Explanipedia

Postprostatectomy Radiotherapy Timing and Long-Term Health-Related Quality of Life Open

Sagar A. Patel, Dattatraya Patil, Joseph A. Smith, Christopher S. Saigal, Mark S. Litwin , et al. · 2024

Importance The association between radiotherapy (RT) timing after radical prostatectomy and long-term patient-reported health-related quality of life (HRQOL) in men with prostate cancer is unknown. Objective To measure long-term HRQOL in m…

Effects of protein restriction on insulin-like growth factor (IGF)-1 in men with prostate cancer: results from a randomized clinical trial Open

María Lastra Cagigas, Giovanni Fiorito, Beatrice Bertozzi, Andrius Masedunskas, Edda Cava , et al. · 2024

Prostate-Specific Membrane Antigen–Targeted Imaging and Its Correlation with HOXB13 Expression Open

Duminduni H. Angappulige, Nimrod S. Barashi, Nicholas Pickersgill, Cody Weimholt, Jingqin Luo , et al. · 2024

Homeobox 13 (HOXB13) is an oncogenic transcription factor that directly regulates expression of folate hydrolase 1, which encodes prostate-specific membrane antigen (PSMA). HOXB13 is expressed in primary and metastatic prostate cancers (PC…

Symptomatic Benign Prostatic Hyperplasia with Suppressed Epigenetic Regulator HOXB13 Shows a Lower Incidence of Prostate Cancer Development Open

Nimrod S. Barashi, Tiandao Li, Duminduni H. Angappulige, Bo Zhang, Harry O’Gorman , et al. · 2024

Our objective was to identify variations in gene expression that could help elucidate the pathways for the development of prostate cancer (PCa) in men with Benign Prostatic Hyperplasia (BPH). We included 98 men with BPH, a positive prostat…

The Prostatype® Test, a Novel Genomic Classifier, Accurately Predicts Adverse Pathology (AP) at Radical Prostatectomy (RP) Open

Erik Berglund, Szilvia Gaal, Gerald L. Andriole · 2023

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Open

David V. Conti, B.F. Darst, Lilit C. Moss, Edward J. Saunders, X. Sheng , et al. · 2023

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 c…

Diagnostic Performance and Safety of Positron Emission Tomography with 18F-rhPSMA-7.3 in Patients with Newly Diagnosed Unfavourable Intermediate- to Very-high-risk Prostate Cancer: Results from a Phase 3, Prospective, Multicentre Study (LIGHTHOUSE) Open

Devaki Shilpa Surasi, Matthias Eiber, Tobias Maurer, Mark A. Preston, Brian T. Helfand , et al. · 2023

In order to select the most appropriate treatment for patients with prostate cancer, it is critical to diagnose the disease burden accurately at initial diagnosis. In this study, we investigated a new diagnostic imaging agent in a large po…

Impact of 18F-fluciclovine PET/CT on plans for androgen deprivation therapy in patients with biochemical recurrence of prostate cancer: data analysis from two prospective clinical trials Open

Gerald L. Andriole, Andrew Scarsbrook, Bital Savir-Baruch · 2023

Data from Statin Use, Serum Lipids, and Prostate Inflammation in Men with a Negative Prostate Biopsy: Results from the REDUCE Trial Open

Emma H. Allott, Lauren E. Howard, Adriana C. Vidal, Daniel M. Moreira, Ramiro Castro‐Santamaria , et al. · 2023

Statin use is associated with lower advanced prostate cancer risk. In addition to cholesterol lowering, statins have systemic anti-inflammatory properties. However, their effect on histologic prostate inflammation is not well understood, p…

Data from Smoking Is Associated with Acute and Chronic Prostatic Inflammation: Results from the REDUCE Study Open

Daniel M. Moreira, J. Curtis Nickel, Leah R. Gerber, Roberto L. Müller, Gerald L. Andriole , et al. · 2023

Both anti- and proinflammatory effects of cigarette smoking have been described. As prostate inflammation is common, we hypothesized smoking could contribute to prostate inflammation. Thus, we evaluated the association of smoking status wi…

Supplementary Table S1 from Statin Use, Serum Lipids, and Prostate Inflammation in Men with a Negative Prostate Biopsy: Results from the REDUCE Trial Open

Emma H. Allott, Lauren E. Howard, Adriana C. Vidal, Daniel M. Moreira, Ramiro Castro‐Santamaria , et al. · 2023

Supplementary Table S1. Demographic characteristics of REDUCE participants in the analytic cohort, and in the group excluded due to missing lipid levels.

Supplementary Table S1 from Statin Use, Serum Lipids, and Prostate Inflammation in Men with a Negative Prostate Biopsy: Results from the REDUCE Trial Open

Emma H. Allott, Lauren E. Howard, Adriana C. Vidal, Daniel M. Moreira, Ramiro Castro‐Santamaria , et al. · 2023

Supplementary Table S1. Demographic characteristics of REDUCE participants in the analytic cohort, and in the group excluded due to missing lipid levels.

Data from Smoking Is Associated with Acute and Chronic Prostatic Inflammation: Results from the REDUCE Study Open

Daniel M. Moreira, J. Curtis Nickel, Leah Gerber, Roberto L. Müller, Gerald L. Andriole , et al. · 2023

Both anti- and proinflammatory effects of cigarette smoking have been described. As prostate inflammation is common, we hypothesized smoking could contribute to prostate inflammation. Thus, we evaluated the association of smoking status wi…

Supplemental tables 1-5 from Smoking Is Associated with Acute and Chronic Prostatic Inflammation: Results from the REDUCE Study Open

Daniel M. Moreira, J. Curtis Nickel, Leah R. Gerber, Roberto L. Müller, Gerald L. Andriole , et al. · 2023

Supplemental tables 1-5. Supplemental Table 1: Inflammation by smoking status. Supplemental Table 2: Inflammation by treatment arm. Supplemental Table 3: Univariable odds ratios of inflammation by smoking status stratified by treatment arm…

Data from Statin Use, Serum Lipids, and Prostate Inflammation in Men with a Negative Prostate Biopsy: Results from the REDUCE Trial Open

Emma H. Allott, Lauren E. Howard, Adriana C. Vidal, Daniel M. Moreira, Ramiro Castro‐Santamaria , et al. · 2023

Statin use is associated with lower advanced prostate cancer risk. In addition to cholesterol lowering, statins have systemic anti-inflammatory properties. However, their effect on histologic prostate inflammation is not well understood, p…

Supplemental tables 1-5 from Smoking Is Associated with Acute and Chronic Prostatic Inflammation: Results from the REDUCE Study Open

Daniel M. Moreira, J. Curtis Nickel, Leah R. Gerber, Roberto L. Müller, Gerald L. Andriole , et al. · 2023

Supplemental tables 1-5. Supplemental Table 1: Inflammation by smoking status. Supplemental Table 2: Inflammation by treatment arm. Supplemental Table 3: Univariable odds ratios of inflammation by smoking status stratified by treatment arm…

Supplementary Figure from Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer Open