Gerard Callejo
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View article: Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience
Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience Open
The pressing need for safer, more efficacious analgesics is felt worldwide. Preclinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before consideration for human…
View article: TRESK background potassium channel in MrgprA3<sup>+</sup>pruriceptors regulates acute and chronic itch
TRESK background potassium channel in MrgprA3<sup>+</sup>pruriceptors regulates acute and chronic itch Open
TRESK (K2P18.1) is a background K + channel expressed in sensory neurons, where it modulates the resting membrane potential, action potential firing and neuronal excitability. A subset of these sensory neurons, which express specific TRPs …
View article: TRESK CHANNEL MODULATES CA3 PYRAMIDAL NEURONS’ EXCITABILITY AND HIPPOCAMPAL SYNAPTIC PLASTICITY
TRESK CHANNEL MODULATES CA3 PYRAMIDAL NEURONS’ EXCITABILITY AND HIPPOCAMPAL SYNAPTIC PLASTICITY Open
View article: INCREASED SENSORY NEURON EXCITABILITY BY TRESK CHANNEL ABSENCE ENHANCES ACUTE AND CHRONIC ITCH.
INCREASED SENSORY NEURON EXCITABILITY BY TRESK CHANNEL ABSENCE ENHANCES ACUTE AND CHRONIC ITCH. Open
View article: Digging deeper into pain – an ethological behavior assay correlating well-being in mice with human pain experience
Digging deeper into pain – an ethological behavior assay correlating well-being in mice with human pain experience Open
The pressing need for safer, more efficacious analgesics is felt worldwide. Pre-clinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before consideration for huma…
View article: A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals Open
View article: Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors
Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors Open
Prdm12 is a conserved epigenetic transcriptional regulator that displays restricted expression in nociceptors of the developing peripheral nervous system. In mice, Prdm12 is required for the development of the entire nociceptive lineage. I…
View article: Proton Sensing on the Ocular Surface: Implications in Eye Pain
Proton Sensing on the Ocular Surface: Implications in Eye Pain Open
Protons reaching the eyeball from exogenous acidic substances or released from damaged cells during inflammation, immune cells, after tissue injury or during chronic ophthalmic conditions, activate or modulate ion channels present in senso…
View article: The Background K+ Channel TRESK in Sensory Physiology and Pain
The Background K+ Channel TRESK in Sensory Physiology and Pain Open
TRESK belongs to the K2P family of potassium channels, also known as background or leak potassium channels due to their biophysical properties and their role regulating membrane potential of cells. Several studies to date have highlighted …
View article: Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit
Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit Open
View article: Intraarticular Adeno‐Associated Virus Serotype AAV‐PHP.S–Mediated Chemogenetic Targeting of Knee‐Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice
Intraarticular Adeno‐Associated Virus Serotype AAV‐PHP.S–Mediated Chemogenetic Targeting of Knee‐Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice Open
Objective Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee‐innervating dorsal root ganglion ( DRG ) neurons (knee neurons) could potentially provide pain relief. We…
View article: Data to support: Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice
Data to support: Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice Open
The files contain the raw data to support the publication and are organised into separate files, each one corresponding to a different figure in the paper.\n\nAlongside the raw data, the statistical analyses used in the published paper are…
View article: Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain
Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain Open
Pain is a principal contributor to the global burden of arthritis with peripheral sensitization being a major cause of arthritis-related pain. Within the knee joint, distal endings of dorsal root ganglion neurons (knee neurons) interact wi…
View article: Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice
Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice Open
Objective Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee-innervating dorsal root ganglion (DRG) neurons (knee neurons) could potentially provide pain relief. Ther…
View article: In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3
In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3 Open
Acid-sensing ion channels (ASICs) are voltage-independent cation channels that detect decreases in extracellular pH. Dysregulation of ASICs underpins a number of pathologies. Of particular interest is ASIC3, which is recognised as a key se…
