Explanipedia

Imaging of Tissue and Cell Dynamics: introduction to the feature issue Open

Kate Grieve, Kostadinka Bizheva, Gereon Hüttmann, Yoshiaki Yasuno · 2025

Imaging of human airways by endoscope-compatible dynamic microscopic optical coherence tomography Open

Cornelia Holzhausen, Hinnerk Schulz‐Hildebrandt, Martin Ahrens, Noah Heldt, Mario Pieper , et al. · 2025

Introduction Microscopy is a cornerstone for diagnostics in lung disease but was traditionally restricted to biopsies and explanted tissue. Microscopic optical coherence tomography (mOCT) produces images with microscopic resolution without…

Guide to dynamic OCT data analysis Open

Noah Heldt, Tual Monfort, Rion Morishita, Robert Schönherr, Olivier Thouvenin , et al. · 2025

Dynamic optical coherence tomography (DOCT) enhances conventional OCT by providing specific information related to flow dynamics, cell motility, and organelle metabolic activity. These biological phenomena can be detected with varying sens…

Label-free volumetric imaging of porcine kidney tissue over extended areas using dynamic MHz-OCT Open

Sazgar Burhan, Madita Göb, Mario Pieper, Tjalfe Laedtke, Thorge Grahl , et al. · 2025

Dynamic optical coherence tomography (dOCT) enables high-resolution, label-free 3D tissue imaging with functional contrast, offering a potential advancement in kidney transplant viability assessment. Currently, no widely accepted non-invas…

Improving dOCT image quality with short sequences and automated binning Open

Noah Heldt, Cornelia Holzhausen, Martin Ahrens, Mario Pieper, Peter König , et al. · 2025

Dynamic optical coherence tomography (dOCT) uses signal fluctuations to contrast different cells and tissues. In this paper, we demonstrate that shortening the time base over which the signal fluctuations are evaluated reduces noise induce…

Label-free visualization and quantitative analysis of Far UV-C skin safety with dynamic optical coherence tomography with subcellular resolution Open

Felix Hilge, Michael Evers, Lara Buhl, Heather Downs, Maron Dolling , et al. · 2025

The recent COVID-19 pandemic sparked interest in interventional public health measures like ultraviolet germicidal irradiation (UVGI) of occupied spaces with the development of Far UV-C (200–230 nm) emitting sources promising similar antim…

Gα<sub>q/11</sub> signaling counteracts endothelial dysfunction in the brain and protects cognition in aged mice Open

Dimitrios Spyropoulos, Dorothea Ziemens, Géza Adam Curley, Anne-Sophie Gutt, Ákos Menyhárt , et al. · 2025

INTRODUCTORY PARAGRAPH Cognitive impairment is a major medical problem in the aging population. The risk of developing cognitive impairment is higher in several systemic conditions like hypertension, diabetes, and obesity 1–3 . While a vas…

Correlation between the microbial growth on different seafoods and the fluorometric response of sensor foils at different storage conditions Open

Alexander Altmann, Marie Krampe, Lea Barnewitz, Eleana Noti, Dominik Dörfel , et al. · 2025

Optical coherence tomography needle probe for real-time visualization of temperature-induced phase changes within subcutaneous fatty tissue Open

Hinnerk Schulz‐Hildebrandt, Michael Evers, Naja Meyer‐Schell, Daniel Karasik, Malte Casper , et al. · 2025

Significance: Selective cryolipolysis is a widely used aesthetic procedure that cools subcutaneous adipose tissue to temperatures as low as to induce fat cell destruction. However, real-time monitoring techniques are lacking, l…

Measuring choriocapillaris blood flow with laser Doppler optical coherence tomography Open

Leo Puyó, Jonas Franke, Lisa Kutzner, Clara Pfäffle, Hendrik Spahr , et al. · 2025

We report on using a laser Doppler processing of Fourier-domain optical coherence tomography (OCT) data for the assessment of pulsatile blood flow in the choriocapillaris. Signal fluctuations in B-scans recorded at 2 kHz were analyzed by F…

Deep Learning for High Speed Optical Coherence Elastography With a Fiber Scanning Endoscope Open

Maximilian Neidhardt, Sarah Latus, Tim Eixmann, Gereon Hüttmann, Alexander Schlaefer · 2024

Tissue stiffness is related to soft tissue pathologies and can be assessed through palpation or via clinical imaging systems, e.g., ultrasound or magnetic resonance imaging. Typically, the image based approaches are not suitable during int…

Unraveling the functional signals of rods and cones in the human retina: separation and analysis Open

Clara Pfäffle, Leo Puyó, Hendrik Spahr, Dierck Hillmann, Yoko Miura , et al. · 2024

In recent years, optoretinography has become an important functional imaging method for the retina, as light-evoked changes in the photoreceptors have been demonstrated for a large number of different OCT systems. Full-field swept-source o…

Virtual Hall sensor triggered multi-MHz endoscopic OCT imaging for stable real-time visualization Open

Awanish Pratap Singh, Madita Göb, Martin Ahrens, Tim Eixmann, Berenice Schulte , et al. · 2024

Circumferential scanning in endoscopic imaging is crucial across various disciplines, and optical coherence tomography (OCT) is often the preferred choice due to its high-speed, high-resolution, and micron-scale imaging capabilities. Moreo…

