Gerard Arrey Tané
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Atlas of eccDNA in Mus musculus reveals intron and isoform gene-density dependent protection of transcription-induced eccDNA formation Open
EccDNA is a driver of many cancers and a potential intermediate in other age-related disorders. However, little is known about the mechanisms underlying eccDNA formation in healthy tissue and how age affects these processes. We generated a…
Did circular DNA shape the evolution of mammalian genomes? Open
Extrachromosomal circular DNA of chromosomal origin (eccDNA) can rapidly shape the evolution and adaptation of mitotically dividing cells such as tumor cells. However, whether eccDNA has a permanent impact on genome evolution through the g…