Gerbrich E. van den Bosch

Long-term impact of necrotizing enterocolitis on somatosensory function in preterm born children Open

Judith A. ten Barge, M. Vermeulen, Claudia M. G. Keyzer‐Dekker, Nienke Bouw, Cecile C. de Vos , et al. · 2025

Background Necrotizing enterocolitis (NEC) is a painful intestinal disease in preterm infants that causes severe prolonged pain requiring high amounts of analgesics. In a critical stage of neurodevelopment, pain and analgesics potentially …

Analgosedative prescribing and loading dose strategies in the neonatal intensive care unit: a retrospective cohort study with a focus on hypothermia-treated and extremely premature neonates Open

Samir El Abdouni, Gerbrich E. van den Bosch, J. W. Uiterwijk, Jolette Straatman, Stef Schouwenburg , et al. · 2025

Aim Treating discomfort in neonates is complex, and protocols often lack tailored advice, risking inadequate pain management. This study aims to examine analgosedative prescribing behavior in the Neonatal Intensive Care Unit (NICU) with a …

Pain management in preterm infants with necrotizing enterocolitis: an international expert consensus statement Open

Judith A. ten Barge, Gerbrich E. van den Bosch, Karel Allegaert, Aomesh Bhatt, Nicola Brindley , et al. · 2025

Correction: Complete hepatic caudate lobe resection: is robotic approach safe? Report from experienced centers Open

Greta Donisi, Emanuele Doria, Gregory Sergeant, Gerbrich E. van den Bosch, Fernando Burdı́o , et al. · 2025

Exposure to clinical stressors during NICU admission in preterm infants Open

Naomi Meesters, Gerbrich E. van den Bosch, Maria Luisa Tataranno, Chris H.P. van den Akker, Christ‐jan van Ganzewinkel , et al. · 2025

Examining the association between child development and parental mental health after preterm birth-related stress: a systematic review of the literature and meta-analysis protocol Open

Kirsten S. Muller, Gerbrich E. van den Bosch, Celina E. Henke, Joost G. Daams, Lotte Haverman , et al. · 2025

Introduction Preterm infants born before 32 weeks of gestation are generally admitted to a neonatal intensive care unit (NICU) to receive life-saving treatment, resulting in early exposure to stressful events. Yet, NICU admission is not on…

Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment Open

Judith A. ten Barge, Gerbrich E. van den Bosch, Rebeccah Slater, Nynke J. van den Hoogen, Irwin Reiss , et al. · 2025

Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review. Open

Fiona Moultrie, Xavier Durrmeyer, Gerbrich E. van den Bosch, Manon Tauzin, Jean Roué , et al. · 2024

The purpose of this scoping review is to assess the risks and benefits of providing analgesic and sedative drugs to ventilated premature infants. We sourced primary empirical research reporting outcomes related to the use of pharmacologica…

Parents in Neonatal Pain Management—An International Survey of Parent-Delivered Interventions and Parental Pain Assessment Open

Alexandra Ullsten, Serdar Beken, Marsha Campbell‐Yeo, Giacomo Cavallaro, Nunzia Decembrino , et al. · 2024

Background: While parent-delivered pain management has been demonstrated to effectively reduce neonatal procedural pain responses, little is known about to what extent it is utilized. Our aim was to explore the utilization of parents in ne…

SHOULD WE REPAIR DIASTASIS WHEN IS ASSOCIATED TO PRIMARY VENTRAL HERNIA? Open

Gerbrich E. van den Bosch, A Arango Bravo, María José Pérez, Montserrat Juvany, Laura Riba , et al. · 2024

There is low consensus about rectal diastasis concomitant with a primary ventral hernia. However, the new EHS guidelines recommend joint repair in one time. In our group, in cases of asymptomatic diastasis D1–D2 associated with ventral her…

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit Open

Judith A. ten Barge, Mathilde Baudat, Naomi Meesters, Alida Kindt, Elbert A.J. Joosten , et al. · 2024

