Gerd Leitinger
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View article: A transmission electron microscopy platform for assessing mitochondrial and nuclear architecture in cardiomyocytes
A transmission electron microscopy platform for assessing mitochondrial and nuclear architecture in cardiomyocytes Open
Mitochondria are central to cardiomyocyte function, and their spatial organization regulates nuclear signaling and gene transcription, holding potential for novel cardioprotective interventions. We developed a transmission electron microsc…
View article: Utilizing native nanodiscs to isolate active TRPC3 channels and expand structural analysis capabilities
Utilizing native nanodiscs to isolate active TRPC3 channels and expand structural analysis capabilities Open
Recent advances in structural biology have provided insights into TRPC3, a TRP family member involved in various (patho)physiological processes. However, the lack of structural information on the channel’s open pore hampers understanding o…
View article: Amyloid beta aggregation promoted by iron leads to neuronal loss in an <i>ex vivo</i> model of Alzheimer’s disease
Amyloid beta aggregation promoted by iron leads to neuronal loss in an <i>ex vivo</i> model of Alzheimer’s disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta (Aβ) plaques and neurofibrillary tangles. Despite well-established iron accumulation in the AD brain, its role in exacerbating Aβ toxicity i…
View article: Immune Modulation with Nanodiscs: Surface Charge Dictates Cellular Interactions and Activation of Macrophages and Dendritic-like Cells
Immune Modulation with Nanodiscs: Surface Charge Dictates Cellular Interactions and Activation of Macrophages and Dendritic-like Cells Open
The immunological barrier is among the most significant barriers in vivo. Macrophages and dendritic cells play a crucial role in immune responses, involving phagocytosis, antigen presentation, and triggering adaptive responses. Nanoscale d…
View article: Homocysteine Leads to Decreased Acylcarnitine Levels in the Heart in a Rabbit Model of Atherosclerosis
Homocysteine Leads to Decreased Acylcarnitine Levels in the Heart in a Rabbit Model of Atherosclerosis Open
Cardiovascular disease, the leading cause of death worldwide, is mainly a result of atherosclerosis. However, 50% of all cases of atherosclerosis still cannot be explained by known risk factors including hypercholesterolemia. Hyperhomocyst…
View article: Annexin A5 controls VDAC1-dependent mitochondrial Ca2+ homeostasis and determines cellular susceptibility to apoptosis
Annexin A5 controls VDAC1-dependent mitochondrial Ca2+ homeostasis and determines cellular susceptibility to apoptosis Open
Annexin A5 (AnxA5) is a Ca 2+ -dependent phospholipid-binding protein associated with the regulation of intracellular Ca 2+ homeostasis. However, the precise role of AnxA5 in controlling mitochondrial Ca 2+ signaling remains elusive. Here,…
View article: Cerebral Amyloid Angiopathy like pathology accompanied by intense gliosis in T2D‐induced APPxhQC mice
Cerebral Amyloid Angiopathy like pathology accompanied by intense gliosis in T2D‐induced APPxhQC mice Open
Background Cerebral Amyloid Angiopathy (CAA), characterized by the presence of amyloid β (Aβ) deposits in cerebral blood vessels has been associated with cognitive impairment and Alzheimer’s disease (AD). Vascular risk factors, such as typ…
View article: Simulated Gastrointestinal Fluids Impact the Stability of Polymer-Functionalized Selenium Nanoparticles: Physicochemical Aspects
Simulated Gastrointestinal Fluids Impact the Stability of Polymer-Functionalized Selenium Nanoparticles: Physicochemical Aspects Open
This study highlights the importance of exploring the characteristics of polymer-functionalized SeNPs under gastrointestinal conditions. Such investigations are important for developing nutritional supplements that can gradually release Se…
View article: Effects of Finishing on Surface Roughness of Four Different Glass-Ionomer Cements and One Alkasite: In Vitro Investigation over Time Using Aging Simulation
Effects of Finishing on Surface Roughness of Four Different Glass-Ionomer Cements and One Alkasite: In Vitro Investigation over Time Using Aging Simulation Open
In 2017, Europe implemented a ban on amalgam restorations for children aged <15 years and for pregnant/breastfeeding women, highlighting the need for alternative filling materials exhibiting less surface roughness and enhanced longevity. T…
View article: Homocysteine contributes to atherogenic transformation of the aorta in rabbits in the absence of hypercholesterolemia
Homocysteine contributes to atherogenic transformation of the aorta in rabbits in the absence of hypercholesterolemia Open
Atherosclerosis, the leading cause of cardiovascular disease, cannot be sufficiently explained by established risk factors, including cholesterol. Elevated plasma homocysteine (Hcy) is an independent risk factor for atherosclerosis and is …
View article: TRPC1: The housekeeper of the hippocampus
TRPC1: The housekeeper of the hippocampus Open
The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given…
