Gerald Rimbach
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View article: A Nutritional Evaluation of Plant-Based Meat and Sausage Analogues
A Nutritional Evaluation of Plant-Based Meat and Sausage Analogues Open
Plant-based meat and sausage analogues (PBMAs) are gaining popularity due to growing concerns about the health, environmental, and ethical impacts of animal-based foods. In the present study, we compared the nutritional quality of 298 PBMA…
View article: Homeostatic Counter‐Regulation Mediates Spermidine‐Induced Triacylglyceride Reduction in <i>Drosophila melanogaster</i> —From Phenotype to Molecular Mechanism
Homeostatic Counter‐Regulation Mediates Spermidine‐Induced Triacylglyceride Reduction in <i>Drosophila melanogaster</i> —From Phenotype to Molecular Mechanism Open
The polyamines putrescine, spermidine (Spd), and spermine have essential functions in cell growth and proliferation. Previous research has unveiled a potential link between polyamine metabolism and triacylglyceride (TAG) homeostasis. In th…
View article: Bioenergetic signatures of circulating blood cells as biosensors of metabolic health in food-producing animals
Bioenergetic signatures of circulating blood cells as biosensors of metabolic health in food-producing animals Open
The intensification of animal production has substantially increased productivity, yet it has concurrently increased the metabolic vulnerability of livestock and poultry. Traditional biomarkers often lack sensitivity and fail to capture ea…
View article: Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Salicornia europaea Extract Through Tor Signaling Modulation in Drosophila
Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Salicornia europaea Extract Through Tor Signaling Modulation in Drosophila Open
Background/Objectives: Some marine plants and algae are known to exert health benefits. However, the long-term effects and underlying mechanisms of these health benefits are still poorly understood. For this reason, we have investigated an…
View article: Correlates of serum holo-Transcobalamin in the elderly general population
Correlates of serum holo-Transcobalamin in the elderly general population Open
Background Holo-Transcobalamin (holo-TC) is the biologically active form of vitamin B12, an essential vitamin that is only contained in animal derived food products. While severe vitamin B12 deficiency has well known clinical consequences,…
View article: A diet-based Drosophila melanogaster model for the in vivo pharmacological evaluation of α-glucosidase inhibitors
A diet-based Drosophila melanogaster model for the in vivo pharmacological evaluation of α-glucosidase inhibitors Open
The intestinal α-glucosidases maltase and sucrase break down the dietary disaccharides maltose and sucrose respectively into their monosaccharides for absorption by the body. These enzymes are therefore drug targets for hyperglycaemia-asso…
View article: Higher Urinary Iron Levels Are Associated with Kidney Dysfunction, Tubular Damage, and Increased Mortality in Kidney Transplant Recipients
Higher Urinary Iron Levels Are Associated with Kidney Dysfunction, Tubular Damage, and Increased Mortality in Kidney Transplant Recipients Open
Key Points Kidney transplant recipients have higher urinary iron levels than controls and urinary iron levels are increased with oral iron supplementation. Urinary iron levels are associated with worse kidney function, increased tubular da…
View article: The postbiotic potential of Aspergillus oryzae – a narrative review
The postbiotic potential of Aspergillus oryzae – a narrative review Open
The filamentous fungus Aspergillus oryzae has a long tradition in East Asian food processing. It is therefore not surprising that in recent years fermentation products of A. oryzae have attracted attention in the emerging field of postbiot…
View article: A New LC-MS/MS-Based Method for the Simultaneous Detection of α-Tocopherol and Its Long-Chain Metabolites in Plasma Samples Using Stable Isotope Dilution Analysis
A New LC-MS/MS-Based Method for the Simultaneous Detection of α-Tocopherol and Its Long-Chain Metabolites in Plasma Samples Using Stable Isotope Dilution Analysis Open
Background: Our study presented a novel LC-MS/MS method for the simultaneous quantification of α-tocopherol (α-TOH) and its phase II metabolites, α-13′-COOH and α-13′-OH, in human serum using deuterium-labeled internal standards (d6-α-TOH,…
View article: Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein–Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1)
Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein–Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1) Open
As a component of circulating lipoproteins, APOE binds to cell surface receptors mediating lipoprotein metabolism and cholesterol transport. A growing body of evidence, including the identification of a broad variety of cellular proteins i…
View article: A marsh samphire (<i>Salicornia europaea</i>) extract induces a strictly sex-specific, Tor-signaling-dependent extension of lifespan and exhibits anti-obesogenic properties
