Georgios K. Glantzounis
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View article: The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Open
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is now recognized as the leading cause of chronic liver disease worldwide. MASLD spans a spectrum ranging from…
View article: The Role of Preoperative Serum Phosphate Screening in Thyroidectomy: Practical Reflections and Future Directions
The Role of Preoperative Serum Phosphate Screening in Thyroidectomy: Practical Reflections and Future Directions Open
View article: Exploring the Role of Metabolic Hyperferritinaemia (MHF) in Steatotic Liver Disease (SLD) and Hepatocellular Carcinoma (HCC)
Exploring the Role of Metabolic Hyperferritinaemia (MHF) in Steatotic Liver Disease (SLD) and Hepatocellular Carcinoma (HCC) Open
The increasing prevalence of the spectrum of Steatotic Liver Disease (SLD), including Metabolic-Associated Steatotic Liver Disease (MASLD), Metabolic-Associated Steatohepatitis (MASH), and progression to Cirrhosis and Hepatocellular Carcin…
View article: Anatomical Schemata Revealed by the Critical View of Safety Approach: A Proposal of the Hellenic Task Force on the Typology of Safe Laparoscopic Cholecystectomy (HETALCHO)
Anatomical Schemata Revealed by the Critical View of Safety Approach: A Proposal of the Hellenic Task Force on the Typology of Safe Laparoscopic Cholecystectomy (HETALCHO) Open
Background and objectives: Laparoscopic cholecystectomy (LC) is the most commonly performed operation in general surgery in the Western World. Gallbladder surgery, although most of the time simple, always offers the possibility of unpleasa…
View article: Development and internal validation of a clinical prediction model for serious complications after emergency laparotomy
Development and internal validation of a clinical prediction model for serious complications after emergency laparotomy Open
Purpose Emergency laparotomy (EL) is a common operation with high risk for postoperative complications, thereby requiring accurate risk stratification to manage vulnerable patients optimally. We developed and internally validated a predict…
View article: Significant Elevation of CA 19-9 Levels Due to Acute Xanthogranulomatous Cholecystitis and Following mRNA COVID-19 Vaccination: A Case Report and Literature Review
Significant Elevation of CA 19-9 Levels Due to Acute Xanthogranulomatous Cholecystitis and Following mRNA COVID-19 Vaccination: A Case Report and Literature Review Open
Objectives: Carbohydrate antigen (CA 19-9) is a tumour marker usually elevated in upper-gastrointestinal and pancreaticobiliary malignancies, yet some studies reported pathological increments in patients with biliary obstruction. However, …
View article: The Role of Oxidative Stress and Cellular Senescence in the Pathogenesis of Metabolic Associated Fatty Liver Disease and Related Hepatocellular Carcinoma
The Role of Oxidative Stress and Cellular Senescence in the Pathogenesis of Metabolic Associated Fatty Liver Disease and Related Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) represents a worryingly increasing cause of malignancy-related mortality, while Metabolic Associated Fatty Liver Disease (MAFLD) is going to become its most common cause in the next decade. Understanding the …
View article: The Role of Preoperative Chemotherapy in the Management of Synchronous Resectable Colorectal Liver Metastases: A Meta-Analysis
The Role of Preoperative Chemotherapy in the Management of Synchronous Resectable Colorectal Liver Metastases: A Meta-Analysis Open
Background: The indications of preoperative chemotherapy, for initially resectable synchronous colorectal liver metastases, remain controversial. This meta-analysis aimed to assess the efficacy and safety of preoperative chemotherapy in su…
View article: Significant CA 19-9 Elevation (> 10000 IU/mL) due to Recurrent Episodes of Acute Cholecystitis with Rupture to the Liver: A Case Report
Significant CA 19-9 Elevation (> 10000 IU/mL) due to Recurrent Episodes of Acute Cholecystitis with Rupture to the Liver: A Case Report Open
View article: Accurate Characterization of Bladder Cancer Cells with Intraoperative Flow Cytometry
Accurate Characterization of Bladder Cancer Cells with Intraoperative Flow Cytometry Open
