Gerd Kempermann
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View article: Dynamic mapping of network-level LTP in the hippocampus via high-resolution bioelectrical sensing
Dynamic mapping of network-level LTP in the hippocampus via high-resolution bioelectrical sensing Open
Understanding the complexity of neural network dynamics demands advanced biosensing technologies capable of capturing large-scale interactions with high spatial and temporal precision. Traditional approaches, such as patch-clamp and field …
View article: MEA‐seqX: High‐Resolution Profiling of Large‐Scale Electrophysiological and Transcriptional Network Dynamics
MEA‐seqX: High‐Resolution Profiling of Large‐Scale Electrophysiological and Transcriptional Network Dynamics Open
Concepts of brain function imply congruence and mutual causal influence between molecular events and neuronal activity. Decoding entangled information from concurrent molecular and electrophysiological network events demands innovative met…
View article: Genetic modulation of protein expression in rat brain
Genetic modulation of protein expression in rat brain Open
View article: Beyond nature, nurture, and chance: Individual agency shapes divergent learning biographies and brain connectome
Beyond nature, nurture, and chance: Individual agency shapes divergent learning biographies and brain connectome Open
Individual choices shape life course trajectories of brain structure and function beyond genes and environment. We hypothesized that individual task engagement in response to a learning program results in individualized learning biographie…
View article: Mapping Large-scale Spatiotemporal Dynamics of Synaptic Plasticity and LTP for Memory Encoding in the Hippocampal Network
Mapping Large-scale Spatiotemporal Dynamics of Synaptic Plasticity and LTP for Memory Encoding in the Hippocampal Network Open
Understanding memory formation requires elucidating the intricate dynamics of neuronal networks in the hippocampus, where information is encoded and processed through specific activity patterns and synaptic plasticity. Here, we introduce “…
View article: MEA-seqX: High-resolution Profiling of Large-scale Electrophysiological and Transcriptional Network Dynamics
MEA-seqX: High-resolution Profiling of Large-scale Electrophysiological and Transcriptional Network Dynamics Open
Concepts of brain function imply congruence and mutual causal influence between molecular events and neuronal activity. Decoding entangled information from concurrent molecular and electrophysiological network events demands innovative met…
View article: Genetic Modulation of Protein Expression in Rat Brain
Genetic Modulation of Protein Expression in Rat Brain Open
Genetic variations in protein expression are implicated in a broad spectrum of common diseases and complex traits. However, the fundamental genetic architecture and variation of protein expression have received comparatively less attention…
View article: Exploring social modulation: Microglia as a key mediator of individual immune response, plasticity and pathology in App-NL-G-F mouse model of Alzheimer’s disease
Exploring social modulation: Microglia as a key mediator of individual immune response, plasticity and pathology in App-NL-G-F mouse model of Alzheimer’s disease Open
This study explores the influence of lifestyle on Alzheimer’s disease (AD) progression using App-NL-G-F mice in a complex enrichment system. Mice exhibited social deficits before plaque pathology or memory impairment, revealing a crucial l…
View article: Early-life experience determines the social stability of adult communities in female mice
Early-life experience determines the social stability of adult communities in female mice Open
Early social interactions critically shape lifelong individual behaviour but their development and stability have been difficult to study in laboratory settings. Our experimental platform allows the automated real-time and longitudinal stu…
View article: The<i>Pgb1</i>locus controls glycogen aggregation in astrocytes of the aged hippocampus without impacting cognitive function
The<i>Pgb1</i>locus controls glycogen aggregation in astrocytes of the aged hippocampus without impacting cognitive function Open
In aged humans and mice, aggregates of hypobranched glycogen molecules called polyglucosan bodies (PGBs) accumulate in hippocampal astrocytes. PGBs are known to drive cognitive decline in neurological diseases but remain largely unstudied …
View article: LEARNING INDUCES THE EMERGENCE OF INDIVIDUALITY
LEARNING INDUCES THE EMERGENCE OF INDIVIDUALITY Open
View article: Early-life experience determines the social stability of adult communities in female mice
Early-life experience determines the social stability of adult communities in female mice Open
Home cage RFID-based tracking data of female mice housed in three independent colonies. Data are in the compressed 'RData' format and constitute data objects generated by the R package 'ColonyTrack' (https://rupertoverall.net/ColonyTrack/)…
View article: Early-life experience determines the social stability of adult communities in female mice
Early-life experience determines the social stability of adult communities in female mice Open
Home cage RFID-based tracking data of female mice housed in three independent colonies. Data are in the compressed 'RData' format and constitute data objects generated by the R package 'ColonyTrack' (https://rupertoverall.net/ColonyTrack/)…
View article: The embodied mind in motion: a neuroscientific and philosophical perspective on prevention and therapy of dementia
