Explanipedia

Chemokine receptor expression defines a trajectory from monocytes to mature macrophages Open

Heather Matthie, Laura Medina‐Ruiz, Fabian Schuette, Heba A. Halawa, Zuzanna Pocalun , et al. · 2025

CCR1, CCR2 and CCR5 direct recruitment of monocytes and macrophages in inflammation. However, the discrete role for each receptor in monocyte/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. U…

Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation Open

Robin Bartolini, Deepika Sharma, Gillian Wilson, Gillian Dunphy, Jonathan Cavanagh , et al. · 2025

Adaptive immune responses are intensely energy-dependent and rely on a local source of fuel-producing molecules which have been proposed to be derived from fat pads in which mammalian lymph nodes are embedded. However, the trigger for thei…

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Open

Nabina Pun, Urszula Cytlak, Dave Lee, Rita G. Domingues, Eleanor J. Cheadle , et al. · 2025

Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is …

Chemokine receptors in GtoPdb v.2025.3 Open

Françoise Bachelerie, Philip M. Murphy, Robert J. B. Nibbs, Hisayuki Nomiyama, Joost J. Oppenheim , et al. · 2025

Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [460, 459, 32, 125]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically …

Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza Open

Marieke Pingen, Catherine E. Hughes, Laura Medina‐Ruiz, Heather Mathie, Jennifer A. Barrie , et al. · 2025

Inflammatory chemokine receptors CCR1/2/3/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here we utilise an influenza A virus (IAV) ch…

Chemokine receptors in GtoPdb v.2025.1 Open

Françoise Bachelerie, Philip M. Murphy, Robert J. B. Nibbs, Hisayuki Nomiyama, Joost J. Oppenheim , et al. · 2025

Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [459, 458, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically posse…

Eosinophils promote monocyte to macrophage differentiation and anti-bacterial immunity Open

Gillian Wilson, Lily Koumbas Foley, Zuzanna Pocalun, Elise Pitmon, Ayumi Fukuoka , et al. · 2024

Chemokine receptors control cell migration within the body. Here we reveal a novel interaction between eosinophils and monocytes in the bone marrow, indirectly controlled by the atypical chemokine receptor ACKR2. We demonstrate that ACKR2 …

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Open

Nabina Pun, Urszula Cytlak, Dave Lee, Rita G. Domingues, Eleanor J. Cheadle , et al. · 2024

Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is …

Enhanced CCR2 expression by ACKR2-deficient NK cells increases tumoricidal cell therapy efficacy Open

Alan J. Hayes, Marieke Pingen, Gillian Wilson, Chris Hansell, Samantha Love , et al. · 2024

Chemokines regulate leukocyte navigation to inflamed sites and specific tissue locales and may therefore be useful for ensuring accurate homing of cell therapeutic products. We, and others, have shown that atypical chemokine receptor 2 (AC…

EBV T-cell immunotherapy generated by peptide selection has enhanced effector functionality compared to LCL stimulation Open

Rachel Cooper, Catherine Sutherland, Linda Smith, Graeme Cowan, Mark Barnett , et al. · 2024

Adoptive immunotherapy with Epstein–Barr virus (EBV)-specific T cells is an effective treatment for relapsed or refractory EBV-induced post-transplant lymphoproliferative disorders (PTLD) with overall survival rates of up to 69%. EBV-speci…

CCR1 and CCR2 Coexpression on Monocytes Is Nonredundant and Delineates a Distinct Monocyte Subpopulation Open

Laura Medina‐Ruiz, Robin Bartolini, Heather Mathie, Heba A. Halawa, Madeleine E. Cunningham , et al. · 2024

The interactions between chemokines and their receptors, particularly in the context of inflammation, are complex, with individual receptors binding multiple ligands and individual ligands interacting with multiple receptors. In addition, …

IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors Open

Robert Wiesheu, Sarah C. Edwards, A J Hedley, H. G. HALL, Marie Tosolini , et al. · 2024

In mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the periphery, these cells play a critical role in host defense and anti-tumor immunity. Un…

The people behind the papers – Ayumi Fukuoka and Gerry Graham Open

Gerard J. Graham · 2024

Chemokines are perhaps best known for their role in immune responses, but they can also regulate cell migration during embryonic development. A new paper in Development shows that an atypical chemokine receptor sequesters maternal CXCL12 i…

Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring Open

Ayumi Fukuoka, Gillian Wilson, Elise Pitmon, Lily Koumbas Foley, Hanna Johnsson , et al. · 2024

ACKR3 scavenges and degrades the stem cell recruiting chemokine CXCL12, which is essential for proper embryonic and, in particular, haematopoietic development. Here, we demonstrate strong expression of ACKR3 on trophoblasts. Using a matern…

Global deficiency in the inflammatory chemokine receptors 1,2,3 and 5 ameliorates atherosclerosis and selectively modulates aortic myeloid cell phenotype Open

Neil MacRitchie, Maryam Shoaran, Danila Gurgone, Song Gu, Lucy McShane , et al. · 2023

Background Atherosclerosis is a chronic inflammatory disease in which leukocytes traffic to the vessel wall, a process in part mediated by the inflammatory chemokine receptors (iCCRs): Ccr1, Ccr2, Ccr3 and Ccr5. ICCRs display significant l…