View article: TRESK background K <sup>+</sup> channel deletion selectively uncovers enhanced mechanical and cold sensitivity
TRESK background K <sup>+</sup> channel deletion selectively uncovers enhanced mechanical and cold sensitivity Open
Key points TRESK background K + channel is expressed in sensory neurons and acts as a brake to reduce neuronal activation. Deletion of the channel enhances the excitability of nociceptors. Skin nociceptive C‐fibres show an enhanced activat…
View article: Human Labour Pain is Influenced by the Voltage-Gated Potassium Channel K <sub>v</sub>6.4 Subunit
Human Labour Pain is Influenced by the Voltage-Gated Potassium Channel K <sub>v</sub>6.4 Subunit Open
View article: Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves
Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves Open
Acid sensing in the gastrointestinal tract is required for gut homeostasis and the detection of tissue acidosis caused by ischaemia, inflammation and infection. In the colorectum, activation of colonic afferents by low pH contributes to vi…
View article: Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain
Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain Open
Pain is a principal contributor to the global burden of arthritis with peripheral sensitization being a major cause of arthritis-related pain. Within the knee joint, distal endings of dorsal root ganglion neurons (knee neurons) interact wi…
View article: Evolution of acid nociception: ion channels and receptors for detecting acid
Evolution of acid nociception: ion channels and receptors for detecting acid Open
Nociceptors, i.e. sensory neurons tuned to detect noxious stimuli, are found in numerous phyla of the Animalia kingdom and are often polymodal, responding to a variety of stimuli, e.g. heat, cold, pressure and chemicals, such as acid. Owin…
View article: <i>In silico</i> screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3
<i>In silico</i> screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3 Open
Acid-sensing ion channels (ASICs) are voltage-independent cation channels that detect decreases in extracellular pH. Dysregulation of ASICs underpins a number of pathologies. Of particular interest is ASIC3, which is recognised as a key se…
View article: Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves
Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves Open
Acid sensing in the gastrointestinal tract is required for gut homeostasis and the detection of tissue acidosis caused by ischaemia, inflammation and infection. In the colorectum, activation of colonic afferents by low pH contributes to vi…
View article: TRESK background K<sup>+</sup> channel deletion selectively uncovers enhanced mechanical and cold sensitivity
TRESK background K<sup>+</sup> channel deletion selectively uncovers enhanced mechanical and cold sensitivity Open
Changes in TRESK K + channel expression/function enhance sensory neurons excitability, but its role in somatosensory perception and nociception is poorly understood. We show that TRESK regulates the sensitivity to mechanical and cold stimu…
View article: Human labour pain is influenced by the voltage-gated potassium channel K<sub>V</sub>6.4 subunit
Human labour pain is influenced by the voltage-gated potassium channel K<sub>V</sub>6.4 subunit Open
A bstract We sought genetic effects on labour pain by studying healthy women who did not request analgesia during their first delivery. Extensive sensory and psychometric testing were normal in these women, except for significantly higher …
View article: Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner Open
View article: Data to support: Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner
Data to support: Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner Open
View article: Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner Open
Ongoing, spontaneous pain is characteristic of inflammatory joint pain and reduces an individual’s quality of life. To understand the neural basis of inflammatory joint pain, we made a unilateral knee injection of complete Freund’s adjuvan…
View article: Single-cell RNAseq reveals seven classes of colonic sensory neuron
Single-cell RNAseq reveals seven classes of colonic sensory neuron Open
Objective Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and give rise to conscious sensation, but …
View article: Increased hyperpolarized [1‐<sup>13</sup>C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized <sup>13</sup>C‐labelled bicarbonate
Increased hyperpolarized [1‐<sup>13</sup>C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized <sup>13</sup>C‐labelled bicarbonate Open
Arthritic conditions are a major source of chronic pain. Furthering our understanding of disease mechanisms creates the opportunity to develop more targeted therapeutics. In rheumatoid arthritis (RA), measurements of pH in human synovial f…
View article: Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers
Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers Open