A marsh samphire (<i>Salicornia europaea</i>) extract induces a strictly sex-specific, Tor-signaling-dependent extension of lifespan and exhibits anti-obesogenic properties Open
Summary We have studied the health-promoting properties of the marsh samphire Salicornia europaea by employing the fruit fly Drosophila melanogaster . Supplementing a standard diet with 0.2% of an aqueous extract of this halophilic plant (…
View article: A comprehensive in-vitro/in-vivo screening toolbox for the elucidation of glucose homeostasis modulating properties of plant extracts (from roots) and its bioactives
A comprehensive in-vitro/in-vivo screening toolbox for the elucidation of glucose homeostasis modulating properties of plant extracts (from roots) and its bioactives Open
Plant extracts are increasingly recognized for their potential in modulating (postprandial) blood glucose levels. In this context, root extracts are of particular interest due to their high concentrations and often unique spectrum of plant…
View article: Holo-transcobalamin is not associated with the risk of all-cause mortality in the general population
Holo-transcobalamin is not associated with the risk of all-cause mortality in the general population Open
The biologically active form of vitamin B12, holo-TC, is not related to the risk of all-cause mortality in a moderate-sized sample from the general population.
View article: Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster
Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster Open
The amount of dietary sugars and the administration of lithium both impact the lifespan of the fruit fly Drosophila melanogaster. It is noteworthy that lithium is attributed with insulin-like activity as it stimulates protein kinase…
View article: Stearidonic acid improves eicosapentaenoic acid status: studies in humans and cultured hepatocytes
Stearidonic acid improves eicosapentaenoic acid status: studies in humans and cultured hepatocytes Open
Background Ahiflower oil from the seeds of Buglossoides arvensis is rich in α-linolenic acid (ALA) and stearidonic acid (SDA). ALA and SDA are potential precursor fatty acids for the endogenous synthesis of eicosapentaenoic acid (EPA) and …
View article: In vitro and in silico studies reveal antidiabetic properties of arylbenzofurans from the root bark of Morus mesozygia Stapf
In vitro and in silico studies reveal antidiabetic properties of arylbenzofurans from the root bark of Morus mesozygia Stapf Open
Diabetes remains an important disease worldwide with about 500 million patients globally. In tropical Africa, Morus mesozygia is traditionally used in the treatment of diabetes. Biological and phytochemical investigation of the root bark e…
View article: High-Dose Polyphenol-Rich Nutrition Improves Lipid and Inflammation Profiles and Can Trigger Apoptotic Signaling in Healthy Older Adults (the ErdBEHR Study)
High-Dose Polyphenol-Rich Nutrition Improves Lipid and Inflammation Profiles and Can Trigger Apoptotic Signaling in Healthy Older Adults (the ErdBEHR Study) Open
A high-dose polyphenol-rich nutrition decreases LDL and CRP levels in healthy older adults, and at highest dose, gene expression data highlight "positive regulation of apoptotic signaling".• Top: Study design, escalating the intervention p…
View article: Urinary vanin-1, tubular injury, and graft failure in kidney transplant recipients
Urinary vanin-1, tubular injury, and graft failure in kidney transplant recipients Open
View article: Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3
Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3 Open
Recent genome- and exome-wide association studies suggest that the human APOE ε4 allele protects against non-alcoholic fatty liver disease (NAFLD), while ε3 promotes hepatic steatosis and steatohepatitis. The present study aimed at examini…
View article: Lithium Affects Sodium Balance But Not Intestinal Microbiota - Studies in Drosophila Melanogaster
Lithium Affects Sodium Balance But Not Intestinal Microbiota - Studies in Drosophila Melanogaster Open
View article: Association of Plasma Zinc and Copper with Body Composition, Lipids and Inflammation in a Cross-Sectional General Population Sample from Germany
Association of Plasma Zinc and Copper with Body Composition, Lipids and Inflammation in a Cross-Sectional General Population Sample from Germany Open
We aimed to relate circulating plasma zinc and copper to a broad spectrum of adiposity-related traits in a cross-sectional Northern German study (n = 841, 42% female, age: 61 ± 12 years). Zinc and copper were measured by inductively couple…
View article: Dietary lithium stimulates female fecundity in <i>Drosophila melanogaster</i>
Dietary lithium stimulates female fecundity in <i>Drosophila melanogaster</i> Open
The trace element lithium exerts a versatile bioactivity in humans, to some extend overlapping with in vivo findings in the model organism Drosophila melanogaster . A potentially essential function of lithium in reproduction has been sugge…
View article: Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease—What are the proposed mechanisms?
Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease—What are the proposed mechanisms? Open
A high consumption of ultra-processed food (UPF) is a hallmark of Western diets that has been related to increased risk of non-communicable diseases. As an underlying mechanism, UPF may promote non-alcoholic fatty liver disease (NAFLD) whi…
View article: Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of <scp><i>D. melanogaster</i></scp>
Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of <span><i>D. melanogaster</i></span> Open
Recent reports indicated that the phytochemical curcumin possesses iron‐chelating activity. Here, by employing the fruit fly Drosophila melanogaster , we conducted feeding studies supplementing curcumin or, as a control, the iron chelator …
View article: High-dose Polyphenol-rich Nutrition Improves Lipid and Inflammation Profiles and Triggers Apoptotic Signaling in Healthy Elderly People (the ErdBEHR Study)
High-dose Polyphenol-rich Nutrition Improves Lipid and Inflammation Profiles and Triggers Apoptotic Signaling in Healthy Elderly People (the ErdBEHR Study) Open
Nutritional interventions in healthy individuals may be particularly informative if high, but not excessive, amounts of specific healthy foods are taken to maximize effects without sacrificing safety. We hypothesized that high amounts of p…
View article: Soy Extract, Rich in Hydroxylated Isoflavones, Exhibits Antidiabetic Properties In Vitro and in Drosophila melanogaster In Vivo
Soy Extract, Rich in Hydroxylated Isoflavones, Exhibits Antidiabetic Properties In Vitro and in Drosophila melanogaster In Vivo Open
In the context of the growing prevalence of type 2 diabetes (T2DM), control of postprandial hyperglycemia is crucial for its prevention. Blood glucose levels are determined by various factors including carbohydrate hydrolyzing enzymes, the…
View article: Low selenium intake is associated with risk of all-cause mortality in kidney transplant recipients
Low selenium intake is associated with risk of all-cause mortality in kidney transplant recipients Open
Background Deficiency of the essential trace element selenium is common in kidney transplant recipients (KTR), potentially hampering antioxidant and anti-inflammatory defence. Whether this impacts the long-term outcomes of KTR remains unkn…
View article: Plasma Copper Concentration Is Associated with Cardiovascular Mortality in Male Kidney Transplant Recipients
Plasma Copper Concentration Is Associated with Cardiovascular Mortality in Male Kidney Transplant Recipients Open
Kidney transplant recipients (KTR) are at increased risk of cardiovascular mortality. We investigated whether, in KTR, post-transplantation copper status is associated with the risk of cardiovascular mortality and potential effect modifica…
View article: The mitochondrial BCKD complex interacts with hepatic apolipoprotein E in cultured cells in vitro and mouse livers in vivo
The mitochondrial BCKD complex interacts with hepatic apolipoprotein E in cultured cells in vitro and mouse livers in vivo Open
View article: Urinary Copper Excretion Is Associated with Long-Term Graft Failure in Kidney Transplant Recipients
Urinary Copper Excretion Is Associated with Long-Term Graft Failure in Kidney Transplant Recipients Open
Introduction: In chronic kidney disease, proteinuria increases urinary copper excretion, inducing oxidative tubular damage and worsening kidney function. We investigated whether this phenomenon occurred in kidney transplant recipients (KTR…