF Open
View article: Correction to: Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts
Correction to: Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts Open
View article: Correction to: Whole-ovary decellularization generates an effective 3D bioscaffold for ovarian bioengineering
Correction to: Whole-ovary decellularization generates an effective 3D bioscaffold for ovarian bioengineering Open
View article: Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models.
Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models. Open
View article: 3D ECM-Based Scaffolds Boost Young Cell Secretome-Derived EV Rejuvenating Effects in Senescent Cells
3D ECM-Based Scaffolds Boost Young Cell Secretome-Derived EV Rejuvenating Effects in Senescent Cells Open
Aging is a complex, multifaceted degenerative process characterized by a progressive accumulation of macroscopic and microscopic modifications that cause a gradual decline of physiological functions. During the last few years, strategies t…
View article: Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts
Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts Open
View article: Carotenoids in female and male reproduction
Carotenoids in female and male reproduction Open
View article: Synergistic Effect of miR-200 and Young Extracellular Matrix-based Bio-scaffolds to Reduce Signs of Aging in Senescent Fibroblasts
Synergistic Effect of miR-200 and Young Extracellular Matrix-based Bio-scaffolds to Reduce Signs of Aging in Senescent Fibroblasts Open
Aging is defined as a complex, multifaceted degenerative process that causes a gradual decline of physiological functions and a rising mortality risk with time. Stopping senescence or even rejuvenating the body represent one of the long-st…
View article: Impact of Aging on the Ovarian Extracellular Matrix and Derived 3D Scaffolds
Impact of Aging on the Ovarian Extracellular Matrix and Derived 3D Scaffolds Open
Advances in medical care, improvements in sanitation, and rising living standards contribute to increased life expectancy. Although this reflects positive human development, it also poses new challenges. Among these, reproductive aging is …
View article: Ovarian Decellularized Bioscaffolds Provide an Optimal Microenvironment for Cell Growth and Differentiation In Vitro
Ovarian Decellularized Bioscaffolds Provide an Optimal Microenvironment for Cell Growth and Differentiation In Vitro Open
Ovarian failure is the most common cause of infertility. Although numerous strategies have been proposed, a definitive solution for recovering ovarian functions and restoring fertility is currently unavailable. One innovative alternative m…
View article: Generation of Trophoblast-Like Cells From Hypomethylated Porcine Adult Dermal Fibroblasts
Generation of Trophoblast-Like Cells From Hypomethylated Porcine Adult Dermal Fibroblasts Open
The first differentiation event in mammalian embryos is the formation of the trophectoderm, which is the progenitor of the outer epithelial components of the placenta, and which supports the fetus during the intrauterine life. However, the…
View article: “Biomechanical Signaling in Oocytes and Parthenogenetic Cells”
“Biomechanical Signaling in Oocytes and Parthenogenetic Cells” Open
Oocyte-specific competence remains one of the major targets of current research in the field of reproduction. Several mechanisms are involved in meiotic maturation and the molecular signature of an oocyte is considered to reflect its quali…
View article: Current Advances in 3D Tissue and Organ Reconstruction
Current Advances in 3D Tissue and Organ Reconstruction Open
Bi-dimensional culture systems have represented the most used method to study cell biology outside the body for over a century. Although they convey useful information, such systems may lose tissue-specific architecture, biomechanical effe…
View article: Tracheal In Vitro Reconstruction Using a Decellularized Bio-Scaffold in Combination with a Rotating Bioreactor
Tracheal In Vitro Reconstruction Using a Decellularized Bio-Scaffold in Combination with a Rotating Bioreactor Open
View article: Using Decellularization/Recellularization Processes to Prepare Liver and Cardiac Engineered Tissues
Using Decellularization/Recellularization Processes to Prepare Liver and Cardiac Engineered Tissues Open
View article: Use of Virus-Mimicking Nanoparticles to Investigate Early Infection Events in Upper Airway 3D Models
Use of Virus-Mimicking Nanoparticles to Investigate Early Infection Events in Upper Airway 3D Models Open
View article: Creation of a Bioengineered Ovary: Isolation of Female Germline Stem Cells for the Repopulation of a Decellularized Ovarian Bioscaffold
Creation of a Bioengineered Ovary: Isolation of Female Germline Stem Cells for the Repopulation of a Decellularized Ovarian Bioscaffold Open
View article: A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells Open
Cell phenotype can be reversed or modified with different methods, with advantages and limitations that are specific for each technique. Here we describe a new strategy that combines the use of chemical epigenetic erasing with mechanosensi…
View article: Whole-ovary decellularization generates an effective 3D bioscaffold for ovarian bioengineering
Whole-ovary decellularization generates an effective 3D bioscaffold for ovarian bioengineering Open