Georgina Mortimer
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View article: Sensitivity of RSV detection by PCR in respiratory samples is not reduced by a 24 h delay from sampling to testing with storage at room temperature
Sensitivity of RSV detection by PCR in respiratory samples is not reduced by a 24 h delay from sampling to testing with storage at room temperature Open
Respiratory Syncytial Virus (RSV) is a common cause of severe respiratory tract disease in infants, the elderly and immunocompromised patients. However, there is uncertainty as to how sample handling practices affect performance of tests t…
View article: Improving the accuracy of Respiratory Syncytial Virus (RSV) incidence estimates among hospitalised adults in Bristol, UK
Improving the accuracy of Respiratory Syncytial Virus (RSV) incidence estimates among hospitalised adults in Bristol, UK Open
Background The burden of Respiratory Syncytial Virus (RSV) infection in adults is of interest in the context of recently-licensed vaccines. However, burden estimates are affected by test error associated with the testing platform, and numb…
View article: Islet autoantibody frequency in relatives of children with type 1 diabetes who have a type 2 diabetes diagnosis
Islet autoantibody frequency in relatives of children with type 1 diabetes who have a type 2 diabetes diagnosis Open
Aim This study aimed to evaluate characteristics of autoimmunity in individuals who have a type 2 diagnosis and are relatives of children with type 1 diabetes. Methods Pre‐diagnosis samples (median 17 months before onset) from relatives wh…
View article: Increased levels of anti-BSA antibodies in children with Down syndrome
Increased levels of anti-BSA antibodies in children with Down syndrome Open
Introduction Autoimmune diabetes occurs more often in the first 2 years of life in children with Down syndrome (DS) compared with the general population. We previously observed increased frequencies of islet autoantibodies, including insul…
View article: Development and evaluation of low-volume tests to detect and characterize antibodies to SARS-CoV-2
Development and evaluation of low-volume tests to detect and characterize antibodies to SARS-CoV-2 Open
Low-volume antibody assays can be used to track SARS-CoV-2 infection rates in settings where active testing for virus is limited and remote sampling is optimal. We developed 12 ELISAs detecting total or antibody isotypes to SARS-CoV-2 nucl…
View article: Establishing breast feeding in infants with Down syndrome: the FADES cohort experience
Establishing breast feeding in infants with Down syndrome: the FADES cohort experience Open
Objective To describe breastfeeding prevalence and maternal experience in infants with trisomy 21. Design Longitudinal cohort study. Setting Participants from UK recruited through websites, social media and local collaborators: neonatologi…
View article: The measurement of autoantibodies to insulin informs diagnosis of diabetes in a childhood population negative for other autoantibodies
The measurement of autoantibodies to insulin informs diagnosis of diabetes in a childhood population negative for other autoantibodies Open
Aims Some childhood type 1 diabetes cases are islet autoantibody negative at diagnosis. Potential explanations include misdiagnosis of genetic forms of diabetes or insufficient islet autoantibody testing. Many NHS laboratories offer combin…
View article: The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic variants
The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic variants Open
The clinical usefulness of post-diagnosis islet autoantibody levels is unclear and factors that drive autoantibody persistence are poorly defined in type 1 diabetes (T1D). Our aim was to characterise the longitudinal loss of islet autoanti…
View article: Development and evaluation of low-volume tests to detect and characterise antibodies to SARS-CoV-2
Development and evaluation of low-volume tests to detect and characterise antibodies to SARS-CoV-2 Open
Low-volume antibody assays can be used to track SARS-CoV-2 infection rates in settings where active testing for virus is limited and remote sampling is optimal. We developed 12 ELISAs detecting total or antibody isotypes to SARS-CoV-2 nucl…
View article: Early Onset of Autoimmune Diabetes in Children with Down Syndrome—Two Separate Aetiologies or an Immune System Pre-Programmed for Autoimmunity?
Early Onset of Autoimmune Diabetes in Children with Down Syndrome—Two Separate Aetiologies or an Immune System Pre-Programmed for Autoimmunity? Open
Purpose of Review An increased frequency of autoimmunity in children with Down syndrome (DS) is well described but few studies have investigated the underlying mechanisms. Recent immune system investigation of individuals with DS may shed …
View article: Maternal Microchimerism in Cord Blood and Risk of Celiac Disease in Childhood
Maternal Microchimerism in Cord Blood and Risk of Celiac Disease in Childhood Open
Objectives: During pregnancy, small quantities of maternal cells are naturally transmitted to the fetus. This transmission, termed maternal microchimerism (MMc), has been implicated in autoimmune diseases but its potential role is unclear.…
View article: Maternal microchimerism in cord blood and risk of childhood‐onset type 1 diabetes
Maternal microchimerism in cord blood and risk of childhood‐onset type 1 diabetes Open
Our findings did not support the hypothesis that the degree of MMc in cord blood predict T1D risk. The potential subgroup association with T1D risk should be replicated in a larger cohort.
View article: Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity Open
Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play major roles in the control of cell proliferation and tumorigenesis. We have identified completely novel roles for Merlin and the Hippo pathway effector …