IL-27 maintains cytotoxic Ly6C <sup>+</sup> γδ T cells that arise from immature precursors Open

Robert Wiesheu, Sarah C. Edwards, Ann Hedley, Marie Tosolini, Marcelo Gregorio Filho Fares da Silva , et al. · 2023

In mice, γδ T cells that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage in the thymus, and in the periphery, these cells play a critical role in host defence and anti-tumor immunity. Unlike αβ T cell…

Macrophage reprogramming—rather than depletion—is efficacious in a specific subset of colorectal tumor models Open

Noha-Ehssan Mohamed, Raheleh Amirkhah, Xabier-Cortes Lavaud, Kathryn Gilroy, Robin Bartolini , et al. · 2023

Despite the abundance of macrophages in colorectal cancer (CRC), macrophage-targeted therapy has not demonstrated significant clinical benefit. Here, we show that macrophage populations differ across the consensus molecular subtypes (CMS) …

Disruption of maternal ACKR3 has profound effects on embryos and offspring Open

Ayumi Fukuoka, Gillian Wilson, Elise Pitmon, Lily Koumbas Foley, Hanna Johnsson , et al. · 2023

ACKR3, scavenges and degrades the stem cell recruiting chemokine CXCL12 which is essential for proper embryonic, and in particular hematopoietic, development. Here we demonstrate strong expression of ACKR3 on trophoblasts. Using a pharmaco…

IL-6 and TGF-β-Secreting Adoptively-Transferred Murine Mesenchymal Stromal Cells Accelerate Healing of Psoriasis-like Skin Inflammation and Upregulate IL-17A and TGF-β Open

Nerea Cuesta‐Gomez, Laura Medina‐Ruiz, Gerard J. Graham, John Campbell · 2023

Mesenchymal stromal cells (MSC) show promise as cellular therapeutics. Psoriasis is a chronic inflammatory disease affecting the skin and the joints. Injury, trauma, infection and medications can trigger psoriasis by disrupting epidermal k…

Differences in transcriptional changes in psoriasis and psoriatic arthritis skin with immunoglobulin gene enrichment in psoriatic arthritis Open

Hanna Johnsson, John Cole, Iain B. McInnes, Gerard J. Graham, Stefan Siebert · 2023

Objectives Approximately 20% of people with psoriasis develop PsA. Although genetic, clinical and environmental risk factors have been identified, it is not known why some people with psoriasis develop PsA. The skin disease is traditionall…

Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways Open

Hanna Johnsson, John Cole, Stefan Siebert, Iain B. McInnes, Gerard J. Graham · 2023

Chemokine receptors in GtoPdb v.2023.1 Open

Françoise Bachelerie, Adit Ben‐Baruch, Amanda M. Burkhardt, Israel Charo, Christophe Combadière , et al. · 2023

Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [438, 437, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically posse…

Additional file 3 of Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways Open

Hanna Johnsson, John Cole, Stefan Siebert, Iain B. McInnes, Gerard J. Graham · 2023

Additional file 3. Differentially expressed genes in the GO Keratinization gene set. Boxplots of DEGs (padj <0.05, absolute log2fold >1) which form part of the GO Keratinization gene set when PsA skin lesions (PsA L) were compared to healt…

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors Open

Anna L. Gray, Richard Karlsson, Abigail R. E. Roberts, Amanda J. L. Ridley, Nabina Pun , et al. · 2023

Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflamma…

Placental Inflammation Leads to Abnormal Embryonic Heart Development Open

Eleanor J. Ward, Serena Bert, Silvia Fanti, Kerri M. Malone, Robert T. Maughan , et al. · 2022

Background: Placental heart development and embryonic heart development occur in parallel, and these organs have been proposed to exert reciprocal regulation during gestation. Poor placentation has been associated with congenital heart dis…

The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis Open

Tian Yu, Fabian Schuette, Maria Christofi, John V. Forrester, Gerard J. Graham , et al. · 2022

Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population. Inflammation in HSK is chemokine-dependent, particularly CXCL10 and less so …

Inflammatory Chemokine Receptors Support Inflammatory Macrophage and Dendritic Cell Maturation Open

Robin Bartolini, Laura Medina‐Ruiz, Alan J. Hayes, Christopher J. Kelly, Heba A. Halawa , et al. · 2022

Dendritic cells form clusters in vivo, but the mechanism behind this has not been determined. In this article, we demonstrate that monocytes from mice deficient in the chemokine receptors CCR1, CCR2, CCR3, and CCR5 display reduced clusteri…

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment Open

Anna L. Gray, Richard Karlsson, Abigail R. E. Roberts, Amanda J. L. Ridley, Nabina Pun , et al. · 2022

Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system, but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflamm…

Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice Open

Laura Medina‐Ruiz, Robin Bartolini, Gillian Wilson, Douglas P. Dyer, Francesca Vidler , et al. · 2022

Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how ch…

CXCR2 inhibition enables NASH-HCC immunotherapy Open

Jack Leslie, John B. G. Mackey, Thomas Jamieson, Erik Ramon‐Gil, Thomas M. Drake , et al. · 2022

Objective Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data suggests NASH-HCC may be less sensitive to conventional immune chec…

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