Gerald C. Chu
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View article: Visualizing androgen signaling and assessing its interaction with canonical Wnt signaling pathways in prostate development, morphogenesis, and regeneration
Visualizing androgen signaling and assessing its interaction with canonical Wnt signaling pathways in prostate development, morphogenesis, and regeneration Open
The androgen receptor (AR) is a nuclear hormone receptor, and its activation through binding to androgens is essential for prostate development, morphogenesis, growth, and tumorigenesis. Although significant efforts have been devoted to un…
View article: Supplementary Figure 6 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations
Supplementary Figure 6 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 239KB, Western blot showed inhibition of autophagy in Atg5 and Atg7 knockdown cell lines.
Supplementary Figure S2 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Figure S2 PDF file 112K,Data related to the establishment and confirmation of CRC cell lines expressing different mutant forms of Ras
View article: Data from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations
Data from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
Pancreatic ductal adenocarcinoma is refractory to available therapies. We have previously shown that these tumors have elevated autophagy and that inhibition of autophagy leads to decreased tumor growth. Using an autochthonous model of pan…
Supplementary Figure S2 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Figure S2 PDF file 112K,Data related to the establishment and confirmation of CRC cell lines expressing different mutant forms of Ras
Supplementary Table 1 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 18KB, Summary of genetic mutations in different human pancreatic tumor xenografts.
Data from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
Pancreatic ductal adenocarcinoma is refractory to available therapies. We have previously shown that these tumors have elevated autophagy and that inhibition of autophagy leads to decreased tumor growth. Using an autochthonous model of pan…
View article: Supplementary Tables 1-2, Figures 1-8 from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network
Supplementary Tables 1-2, Figures 1-8 from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network Open
Supplementary Tables 1-2, Figures 1-8 from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network
Supplementary Figure S4 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Figure S4 PDF file 80K, Data related to the characterization of cell lines expressing mutant N-Ras. In addition, examples of quantitative western blots are shown
View article: Supplementary Tables 1-2, Figures 1-8 from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network
Supplementary Tables 1-2, Figures 1-8 from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network Open
Supplementary Tables 1-2, Figures 1-8 from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network
View article: Data from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network
Data from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network Open
Initiation of pancreatic ductal adenocarcinoma (PDAC) is driven by oncogenic KRAS mutation, and disease progression is associated with frequent loss of tumor suppressors. In this study, human PDAC genome analyses revealed frequent deletion…
Supplementary Table 1 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 18KB, Summary of genetic mutations in different human pancreatic tumor xenografts.
Supplementary Figure 3 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 337KB, IHC staining shows absence of Atg5 expression and diminished autophagosomes in tumors with Atg5 deletion.
Supplementary Figure 4 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 283KB, Western blot on tumor lines derived from primary tumors confirmed Atg5 status and also showed loss of p53.
Supplementary Figure 1 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 181KB, Deletion of Atg5 in pancreata disrupts beta-islets over time.
Data from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
N-RAS is one member of a family of oncoproteins that are commonly mutated in cancer. Activating mutations in NRAS occur in a subset of colorectal cancers, but little is known about how the mutant protein contributes to the onset and progre…
Supplementary Figure 2 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 244KB, Deletion of Atg5 in lslKrasG12D, p53L/+, pdxCre+ mice disrupts the exocrine pancreas.
Supplementary Figure 3 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 337KB, IHC staining shows absence of Atg5 expression and diminished autophagosomes in tumors with Atg5 deletion.
Supplementary Figure S4 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Figure S4 PDF file 80K, Data related to the characterization of cell lines expressing mutant N-Ras. In addition, examples of quantitative western blots are shown
Supplementary Figure S5 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Figure S5 PDF file 101K, Confirmation of RAF knockdown cells
Supplementary Figure 4 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 283KB, Western blot on tumor lines derived from primary tumors confirmed Atg5 status and also showed loss of p53.
Supplementary Figure 6 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 239KB, Western blot showed inhibition of autophagy in Atg5 and Atg7 knockdown cell lines.
Supplementary Figure Legends from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Figure Legends PDF file 72K, Legends for Supplementary Figures 1-6
Supplementary Figure 5 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 162KB, PCR and western blot confirmed the genotype of mouse cell lines with different p53 status.
Supplementary Figure 1 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 181KB, Deletion of Atg5 in pancreata disrupts beta-islets over time.
Supplementary Figure S3 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Figure S3 PDF file 66K,Additional data related to the proliferative and apoptotic phenotypes of CRC cells expressing mutant Ras
Supplementary Figure S1 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Figure S1 PDF file 160K, Additional data relating to the inflammatory phenotypes of WT and N-Ras mutant animals
Supplementary Figure 2 from Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations Open
PDF file - 244KB, Deletion of Atg5 in lslKrasG12D, p53L/+, pdxCre+ mice disrupts the exocrine pancreas.
Supplementary Figure S6 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Figure S6 PDF file 117K, Additional data concerning the relationship between mutant N-Ras and Stat3.
Supplementary Tables 1 and 2 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression Open
Supplementary Tables 1 and 2 PDF file 91K, Table 1 contains clinical and genotypic data from the patient cohort referred to in Fig. 6. Table 2 contains shRNA target sequences