Bladder cancer represents a major health issue. Transurethral resection is the first line treatment and an accurate assessment of tumor margins might warrant complete tumor removal. Genomic instability and proliferative potential are commo…
View article: The Hellenic Emergency Laparotomy Study (HELAS): A Prospective Multicentre Study on the Outcomes of Emergency Laparotomy in Greece
The Hellenic Emergency Laparotomy Study (HELAS): A Prospective Multicentre Study on the Outcomes of Emergency Laparotomy in Greece Open
Background Emergency laparotomy (EL) is accompanied by high post‐operative morbidity and mortality which varies significantly between countries and populations. The aim of this study is to report outcomes of emergency laparotomy in Greece …
View article: Individualized Approach in the Surgical Management of Hepatocellular Carcinoma: Results from a Greek Multicentre Study
Individualized Approach in the Surgical Management of Hepatocellular Carcinoma: Results from a Greek Multicentre Study Open
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the third leading cause of death worldwide. The management of HCC is complex, with surgical treatment providing long-term survival in eligible patients.…
View article: Colour Duplex and/or Contrast-Enhanced Ultrasound Compared with Computed Tomography Angiography for Endoleak Detection after Endovascular Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-Analysis
Colour Duplex and/or Contrast-Enhanced Ultrasound Compared with Computed Tomography Angiography for Endoleak Detection after Endovascular Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-Analysis Open
This study aims to assess the role of Color Duplex Ultrasound with or without contrast media for surveillance following endovascular aortic aneurysm repair (EVAR). A systematic search of the literature published until April 2022 was perfor…
View article: Plasma VEGF and Leptin Values in Patients With Gastric Intestinal Metaplasia and Metabolic Syndrome
Plasma VEGF and Leptin Values in Patients With Gastric Intestinal Metaplasia and Metabolic Syndrome Open
Intestinal metaplasia of the stomach (IM) is considered a pre-cancerous lesion and is a potential precursor to adenocarcinoma. Metabolic syndrome (MetS) has been associated with lesions to the gastrointestinal tract such as the risk of dev…
View article: Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis
Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis Open
Introduction The mechanisms underlying high drug resistance and relapse rates after multi-modal treatment in patients with colorectal cancer (CRC) and liver metastasis (LM) remain poorly understood. Objective We evaluate the potential tran…
View article: Autophagy and Exosomes: Cross-Regulated Pathways Playing Major Roles in Hepatic Stellate Cells Activation and Liver Fibrosis
Autophagy and Exosomes: Cross-Regulated Pathways Playing Major Roles in Hepatic Stellate Cells Activation and Liver Fibrosis Open
Chronic liver injury, regardless of the underlying disease, results in gradual alteration of the physiological hepatic architecture and in excessive production of extracellular matrix, eventually leading to cirrhosis Liver cellular archite…
View article: The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma
The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma Open
Hepatocarcinogenesis is a long process with a complex pathophysiology. The current therapeutic options for HCC management, during the advanced stage, provide short-term survival ranging from 10–14 months. Autophagy acts as a double-edged s…
View article: Description of a Recovery Model in Rabbits for the Study of the Late Phase of Liver Ischemia-Reperfusion Injury
Description of a Recovery Model in Rabbits for the Study of the Late Phase of Liver Ischemia-Reperfusion Injury Open
This anesthetic recovery model permitted avoidance of hypoxia and respiratory acidosis, allowing the study of the late phase of I/R injury.
View article: Metronomic chemotherapy with cyclophosphamide for the treatment of advanced hepatocellular cancer: A case report
Metronomic chemotherapy with cyclophosphamide for the treatment of advanced hepatocellular cancer: A case report Open
Large multi-centered clinical trials have to be planned to investigate the precise role of cyclophosphamide in the therapy of hepatocellular cancer while defining the patients' profile that will benefit most from cyclophosphamide.