Newborns admitted to the neonatal intensive care unit (NICU) regularly undergo painful procedures and may face various painful conditions such as postoperative pain. Optimal management of pain in these vulnerable preterm and term born neon…

A comparison of ultrafast and conventional spectral Doppler ultrasound to measure cerebral blood flow velocity during inguinal hernia repair in infants Open

Mathies Rondagh, Anna J. Kortenbout, Sophie de Munck, Gerbrich E. van den Bosch, Jeroen Dudink , et al. · 2023

The influence of intensive care treatment in infancy on cortisol levels in childhood and adolescence Open

Judith A. ten Barge, Madhvi Moelchand, Monique van Dijk, Sinno H. P. Simons, Joost van Rosmalen , et al. · 2023

Children and adolescents with a history of intensive care treatment in infancy have similar cortisol profiles to those of healthy controls, except for an 18 % lower diurnal cortisol output. The clinical relevance of this reduction is yet t…

Current pain management practices for preterm infants with necrotizing enterocolitis: a European survey Open

Judith A. ten Barge, Gerbrich E. van den Bosch, Naomi Meesters, Karel Allegaert, Cristina Arribas , et al. · 2023

Sedation Prior to Intubation at Birth in Infants with Congenital Diaphragmatic Hernia: An International Survey on Current Practices Open

Emily J.J. Horn-Oudshoorn, Alisa M. Blekherov, Gerbrich E. van den Bosch, Sinno H. P. Simons, Ronny Knol , et al. · 2023

Introduction: Infants with congenital diaphragmatic hernia (CDH) are commonly intubated immediately after birth. Consensus on whether to provide sedation prior to intubation in the delivery room is lacking, although avoidance of stress is …

The Risk for Neonatal Hypoglycemia and Bradycardia after Beta-Blocker Use during Pregnancy or Lactation: A Systematic Review and Meta-Analysis Open

Rosalie de Bruin, Sarah L van Dalen, Shamaya J. Franx, Viraraghavan Vadakkencherry Ramaswamy, Sinno H. P. Simons , et al. · 2022

Beta-blockers are often used during pregnancy to treat cardiovascular diseases. The described neonatal side effects of maternal beta-blocker use are hypoglycemia and bradycardia, but the evidence base for these is yet to be evaluated compr…

Risk for neonatal hypoglycaemia and bradycardia after beta-blocker use during pregnancy or lactation: a systematic review and meta-analysis protocol Open

Rosalie de Bruin, Sarah L van Dalen, Shamaya J. Franx, Sinno H. P. Simons, Robert B. Flint , et al. · 2022

Introduction Beta-blockers are often used during pregnancy to treat diseases such as pre-existing hypertension, arrhythmias or pregnancy-related hypertension. Since beta-blockers are able to cross the placenta and can pass into breast milk…

Neonatal Pain, Opioid, and Anesthetic Exposure; What Remains in the Human Brain After the Wheels of Time? Open

Gerbrich E. van den Bosch, Dick Tibboel, Jurgen C. de Graaff, Hanan El Marroun, Aad van der Lugt , et al. · 2022

Objective To evaluate possible negative long-term effects of neonatal exposure to pain, opioids and anesthetics in children and adolescents. Study Design We studied five unique groups of children recruited from well-documented neonatal coh…

Pain management for necrotizing enterocolitis: getting the balance right Open

Judith A. ten Barge, M. Vermeulen, Sinno H. P. Simons, Gerbrich E. van den Bosch · 2022

Background Adequate pain management for preterm born neonates suffering from the extremely painful disease necrotizing enterocolitis (NEC) is essential, since neonatal exposure to pain is related to negative short-term and long-term conseq…

COVID-19 lockdown impacts the wellbeing of parents with infants on a Dutch neonatal intensive care unit Open

Naomi Meesters, Monique van Dijk, Fernanda Sampaio de Carvalho, Lotte Haverman, Irwin Reiss , et al. · 2021

Developmental neurobiology as a guide for pharmacological management of pain in neonates Open

Nynke J. van den Hoogen, Anne R. de Kort, Karel Allegaert, Elbert A.J. Joosten, Sinno H. P. Simons , et al. · 2019

Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long‐Term Neurodevelopment Open

Raisa M. Schiller, Karel Allegaert, Maayke Hunfeld, Gerbrich E. van den Bosch, John van den Anker , et al. · 2018

Inadequate pain and/or stress management in preterm‐ and term‐born infants has been associated with increased morbidity and even mortality. However, exposure to analgosedatives during early infancy may also be one of the risk factors for s…

Cerebellar Growth Impairment Characterizes School-Aged Children Born Preterm without Perinatal Brain Lesions Open

Kay Pieterman, Tonya White, Gerbrich E. van den Bosch, Wiro J. Niessen, Irwin Reiss , et al. · 2018

The results of our study show that perinatal influences that are not primarily neurologic are still able to disturb long-term neurodevelopment, particularly of the developing cerebellum. Including the cerebellum in future neuroprotective s…

Aberrant White Matter Microstructure in Children and Adolescents With the Subtype of Prader–Willi Syndrome at High Risk for Psychosis Open

Akvile Lukoshe, Gerbrich E. van den Bosch, Aad van der Lugt, Steven A. Kushner, Anita C. S. Hokken‐Koelega , et al. · 2017

Prader-Willi Syndrome (PWS) is a complex neurogenetic disorder caused by loss of the paternal 15q11.2-q13 locus, due to deletion (DEL), maternal uniparental disomy (mUPD), or imprinting center defects. Individuals with mUPD have up to 60% …

Thermal quantitative sensory testing in healthy Dutch children and adolescents standardized test paradigm and Dutch reference values Open

Gerbrich E. van den Bosch, Monique van Dijk, Dick Tibboel, Abraham J. Valkenburg · 2017

Altered functional resting-state hypothalamic connectivity and abnormal pituitary morphology in children with Prader-Willi syndrome Open

Akvile Lukoshe, Suzanne E. van Dijk, Gerbrich E. van den Bosch, Aad van der Lugt, Tonya White , et al. · 2017

Neonatal critical illness and development: white matter and hippocampus alterations in school‐age neonatal extracorporeal membrane oxygenation survivors Open

Raisa M. Schiller, Gerbrich E. van den Bosch, Ryan L. Muetzel, Marion Smits, Jeroen Dudink , et al. · 2016

Aim To examine the neurobiology of long‐term neuropsychological deficits after neonatal extracorporeal membrane oxygenation ( ECMO ). Method This cross‐sectional study assessed white matter integrity and hippocampal volume of ECMO survivor…

Is the Glass Half Full or Half Empty? Open

Gerbrich E. van den Bosch, Tonya White, Dick Tibboel, Monique van Dijk · 2015

mission Errors' had a correlation coefficient of -0.46 with morphine exposure (p = 0.05), i.e. a higher exposure to morphine was associated with a lower number of errors.The other significant correlation of -0.46 indicates that children wi…

Prematurity, Opioid Exposure and Neonatal Pain: Do They Affect the Developing Brain? Open

Gerbrich E. van den Bosch, Tonya White, Hanan El Marroun, Sinno H. P. Simons, Aad van der Lugt , et al. · 2015

Background: Traditionally, 10 years ago, children born preterm often routinely received morphine, especially during mechanical ventilation. Studies in neonatal rats, whose stage of brain development roughly corresponds to tha…

Supplementary Material for: Prematurity, Opioid Exposure and Neonatal Pain: Do They Affect the Developing Brain? Open

Gerbrich E. van den Bosch, Tonya White, Hanan El Marroun, Simons S.H.P., Aad van der Lugt , et al. · 2015

Background: Traditionally, 10 years ago, children born preterm often routinely received morphine, especially during mechanical ventilation. Studies in neonatal rats, whose stage of brain development roughly corresponds to tha…

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