Gerald Yu Liao
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View article: Reply to the Letter on “Sample Size and Wearable Adherence Impact on Postoperative Sleep Assessment in Total Joint Arthroplasty”
Reply to the Letter on “Sample Size and Wearable Adherence Impact on Postoperative Sleep Assessment in Total Joint Arthroplasty” Open
View article: The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets
The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets Open
The house cricket ( Acheta domesticus ) is a promising preclinical geroscience model due to its short lifespan, low maintenance, age-associated functional decline, and responsiveness to geroprotective drugs. Continuous dosing with rapamyci…
View article: Age-related cognitive decline in house crickets reveals conserved patterns of sensory and learning deficits across the lifespan
Age-related cognitive decline in house crickets reveals conserved patterns of sensory and learning deficits across the lifespan Open
Cognitive decline with age is characterized by impairments in learning, sensory discrimination, and decision-making. While mammalian models have advanced understanding of the neural substrates of aging, their use in large-scale behavioral …
View article: Morphological features of the domestic house cricket (Acheta domesticus) for translational aging studies
Morphological features of the domestic house cricket (Acheta domesticus) for translational aging studies Open
Aging alters morphology and locomotor function in diverse organisms, yet standardized model systems for studying these changes remain limited to a relatively few species. Here, we present a comprehensive analysis of age- and sex-dependent …
View article: Morphological features of the domestic house cricket ( <i>Acheta domesticus</i> ) for translational aging studies
Morphological features of the domestic house cricket ( <i>Acheta domesticus</i> ) for translational aging studies Open
Aging alters morphology and locomotor function in diverse organisms, yet standardized model systems for studying these changes remain limited to a relatively few species. Here, we present a comprehensive analysis of age- and sex-dependent …
View article: Comparison of age-related decline in C57BL/6J and CB6F1J male mice
Comparison of age-related decline in C57BL/6J and CB6F1J male mice Open
Variability in physical resilience to aging prompts a comprehensive examination of underlying mechanisms across organs and individuals. We conducted a detailed exploration of behavioral and physiological differences between male C57BL/6J a…
View article: THE INSECT ACHETA DOMESTICUS IS A PROMISING MODEL FOR AGING AND AGING INTERVENTION STUDIES
THE INSECT ACHETA DOMESTICUS IS A PROMISING MODEL FOR AGING AND AGING INTERVENTION STUDIES Open
A number of animal species are being used as models to study aging and age-related diseases. They have varying advantages such as shorter lifespan, relatively low costs, and full access to internal organs. While no single model can replica…
View article: Behavioral and neuropathological features of Alzheimer’s disease are attenuated in 5xFAD mice treated with intranasal GHK peptide
Behavioral and neuropathological features of Alzheimer’s disease are attenuated in 5xFAD mice treated with intranasal GHK peptide Open
Alzheimer's disease (AD) is a complex neurodegenerative disease and a leading cause of morbidity and mortality. Efforts to find disease modifying treatments have met with limited success. The naturally occurring peptide GHK (glycyl-L-histi…
View article: Comparison of Age-Related Decline and Behavioral Validity in C57BL/6 and CB6F1 Mice
Comparison of Age-Related Decline and Behavioral Validity in C57BL/6 and CB6F1 Mice Open
Variability in physical resilience to aging prompts a comprehensive examination of underlying mechanisms across organs and individuals. We conducted a detailed exploration of behavioral and physiological differences between C57BL/6 and CB6…
View article: Exploring the complex interplay between anxiety, aging, and behavior in CB6F1 and C57BL/6 mice: Implications for cognitive function
Exploring the complex interplay between anxiety, aging, and behavior in CB6F1 and C57BL/6 mice: Implications for cognitive function Open
Anxiety is a pervasive emotional response that can profoundly impact well-being and cognitive function in both humans and animals. The relationship between anxiety and aging remains complex and multifaceted. To explore this relationship in…
View article: The House Cricket is an unrecognized but potentially powerful model for aging intervention studies
The House Cricket is an unrecognized but potentially powerful model for aging intervention studies Open
Human-based research on the biology of aging poses challenges due to ethical, social, and cost considerations. Animal models offer a pragmatic alternative, although no single model fully replicates all aspects of human aging. One unexplore…
View article: Behavioral and neuropathological features of Alzheimer’s disease are attenuated in 5xFAD mice treated with intranasal GHK peptide
Behavioral and neuropathological features of Alzheimer’s disease are attenuated in 5xFAD mice treated with intranasal GHK peptide Open
Efforts to find disease modifying treatments for Alzheimer’s disease (AD) have met with limited success in part because the focus has been on testing drugs that target a specific pathogenic mechanism. Multiple pathways have been implicated…
View article: Importance of Substrate–Particle Repulsion for Protein-Templated Assembly of Metal Nanoparticles
Importance of Substrate–Particle Repulsion for Protein-Templated Assembly of Metal Nanoparticles Open
We study the protein-directed assembly of colloidal gold nanoparticles on de novo designed protein nanofiber templates. Using sequential assembly on glass substrates, we attach positively charged gold nanoparticles to protein nanofi…