Gerben E. Breimer
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View article: Head-to-Head Comparison of 2 Artificial Intelligence Tools for Detecting Lymph Node Metastases in Whole-Slide Pathology Images Within and Beyond Their Intended Use
Head-to-Head Comparison of 2 Artificial Intelligence Tools for Detecting Lymph Node Metastases in Whole-Slide Pathology Images Within and Beyond Their Intended Use Open
The increasing diagnostic workload in pathology, driven by rising cancer incidences, highlights the need for scalable, cost effective solutions. Artificial intelligence (AI) has shown promise in supporting lymph node (LN) metastasis detect…
View article: Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities
Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities Open
The tongue is essential for swallowing, taste perception, and mechanosensation. The anterior and posterior parts of the tongue have region‐specific developmental origins and are maintained by adult epithelial stem/progenitor cells. In vitr…
View article: ALK-positive histiocytosis and a clonally related chronic myelomonocytic leukemia
ALK-positive histiocytosis and a clonally related chronic myelomonocytic leukemia Open
Not available.
View article: Cemento-osseous dysplasia with a NOTCH4 mutation: a case report
Cemento-osseous dysplasia with a NOTCH4 mutation: a case report Open
Cemento-osseous dysplasia (COD) is a benign fibro-osseous lesion of the jaw that can mimic other entities, particularly cemento-ossifying fibroma (COF), both radiologically and histologically. Although recent research has implicated mutati…
View article: Head and Neck Cancer in Suriname: An Epidemiologic Review of Clinical and Pathologic Features of Patients Treated Between 2009 and 2021
Head and Neck Cancer in Suriname: An Epidemiologic Review of Clinical and Pathologic Features of Patients Treated Between 2009 and 2021 Open
PURPOSE This study investigates the incidence and clinicopathologic characteristics of head and neck cancer (HNC) in the Surinamese population, with an emphasis on the burden of human papillomavirus (HPV) and Epstein-Barr virus (EBV). METH…
View article: Expanding the spectrum of AFF2 carcinoma: clinical, morphological, immunohistochemical, and molecular characteristics of five cases harboring alternate fusions
Expanding the spectrum of AFF2 carcinoma: clinical, morphological, immunohistochemical, and molecular characteristics of five cases harboring alternate fusions Open
In recent years, multiple molecularly defined entities have emerged in head and neck pathology, especially among sinonasal squamous and basaloid carcinomas, including NUT carcinoma, SWI/SNF-deficient carcinoma, and DEK :: AFF2 carcinoma. T…
View article: Cemento-Osseous Dysplasia With a NOTCH4 Mutation: a Case Report
Cemento-Osseous Dysplasia With a NOTCH4 Mutation: a Case Report Open
Purpose Cemento-osseous dysplasia (COD) is a benign fibro-osseous lesion of the jaw that poses diagnostic challenges due to overlapping features with other entities, particularly cemento-ossifying fibroma (COF). While recent studies have i…
View article: AI-detected tumor-infiltrating lymphocytes for predicting outcomes in anti-PD1 based treated melanoma
AI-detected tumor-infiltrating lymphocytes for predicting outcomes in anti-PD1 based treated melanoma Open
Importance Easy and accessible biomarkers to predict response to immune checkpoint inhibition (ICI)-treated melanoma are limited. Objective To evaluate artificial intelligence (AI) detected tumor-infiltrating lymphocytes (TILs) on pretreat…
View article: Evaluating the performance of LYDIA: an AI-powered assistant in detection of metastatic tumors in lymph nodes
Evaluating the performance of LYDIA: an AI-powered assistant in detection of metastatic tumors in lymph nodes Open
The integration of AI in histopathology represents a significant advancement in diagnosing metastatic cancers. LYDIA ( LY mph no D e ass I st A nt) is a commercially available AI-powered tool designed to annotate tumors in lymph node secti…
View article: Recurrent MDM2 Amplification in the Spectrum of HMGA2-Altered Pleomorphic Adenoma, Atypical Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma
Recurrent MDM2 Amplification in the Spectrum of HMGA2-Altered Pleomorphic Adenoma, Atypical Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma Open
Introduction Pleomorphic adenoma is the most common neoplasm of the salivary glands. While the overall risk of malignancy is relatively low, a distinct molecular sub-group harboring HMGA2 alterations seems to show an increased risk of mali…
View article: Sinonasal Intestinal‐Type Adenocarcinoma in the Netherlands: A Nationwide Study (2008–2022)
Sinonasal Intestinal‐Type Adenocarcinoma in the Netherlands: A Nationwide Study (2008–2022) Open
Background Intestinal‐type adenocarcinoma (ITAC) is a rare sinonasal malignancy with poor survival. By creating a clinical and epidemiological overview of the Dutch ITAC population between 2008 and 2022, this study aims to identify areas f…
View article: Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumours
Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumours Open
This research was supported by the Hanarth Fund.