The embodied mind in motion: a neuroscientific and philosophical perspective on prevention and therapy of dementia Open
The embodied mind in motion is a concept in which health and well-being, prevention and therapy, as well as lifestyle and habits meet. The mind changes profoundly in the course of dementias, affecting daily living and resulting in reduced …
View article: High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics in experience-dependent plasticity
High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics in experience-dependent plasticity Open
Experiential richness creates tissue-level changes and synaptic plasticity as patterns emerge from rhythmic spatiotemporal activity of large interconnected neuronal assemblies. Despite numerous experimental and computational approaches at …
View article: Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging Open
(Cell Metabolism 34, 408–423.e1–e8; March 1, 2022) We regret that a mistake was made in the conversion of dietary selenium supplementation from ppm to molar concentration (see page 9 and Figure 5 legend). The selenium was delivered at a co…
View article: Presymptomatic Reduction of Individuality in the AppNL-F Knockin Model of Alzheimer’s Disease
Presymptomatic Reduction of Individuality in the AppNL-F Knockin Model of Alzheimer’s Disease Open
View article: Cover Image, Volume 33, Issue 4
Cover Image, Volume 33, Issue 4 Open
The cover image is based on the Editorial Adult neurogenesis in the hippocampus by Gerd Kempermann et al., https://doi.org/10.1002/hipo.23525.
View article: Adult neurogenesis in the hippocampus
Adult neurogenesis in the hippocampus Open
View article: Loss of individualized behavioral trajectories in adult neurogenesis‐deficient cyclin <scp>D2</scp> knockout mice
Loss of individualized behavioral trajectories in adult neurogenesis‐deficient cyclin <span>D2</span> knockout mice Open
There is still limited mechanistic insight into how the interaction of individuals with their environment results in the emergence of individuality in behavior and brain structure. Nevertheless, the idea that personal activity shapes the b…
View article: Individual behavioral trajectories shape whole-brain connectivity in mice
Individual behavioral trajectories shape whole-brain connectivity in mice Open
It is widely assumed that our actions shape our brains and that the resulting connections determine who we are. To test this idea in a reductionist setting, in which genes and environment are controlled, we investigated differences in neur…
View article: Author response: Individual behavioral trajectories shape whole-brain connectivity in mice
Author response: Individual behavioral trajectories shape whole-brain connectivity in mice Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract It is wid…
View article: The individuality paradigm: Automated longitudinal activity tracking of large cohorts of genetically identical mice in an enriched environment
The individuality paradigm: Automated longitudinal activity tracking of large cohorts of genetically identical mice in an enriched environment Open
View article: Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults
Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults Open
Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease. This cross-sectional study investigated the association and interplay between m…
View article: Pre-symptomatic reduction of individuality in the App<sup>NL-F</sup> knock-in model of Alzheimer’s disease
Pre-symptomatic reduction of individuality in the App<sup>NL-F</sup> knock-in model of Alzheimer’s disease Open
While one third of the risk for Alzheimer’s disease (AD) is explained by environment and lifestyle, AD pathology also affects individual lifestyle, possibly long before clinical manifestation of dementia. To study this hidden disease effec…
View article: What Is Adult Hippocampal Neurogenesis Good for?
What Is Adult Hippocampal Neurogenesis Good for? Open
Adult hippocampal neurogenesis is a unique and exceptional process in the mammalian brain that in a lifelong and activity-dependent way generates new excitatory principal neurons. A comprehensive view on their function in greater contexts …
View article: Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose
Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose Open
Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases. The molecular relationships between neural stem cell activity, adult neurogenesi…
View article: Individual behavioral trajectories shape whole-brain connectivity in mice
Individual behavioral trajectories shape whole-brain connectivity in mice Open
It is widely assumed that our actions shape our brains and that the resulting connections determine who we are. To test this idea in a reductionist setting, in which genes and environment are controlled, we investigated differences in neur…
View article: Embodied Prevention
Embodied Prevention Open
Evidence-based recommendations for lifestyles to promote healthy cognitive aging (exercise, education, non-smoking, balanced diet, etc.) root in reductionistic studies of mostly physical measurable factors with large effect sizes. In contr…
View article: Rich Experience Boosts Functional Connectome and High-Dimensional Coding in Hippocampal Network
Rich Experience Boosts Functional Connectome and High-Dimensional Coding in Hippocampal Network Open
Challenging the brain with experiential richness creates tissue-level changes and synaptic plasticity, but the interjacent network level has not been accessible. We here show that environmental enrichment has unexpectedly far-reaching effe…