Abstract: Reducing Domain Shift in Deep Learning for OCT Segmentation using Image Manipulations Open

Marc S. Seibel, Joshua Niemeijer, Marc Rowedder, Helge Sudkamp, Timo Kepp , et al. · 2024

Correlation between the Microbial Growth on Different Seafoods and the Fluorometric Response of Sensor Foils at Different Storage Conditions Open

Alexander Altmann, Marie Krampe, Lea Barnewitz, Eleana Noti, Dominik Dörfel , et al. · 2024

Abstract: Denoising of Home OCT Images using Noise-to-noise Trained on Artificial Eye Data Open

Marc Rowedder, Timo Kepp, Tobias Neumann, Helge Sudkamp, Gereon Hüttmann , et al. · 2024

Diffuse-illumination holographic optical coherence tomography Open

Leo Puyó, Clara Pfäffle, Hendrik Spahr, Jonas Franke, Daniel Bublitz , et al. · 2023

Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing dif…

Diffuse-illumination holographic optical coherence tomography Open

Leo Puyó, Clara Pfäffle, Hendrik Spahr, Jonas Franke, Daniel Bublitz , et al. · 2023

Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing dif…

Porphyrin-based sensor films for monitoring food spoilage Open

Alexander Altmann, Michel Eden, Gereon Hüttmann, Christian Schell, Ramtin Rahmanzadeh · 2023

To increase food safety and to minimize food waste, it is interesting for the food industry and consumers to be able to determine food spoilage continuously and non-destructively. When food of animal origin is degraded, amines are released…

Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media Open

Anke Leichtle, Zuzana Penxová, Thorge Kempin, David Leffers, Martin Ahrens , et al. · 2023

Hypothesis: Otitis media (OM) can be successfully visualized and diagnosed by dynamic microscopic optical coherence tomography (dmOCT). Background: OM is one of the most common infectious diseases and, according to the WHO, one of the lead…

Abstract: Shape-based Segmentation of Retinal Layers and Fluids in OCT Image Data Open

Timo Kepp, Julia Andresen, Claus von der Burchard, Johann Roider, Gereon Hüttmann , et al. · 2023

Intravital imaging of mucus transport in asthmatic mice using microscopic optical coherence tomography Open

Mario Pieper, Hinnerk Schulz‐Hildebrandt, Inken Schmudde, Katharina M. Quell, Yves Laumonnier , et al. · 2022

Asthma is one of the most common chronic diseases. Mucus overproduction is consistently linked to asthma morbidity and mortality. Despite the knowledge of the importance of mucus, little data exist on how mucus is transported in asthma and…

Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer Open

Clara Pfäffle, Hendrik Spahr, Katharina Gercke, Leo Puyó, Svea Höhl , et al. · 2022

Non-invasive spatially resolved functional imaging in the human retina has recently attracted considerable attention. Particularly functional imaging of bipolar and ganglion cells could aid in studying neuronal activity in humans, includin…

Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study Open

Claus von der Burchard, Helge Sudkamp, Jan Tode, Cristoph Ehlken, Konstantine Purtskhvanidze , et al. · 2022

Objectives Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) is a novel OCT technology that was specifically designed for home monitoring of neovascular age-related macular degeneration (AMD). First clinical fin…

Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride Open

Gwen Musial, Tabea Kohlfaerber, Martin Ahrens, Hinnerk Schulz‐Hildebrandt, Philipp Steven , et al. · 2022

The evaluation of the cornea epithelium using dmOCT is helpful to our understanding of the toxic effects of BAK.

Dynamic optical coherence tomography as a new diagnostic tool for otitis media Open

Anke Leichtle, Hinnerk Schulz‐Hildebrandt, Ralf Brinkmann, Gereon Hüttmann, Karl‐Ludwig Bruchhage · 2022

Introduction The definitive therapy of therapy-refractory chronic otitis media mesotympanalis or epitympanalis (cholesteatoma) consists in the surgical resection of the inflammatory progress. Intraoperative diagnostics are limited to the v…

Dynamische optische Kohärenztomographie als neues Diagnoseverfahren für die Otitis media Open

Anke Leichtle, Hinnerk Schulz‐Hildebrandt, Ralf Brinkmann, Gereon Hüttmann, Karl‐Ludwig Bruchhage · 2022

Einleitung Die definitive Therapie der therapierefraktären chronischen Otitis media mesotympanalis oder epitympanalis (Cholesteatom) besteht in der chirurgischen Sanierung des Entzündungsherdes. Die intraoperative Diagnostik ist dabei auf …

Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways Open

Tabea Kohlfaerber, Mario Pieper, Michael Münter, Cornelia Holzhausen, Martin Ahrens , et al. · 2022

In the imaging of airway tissue, optical coherence tomography (OCT) provides cross-sectional images of tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells.…

Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways Open

Tabea Kohlfaerber, Mario Pieper, Michael Münter, Cornelia Holzhausen, Martin Ahrens , et al. · 2022

Imaging airway tissue, optical coherence tomography (OCT) provides cross-sectional images of tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells. By using …

Abstract: 3D Stent Graft Guidance Based on Tracking Systems Open

Sonja Jäckle, Tim Eixmann, Florian Matysiak, Malte Maria Sieren, Marco Horn , et al. · 2022

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