Gerd Heusch
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View article: Perspectives on Artificial Intelligence in Medical Publishing: A Survey of Medical Journal Editors
Perspectives on Artificial Intelligence in Medical Publishing: A Survey of Medical Journal Editors Open
Artificial intelligence (AI) has been increasingly integrated into medical publishing, hopefully improving efficiency and accuracy, but serious concerns persist regarding ethical implications, authorship attribution, and content reliabilit…
Immunometabolism in heart failure Open
The interaction between inflammation and metabolism (immunometabolism) is a crucial factor in the pathophysiology of heart failure, whether the cardiac failure originates from ischaemic injury or systemic metabolic disorders, and whether i…
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop Open
A long-standing aim in the setting of various pathologies including acute myocardial infarction, chronic kidney disease (CKD), and ischaemic stroke, has been to identify successful approaches to augment cellular and organ protection. Altho…
Deep learning segmentation model for quantification of infarct size in pigs with myocardial ischemia/reperfusion Open
Infarct size (IS) is the most robust end point for evaluating the success of preclinical studies on cardioprotection. The gold standard for IS quantification in ischemia/reperfusion (I/R) experiments is triphenyl tetrazolium chloride (TTC)…
Pericytes in the brain and heart: functional roles and response to ischaemia and reperfusion Open
In the last 20 years, there has been a revolution in our understanding of how blood flow is regulated in many tissues. Whereas it used to be thought that essentially all blood flow control occurred at the arteriole level, it is now recogni…
Scientific integrity in the era of predatory journals: Insights from an editors in chief symposium Open
In recent years, the academic community has faced a growing threat from predatory journals. These are publications that prioritize profit over quality scholarship and compromise the integrity of scientific discourse. Predatory journals oft…
Cardioprotection research has left its comfort zone Open
Journal Article Cardioprotection research has left its comfort zone Get access Gerd Heusch, Gerd Heusch West German Heart and Vascular Center, Institute for Pathophysiology, University of Essen Medical School, Hufelandstrasse 55, D-45147 E…
View article: Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning
Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning Open
While early coronary reperfusion via primary percutaneous coronary intervention (pPCI) is established as the most efficacious therapy for minimizing infarct size (IS) in acute ST-elevation myocardial infarction (STEMI), the restoration of …
Differences in vasomotor function of mesenteric arteries between Ossabaw minipigs with predisposition to metabolic syndrome and Göttingen minipigs Open
Animal models with a predisposition to metabolic syndrome and atherosclerosis are attracting growing interest for translational research, as they may better mimic the variability of patients with cardiovascular disease. In Ossabaw minipigs…
Electrical auricular tragus stimulation induces release of circulating cardioprotective factors in healthy human volunteers Open
Background Vagal activation during remote ischemic conditioning (RIC) with subsequent release of cardioprotective factors from the spleen into the circulation reduces infarct size. These humoral cardioprotective factors can be transferred …
Validation of mitochondrial function measurements in permeabilized myocardial tissue from porcine left ventricular specimens with ischemia/reperfusion Open
Background Mitochondrial function is critical to myocardial ischemia/reperfusion injury and cardioprotection. The measurement of mitochondrial function in isolated mitochondria requires cardiac specimens of about 300 mg and is therefore on…
View article: Non-neuronal acetylcholine is causal for cardioprotection by hypoxic preconditioning in adult rat cardiomyocytes
Non-neuronal acetylcholine is causal for cardioprotection by hypoxic preconditioning in adult rat cardiomyocytes Open
Introduction Brief episodes of non-lethal myocardial ischemia/reperfusion preceding more sustained ischemia and reperfusion reduce lethal ischemia/reperfusion injury. The underlying protective signaling mechanisms of such ischemic precondi…
No robust reduction of infarct size and no-reflow by metoprolol pretreatment in adult Göttingen minipigs Open
Whereas prior experiments in juvenile pigs had reported infarct size reduction by intravenous metoprolol early during myocardial ischaemia, two major clinical trials in patients with reperfused acute myocardial infarction were equivocal. W…
View article: Inhibition of proline-rich-tyrosine kinase 2 restores cardioprotection by remote ischemic preconditioning in type 2 diabetes mellitus
Inhibition of proline-rich-tyrosine kinase 2 restores cardioprotection by remote ischemic preconditioning in type 2 diabetes mellitus Open
Background Endothelial function and cardioprotection through remote ischemic preconditioning (rIPC) are severely impaired in type 2 diabetes mellitus (T2DM). Proline-rich tyrosine kinase 2 (Pyk2), a downstream target of the insulin recepto…
Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario Open
Introduction Diazoxide is a powerful cardioprotective agent that activates mitochondrial ATP-dependent K-channels and stimulates mitochondrial respiration. Diazoxide reduced infarct size in isolated rodent heart preparations and upon pretr…
Primordial non-responsiveness: a neglected obstacle to cardioprotection Open
Schematic diagram listing the established confounders of cardioprotection and characterizing in more detail the features of the novel confounder 'primordial non-responsiveness to cardioprotection', as evidenced by lack of protection (reduc…
Supplement - Differences in vasomotor function of mesenteric arteries between Ossabaw minipigs with predisposition to metabolic syndrome and Göttingen minipigs Open
Supplemental figures of the manuscript "Differences in vasomotor function of mesenteric arteries between Ossabaw minipigs with predisposition to metabolic syndrome and Göttingen minipigs"
Cardioprotection and its Translation: A Need for New Paradigms? Or for New Pragmatism? An Opinionated Retro- and Perspective Open
The dawn of cardioprotection by infarct size reduction originated from the idea to favourably alter the oxygen demand–supply balance of the ischaemic/infarcting myocardium by reducing the contractile determinants of its oxygen consumption.…