Explanipedia

Five-year follow-up of a phase I trial of donor-derived modified immune cell infusion in kidney transplantation Open

Matthias Schaier, Christian Morath, Lei Wang, Christian Kleist, Gerhard Opelz , et al. · 2023

Background The administration of modified immune cells (MIC) before kidney transplantation led to specific immunosuppression against the allogeneic donor and a significant increase in regulatory B lymphocytes. We wondered how this approach…

Modified Immune Cell (MIC) Therapy disrupts Tertiary Lymphoid Structures in Murine Lupus Nephritis Open

Gerald Ponath, Claudius Speer, Iris Arnold, Åsa Hidmark, Lei Wang , et al. · 2023

Induction of tolerance can be achieved with Modified Immune Cells (MIC) by infusion of mononuclear cells challenged with mitomycin C (MMC). Although MIC treatment has been successful in several animal models for autoimmunity and in clinica…

Induction of Long-Lasting Regulatory B Lymphocytes by Modified Immune Cells in Kidney Transplant Recipients Open

Christian Morath, Matthias Schaier, Eman H. Ibrahim, Lei Wang, Christian Kleist , et al. · 2022

Significance Statement In previous work, the authors demonstrated that kidney transplant recipients developed donor-specific unresponsiveness when they were given a pretransplant infusion of modified donor-derived PBMCs. In this study, the…

Humoral Responses to Single-Dose BNT162b2 mRNA Vaccination in Dialysis Patients Previously Infected With SARS-CoV-2 Open

Claudius Speer, Christian Morath, Maximilian Töllner, Mirabel Buylaert, Daniel Göth , et al. · 2021

Seroconversion rates following infection and vaccination are lower in dialysis patients compared to healthy controls. There is an urgent need for the characterization of humoral responses and success of a single-dose SARS-CoV-2 vaccination…

Heterologous ChAdOx1 nCoV-19/BNT162b2 Prime-Boost Vaccination Induces Strong Humoral Responses among Health Care Workers Open

Louise Benning, Maximilian Töllner, Åsa Hidmark, Matthias Schaier, Christian Nußhag , et al. · 2021

Despite limited data on safety and immunogenicity, heterologous prime-boost vaccination is currently recommended for individuals with ChAdOx1 nCoV-19 prime immunization in certain age groups. In this prospective, single-center study we inc…

Early Humoral Responses of Hemodialysis Patients after COVID-19 Vaccination with BNT162b2 Open

Claudius Speer, Daniel Göth, Louise Benning, Mirabel Buylaert, Matthias Schaier , et al. · 2021

Background and objectives Patients receiving hemodialysis are at high risk for both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe coronavirus disease 2019. A lifesaving vaccine is available, but sensitiv…

Tet2 Controls β cells Responses to Inflammation in Type 1 Diabetes Open

Jinxiu Rui, Songyan Deng, Gerald Ponath, Romy Kursawe, Nathan Lawlor , et al. · 2020

β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). We identified a novel role of Tet2 in regulating immune killing of β cells. Tet2 is induced in murine and human β cells with inflammation but its expr…

Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS Open

Liliana E. Lucca, Benjamin A. Lerner, Calvin Park, Danielle DeBartolo, Brian Harnett , et al. · 2020

The opposite patterns of TIGIT expression in the CNS between MS and glioblastoma reflects the divergent features of the immune response in these 2 CNS diseases. These data raise the possibility that anti-TIGIT therapy may be beneficial for…

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions Open

Calvin Park, Gerald Ponath, Maya Levine-Ritterman, Edward Bull, Eric Swanson , et al. · 2019

Activated myeloid cells and astrocytes are the predominant cell types in active multiple sclerosis (MS) lesions. Both cell types can adopt diverse functional states that play critical roles in lesion formation and resolution. In order to i…

Differential Expression of the T cell Inhibitor TIGIT in Glioblastoma and Multiple Sclerosis Open

Liliana E. Lucca, Benjamin A. Lerner, Danielle DeBartolo, Calvin Park, Gerald Ponath , et al. · 2019

To identify co-inhibitory immune pathways important in the brain, we hypothesized that comparison of T cells in lesions from patients with MS with tumor infiltrating T cells (TILs) from patients with GBM may reveal novel targets for immuno…

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis Open

Gerald Ponath, Matthew R. Lincoln, Maya Levine-Ritterman, Calvin Park, Somiah Dahlawi , et al. · 2018

Astrocytes play a crucial role in the formation and evolution of MS lesions – Yes Open

David Pitt, Gerald Ponath · 2018

Myeloid cell plasticity in the evolution of central nervous system autoimmunity Open

David A. Giles, Jesse M. Washnock-Schmid, Patrick C. Duncker, Somiah Dahlawi, Gerald Ponath , et al. · 2017

Objective Myeloid cells, including macrophages and dendritic cells, are a prominent component of central nervous system (CNS) infiltrates during multiple sclerosis (MS) and the animal model experimental autoimmune encephalomyelitis (EAE). …

Enhanced Astrocyte Responses are Driven by a Genetic Risk Allele Associated with Multiple Sclerosis Open

Gerald Ponath, Matthew R. Lincoln, Somiah Dahlawi, Mayyan Mubarak, Tomokazu S. Sumida , et al. · 2017

Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effec…

Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology Open

Gerald Ponath, Sriram Ramanan, Mayyan Mubarak, William Housley, Seung‐Hoon Lee , et al. · 2016

Astrocytes are key players in the pathology of multiple sclerosis and can assume beneficial and detrimental roles during lesion development. The triggers and timing of the different astroglial responses in acute lesions remain unclear. Ast…

CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment Open

Yonghao Cao, Alyssa Nylander, Sriram Ramanan, Brittany A. Goods, Gerald Ponath , et al. · 2016

Antivascular endothelial growth factor (anti-VEGF) therapy has revolutionised the treatment of wet age-related macular degeneration (wAMD). Recent research has focused on evaluating competing agents and alternative dosage regimens, providi…

Serum S100B Protein is Specifically Related to White Matter Changes in Schizophrenia Open

Berko Milleit, Stefan Smesny, Matthias Rothermundt, Christoph Preul, Matthias L. Schroeter , et al. · 2016

S100B-associated alterations of white matter are shown to be existent already at time of first manifestation of psychosis and are distinct from findings in recurrent episode patients. This suggests involvement of S100B in an ongoing and dy…

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