View article: On the Importance of Text Preprocessing for Multimodal Representation Learning and Pathology Report Generation
On the Importance of Text Preprocessing for Multimodal Representation Learning and Pathology Report Generation Open
Vision-language models in pathology enable multimodal case retrieval and automated report generation. Many of the models developed so far, however, have been trained on pathology reports that include information which cannot be inferred fr…
View article: Pathology Report Generation and Multimodal Representation Learning for Cutaneous Melanocytic Lesions
Pathology Report Generation and Multimodal Representation Learning for Cutaneous Melanocytic Lesions Open
Millions of melanocytic skin lesions are examined by pathologists each year, the majority of which concern common nevi (i.e., ordinary moles). While most of these lesions can be diagnosed in seconds, writing the corresponding pathology rep…
View article: A novel dataset for nuclei and tissue segmentation in melanoma with baseline nuclei segmentation and tissue segmentation benchmarks
A novel dataset for nuclei and tissue segmentation in melanoma with baseline nuclei segmentation and tissue segmentation benchmarks Open
Background Melanoma is an aggressive form of skin cancer in which tumor-infiltrating lymphocytes (TILs) are a biomarker for recurrence and treatment response. Manual TIL assessment is prone to interobserver variability, and current deep le…
View article: Sentinel Lymph Node Detection in Early-Stage Oral Squamous Cell Carcinoma Using Magnetic Resonance Lymphography: A Pilot Study
Sentinel Lymph Node Detection in Early-Stage Oral Squamous Cell Carcinoma Using Magnetic Resonance Lymphography: A Pilot Study Open
Objectives: To assess the efficacy of magnetic resonance (MR) lymphography with gadobutrol contrast for sentinel lymph node (SLN) mapping in early-stage oral squamous cell carcinoma (OSCC). Methods: This pilot study compared the identifica…
View article: Evaluation of the 10 %-rule in sentinel lymph node biopsy for clinically node-negative oral squamous cell carcinoma
Evaluation of the 10 %-rule in sentinel lymph node biopsy for clinically node-negative oral squamous cell carcinoma Open
The 10%-rule in SLNB applies to patients with OSCC and effectively identifies metastatic SLNs intraoperatively. Applying the 10%-rule per neck side must be considered. Increasing the threshold percentage is not advisable.
View article: NAB2::STAT6 Rearranged Carcinoma of the Parotid Gland with Sebaceous Differentiation: A Case Report
NAB2::STAT6 Rearranged Carcinoma of the Parotid Gland with Sebaceous Differentiation: A Case Report Open
The NAB2::STAT6 fusion is predominantly associated with solitary fibrous tumors (SFTs) and is utilized in diagnosing SFTs through nuclear STAT6 protein overexpression. Recent studies expanded the phenotypic spectrum of NAB2::STAT6 rearrang…
View article: Sinonasal Squamous Cell Carcinoma in the Netherlands: A Population‐Based Study of 568 Cases Diagnosed in 2008–2021
Sinonasal Squamous Cell Carcinoma in the Netherlands: A Population‐Based Study of 568 Cases Diagnosed in 2008–2021 Open
Background Sinonasal squamous cell carcinoma is known for its rarity and poor prognosis. This study aims to investigate the trends in the incidence of sinonasal squamous cell carcinoma in the Netherlands and to analyze patient characterist…
View article: Artificial Intelligence-Based Triaging of Cutaneous Melanocytic Lesions
Artificial Intelligence-Based Triaging of Cutaneous Melanocytic Lesions Open
Pathologists are facing an increasing workload due to a growing volume of cases and the need for more comprehensive diagnoses. Aiming to facilitate workload reduction and faster turnaround times, we developed an artificial intelligence (AI…
View article: A Novel Dataset for Nuclei and Tissue Segmentation in Melanoma with baseline nuclei segmentation and tissue segmentation benchmarks
A Novel Dataset for Nuclei and Tissue Segmentation in Melanoma with baseline nuclei segmentation and tissue segmentation benchmarks Open
Background Melanoma is an aggressive form of skin cancer in which tumor-infiltrating lymphocytes (TILs) are a biomarker for recurrence and treatment response. Manual TIL assessment is prone to interobserver variability, and current deep le…
View article: DNA Methylation Profiling of Salivary Gland Tumors Supports and Expands Conventional Classification
DNA Methylation Profiling of Salivary Gland Tumors Supports and Expands Conventional Classification Open
Tumors of the major and minor salivary glands histologically encompass a diverse and partly overlapping spectrum of frequent diagnostically challenging neoplasms. Despite recent advances in molecular testing and the identification of tumor…
View article: MYB immunohistochemistry as a predictor of MYB::NFIB fusion in the diagnosis of adenoid cystic carcinoma of the head and neck
MYB immunohistochemistry as a predictor of MYB::NFIB fusion in the diagnosis of adenoid cystic carcinoma of the head and neck Open
Although MYB protein expression alone lacks diagnostic precision, protein expression >60% predicted the MYB::NFIB fusion in all tumors.