View article: Surgical Therapy of Hepatocellular Carcinoma: State of the Art Liver Resection
Surgical Therapy of Hepatocellular Carcinoma: State of the Art Liver Resection Open
Hepatocellular carcinoma (HCC) represents the third most common cause of cancer-related death, showing incremental growth rates throughout the last decades. HCC requires multidisciplinary approach in a group of patients suffering from unde…
View article: Touch Imprint Intraoperative Flow Cytometry as a Complementary Tool for Detailed Assessment of Resection Margins and Tumor Biology in Liver Surgery for Primary and Metastatic Liver Neoplasms
Touch Imprint Intraoperative Flow Cytometry as a Complementary Tool for Detailed Assessment of Resection Margins and Tumor Biology in Liver Surgery for Primary and Metastatic Liver Neoplasms Open
Liver resection is the main treatment for primary and metastatic liver tumors in order to achieve long-term survival with good quality of life. The ultimate goal of surgical oncology is to achieve complete tumor removal with adequate clear…
View article: Proof-of-concept pilot study on comprehensive spatiotemporal intra-patient heterogeneity for colorectal cancer with liver metastasis
Proof-of-concept pilot study on comprehensive spatiotemporal intra-patient heterogeneity for colorectal cancer with liver metastasis Open
Purpose The mechanisms underlying high drug resistance and relapse rates after multi-modal treatment in patients with colorectal cancer (CRC) and liver metastasis (LM) remain poorly understood. We evaluate the potential translational impli…
View article: Radiological simultaneous portohepatic vein embolization (RASPE) and major hepatectomy with hepatocellular carcinoma (HCC)
Radiological simultaneous portohepatic vein embolization (RASPE) and major hepatectomy with hepatocellular carcinoma (HCC) Open
View article: Intrahepatic intraductal papillary cystic neoplasm of the bile duct: A case report
Intrahepatic intraductal papillary cystic neoplasm of the bile duct: A case report Open
Complete surgical resection (R0) with close postoperative follow-up offers long-term survival.
View article: Indocyanine green fluorescence guided laparoscopic hepatectomy of segment VI for metachronous colorectal liver metastases in a severely obese patient
Indocyanine green fluorescence guided laparoscopic hepatectomy of segment VI for metachronous colorectal liver metastases in a severely obese patient Open
View article: Recent advances in the surgical management of hepatocellular carcinoma
Recent advances in the surgical management of hepatocellular carcinoma Open
The incidence of hepatocellular carcinoma (HCC) is increasing, despite effective antiviral treatment for hepatitis B (HBV) and C virus infection and the application of preventive measures such as vaccination at birth against HBV infection.…
View article: The role of hepatectomy in patients over 75 years old. Results from a ten- year retrospective comparative study
The role of hepatectomy in patients over 75 years old. Results from a ten- year retrospective comparative study Open
View article: Metronomic Chemotherapy with Cyclophosphamide as a Second Line Treatment in Advanced Hepatocellular Cancer: A Case Report
Metronomic Chemotherapy with Cyclophosphamide as a Second Line Treatment in Advanced Hepatocellular Cancer: A Case Report Open
View article: Expression of Syndecan-1 in Chronic Liver Diseases: Correlation With Hepatic Fibrosis
Expression of Syndecan-1 in Chronic Liver Diseases: Correlation With Hepatic Fibrosis Open
In CLDs, syndecan-1 immunohisto-chemical overexpression was found to be positively correlated with the severity of fibrosis, suggesting its probable role in hepatic fibrogenesis.
View article: Indocyanine green fluorescence perfusion-guided total laparoscopic right hepatectomy for a large symptomatic hemorrhagic liver cyst
Indocyanine green fluorescence perfusion-guided total laparoscopic right hepatectomy for a large symptomatic hemorrhagic liver cyst Open