View article: Archaeosomes for Oral Drug Delivery: From Continuous Microfluidics Production to Powdered Formulations
Archaeosomes for Oral Drug Delivery: From Continuous Microfluidics Production to Powdered Formulations Open
Archaeosomes were manufactured from natural archaeal lipids by a microfluidics-assisted single-step production method utilizing a mixture of di- and tetraether lipids extracted from Sulfolobus acidocaldarius. The primary aim of this study …
View article: Investigation of Hydrocolloid Plant Polysaccharides as Potential Candidates to Mimic the Functions of MUC5B in Saliva
Investigation of Hydrocolloid Plant Polysaccharides as Potential Candidates to Mimic the Functions of MUC5B in Saliva Open
The successful substitution of complex physiological fluids, such as human saliva, remains a major challenge in drug development. Although there are a large number of saliva substitutes on the market, their efficacy is often inadequate due…
View article: Western diet-induced ultrastructural changes in mouse pancreatic acinar cells
Western diet-induced ultrastructural changes in mouse pancreatic acinar cells Open
Mouse models of diet-induced type 2 diabetes mellitus provide powerful tools for studying the structural and physiological changes that are related to the disease progression. In this study, diabetic-like glucose dysregulation was induced …
View article: Sex and genotype dependent differences in amyloid beta levels and lipid metabolism in type 2 diabetic APPxhQC transgenic mice
Sex and genotype dependent differences in amyloid beta levels and lipid metabolism in type 2 diabetic APPxhQC transgenic mice Open
Background Accumulation of amyloid beta (Aβ) and tau proteins have for decades been thought to be central in the pathogenesis of Alzheimer’s disease (AD). More recently, a plethora of evidence emerged that links metabolic dysfunctions such…
View article: Homocysteine contributes to atherogenic transformation of the aorta in rabbits in the absence of hypercholesterolemia
Homocysteine contributes to atherogenic transformation of the aorta in rabbits in the absence of hypercholesterolemia Open
Atherosclerosis, the leading cause of cardiovascular disease, cannot be sufficiently explained by established risk factors such as cholesterol. Elevated plasma homocysteine (Hcy) is an independent risk factor for atherosclerosis and is clo…
View article: Annexin-A5 is fundamental for VDAC1-dependent mitochondrial Ca2+ homeostasis and determines the susceptibility to apoptosis.
Annexin-A5 is fundamental for VDAC1-dependent mitochondrial Ca2+ homeostasis and determines the susceptibility to apoptosis. Open
Annexin-A5 (AnxA5) is a Ca2+-dependent phospholipid-binding protein associated with the regulation of intracellular Ca2+ homeostasis. However, the precise role of AnxA5 in controlling mitochondrial Ca2+ signaling remained elusive. Here, we…
View article: Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation
Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation Open
Defective degradation and clearance of amyloid-β as well as inflammation per se are crucial players in the pathology of Alzheimer's disease (AD). A defective transport across the blood-brain barrier is causative for amyloid-β (Aβ) accumula…
View article: Investigation of the Influence of Wound-Treatment-Relevant Buffer Systems on the Colloidal and Optical Properties of Gold Nanoparticles
Investigation of the Influence of Wound-Treatment-Relevant Buffer Systems on the Colloidal and Optical Properties of Gold Nanoparticles Open
Biocompatible gold nanoparticles (AuNPs) are used in wound healing due to their radical scavenging activity. They shorten wound healing time by, for example, improving re-epithelialization and promoting the formation of new connective tiss…
View article: Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca <sup>2+</sup> signalling in heart failure
Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca <sup>2+</sup> signalling in heart failure Open
Mitochondrial dysfunction in cardiomyocytes is a hallmark of heart failure development. Although initial studies recognized the importance of different mitochondrial subpopulations, there is a striking lack of direct comparison of intrafib…
View article: Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision (Adv. Mater. Technol. 9/2022)
Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision (Adv. Mater. Technol. 9/2022) Open
Photocapacitors In article number 2101159, Eric Daniel Głowacki, Theresa Rienmüller, Rainer Schindl, and co-workers present thin and flexible organic electrolytic photocapacitors (OEPCs) suitable for neuro-stimulation. Like photovoltaic ce…
View article: Three-dimensional SEM, TEM, and STEM for analysis of large-scale biological systems
Three-dimensional SEM, TEM, and STEM for analysis of large-scale biological systems Open
A major aim in structural cell biology is to analyze intact cells in three dimensions, visualize subcellular structures, and even localize proteins at the best possible resolution in three dimensions. Though recently developed electron mic…