Georgina Mancinelli
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View article: Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia
Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia Open
Cachexia is the wasting of skeletal muscle in cancer and is a major complication that impacts a person’s quality of life. We hypothesized that cachexia is mediated by dysfunction of the vascular system, which is essential for maintaining p…
View article: Cell Membrane Fatty Acids and PIPs Modulate the Etiology of Pancreatic Cancer by Regulating AKT
Cell Membrane Fatty Acids and PIPs Modulate the Etiology of Pancreatic Cancer by Regulating AKT Open
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the worst solid malignancies in regard to outcomes and metabolic dysfunction leading to cachexia. It is alarming that PDAC incidence rates continue to increase and warrant the n…
View article: Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia
Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia Open
Cancer patients experience cachexia, which is characterized by extensive skeletal muscle wasting that worsens the quality of life and increases mortality. Currently, there are no approved treatments that can effectively counteract cancer c…
View article: Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia
Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia Open
Cancer patients experience cachexia, which is characterized by extensive skeletal muscle wasting that worsens the quality of life and increases mortality. Currently, there are no approved treatments that can effectively counteract cancer c…
View article: Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index
Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index Open
INTRODUCTION: Acute pancreatitis (AP) is a healthcare challenge with considerable mortality. Treatment is limited to supportive care, highlighting the need to investigate disease drivers and prognostic markers. Activin A is an established …
View article: Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer
Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer Open
Our findings suggest that nuclear Atox1 might be a new therapeutic target as well as a new biomarker for metastatic colorectal cancer.
View article: p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity
p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity Open
Significance Although activation of PI3K p110α appears to promote pancreatic cancer development via canonical AKT signaling, in the setting of a high-fat diet (enriched in ω−6 fatty acids), unopposed p110γ inhibition poses a risk for sever…
View article: TM4SF18 is aberrantly expressed in pancreatic cancer and regulates cell growth
TM4SF18 is aberrantly expressed in pancreatic cancer and regulates cell growth Open
Current therapies for pancreatic ductal adenocarcinoma (PDAC) only modestly impact survival and can be highly toxic. A greater understanding of the molecules regulating this disease is critical for identifying new drug targets and developi…
View article: Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway
Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway Open
Pancreatic cancer remains a daunting foe despite a vast number of accumulating molecular analyses regarding the mutation and expression status of a variety of genes. Indeed, most pancreatic cancer cases uniformly present with a mutation in…
View article: Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer
Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer Open
Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed …