Géraldine Gelders
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View article: Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradation
Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradation Open
Targeted protein degradation (TPD) has emerged as a highly promising therapeutic strategy for a wide range of diseases, including cancer and neurodegenerative disorders. The ubiquitin-proteasome system, which is responsible for protein deg…
View article: Targeted degradation of α-synuclein prevents PFF-induced aggregation
Targeted degradation of α-synuclein prevents PFF-induced aggregation Open
Accumulation of misfolded α-synuclein protein in intracellular inclusion bodies of dopaminergic neurons underlies the pathogenesis of Synucleinopathies, which include Parkinson’s Disease (PD), Dementia with Lewy Bodies (DLB) and Multiple S…
View article: Targeted degradation of a‐synuclein via the AdPROM system prevents PFF‐induced a‐synuclein aggregation
Targeted degradation of a‐synuclein via the AdPROM system prevents PFF‐induced a‐synuclein aggregation Open
Background Accumulation of misfolded a‐synuclein protein in intracellular inclusion bodies of dopaminergic neurons underlies the pathogenesis of synucleinopathies, which include Parkinson’s Disease (PD), Dementia with Lewy Bodies (DLB) and…
View article: Host oligodendrogliopathy and α-synuclein strains dictate disease severity in multiple system atrophy
Host oligodendrogliopathy and α-synuclein strains dictate disease severity in multiple system atrophy Open
Multiple system atrophy is a progressive neurodegenerative disease with prominent autonomic and motor features. During early stages, different subtypes of the disease are distinguished by their predominant parkinsonian or cerebellar sympto…
View article: LRRK2 Ablation Attenuates Alpha-Synuclein–Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo
LRRK2 Ablation Attenuates Alpha-Synuclein–Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo Open
View article: The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research Open
View article: The<i>App</i><sup><i>NL-G-F</i></sup>mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
The<i>App</i><sup><i>NL-G-F</i></sup>mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research Open
In this study, we report the results of a comprehensive phenotyping of the retina of the App NL-G-F mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formati…
View article: The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies Open
View article: Mutated ATP10B increases Parkinson’s disease risk by compromising lysosomal glucosylceramide export
Mutated ATP10B increases Parkinson’s disease risk by compromising lysosomal glucosylceramide export Open
View article: ATP13A2 deficiency disrupts lysosomal polyamine export
ATP13A2 deficiency disrupts lysosomal polyamine export Open
View article: In vivo characterization of distinct patient-derived alpha-synuclein strains
In vivo characterization of distinct patient-derived alpha-synuclein strains Open
Event Abstract Back to Event In vivo characterization of distinct patient-derived alpha-synuclein strains Géraldine Gelders1*, Anke Van Der Perren1*, Filipa De Brito1, Wouter Peelaerts1 and Veerle Baekelandt1 1 Department of Neurosciences,…
View article: The role of LRRK2 inhibition in α-synuclein-induced neurotoxicity and neuroinflammation in vivo.
The role of LRRK2 inhibition in α-synuclein-induced neurotoxicity and neuroinflammation in vivo. Open
Event Abstract Back to Event The role of LRRK2 inhibition in α-synuclein-induced neurotoxicity and neuroinflammation in vivo. Diego Cabezudo1*, Anke Van Der Perren1, Géraldine Gelders1, Chris Van Den Haute1, Veerle Baekelandt1 and Evy Lobb…
View article: Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease Open
Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society. Misfolded protein aggregates are a critical aspect of several neurodegenerat…
View article: Targeting Neuroinflammation to Treat Alzheimer’s Disease
Targeting Neuroinflammation to Treat Alzheimer’s Disease Open
View article: Targeting Neuroinflammation to Treat Alzheimer's Disease
Targeting Neuroinflammation to Treat Alzheimer's Disease Open
Over the past few decades, research on Alzheimer's disease (AD) has focused on pathomechanisms linked to two of the major pathological hallmarks of extracellular deposition of beta-amyloid peptides and intra-neuronal formation of neurofibr…
View article: In vivo characterization of different alpha-synuclein variants
In vivo characterization of different alpha-synuclein variants Open
Event Abstract Back to Event In vivo characterization of different alpha-synuclein variants Anke Van Der Perren1*, Géraldine Gelders1, Nikol Shakhbazyan1, Francesca Macchi1, Chris Van Den Haute1, 2 and Veerle Baekelandt1, 2 1 KU Leuven, N…
View article: Differential response of microglia to distinct alpha-synuclein assemblies
Differential response of microglia to distinct alpha-synuclein assemblies Open
Event Abstract Back to Event Differential response of microglia to distinct alpha-synuclein assemblies Anke Van Der Perren1*, Géraldine Gelders1, Francesca Macchi1, Wouter Peelaerts1, Luc Bousset2, Chris Van Den Haute1, Ronald Melki2 and V…