Géralyn C. Trudel
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View article: 1061. Evaluation of Measures for the Assessment of Covid-19 Signs and Symptoms in Children and Adolescents
1061. Evaluation of Measures for the Assessment of Covid-19 Signs and Symptoms in Children and Adolescents Open
Background The Symptoms of Infection with Coronavirus-19 (SIC) is a 30-item patient-reported outcome (PRO) measure developed to assess the presence and severity of COVID-19 signs and symptoms in adults. To further facilitate the evaluation…
View article: Interim results of a phase Ib study of niraparib plus androgen receptor-targeted therapy in men with metastatic castration-resistant prostate cancer
Interim results of a phase Ib study of niraparib plus androgen receptor-targeted therapy in men with metastatic castration-resistant prostate cancer Open
Background: Niraparib is a potent inhibitor of poly (ADP-ribose) polymerase (PARP)-1 and PARP-2, enzymes involved in DNA repair. PARP-1 is involved in modulating androgen receptor (AR) signaling and function. A phase 1b study (Bedivere) of…
View article: Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer
Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer Open
Among men with nonmetastatic castration-resistant prostate cancer, metastasis-free survival and time to symptomatic progression were significantly longer with apalutamide than with placebo. (Funded by Janssen Research and Development; SPAR…
View article: The Direct Healthcare Expenditures of Prostate Cancer by Disease Severity: Evidence from US National Survey Data
The Direct Healthcare Expenditures of Prostate Cancer by Disease Severity: Evidence from US National Survey Data Open
Background: In the United States, approximately 2.8 million men have a history of prostate cancer (PC). Objective: This study quantified the effects of PC, overall and by disease severity on direct healthcare costs to insurers and patients…