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View article: Comprehensive Insights into Obesity and Type 2 Diabetes from Protein Network, Canonical Pathway, Phosphorylation and Antimicrobial Peptide Signatures of Human Serum
Comprehensive Insights into Obesity and Type 2 Diabetes from Protein Network, Canonical Pathway, Phosphorylation and Antimicrobial Peptide Signatures of Human Serum Open
Background: Obesity is a major risk factor for type 2 diabetes (T2D); however, the molecular links between these conditions are not fully understood. Methods: We performed an integrative serum proteomics study on samples from 134 individua…
View article: Identification of Protein Networks and Biological Pathways Driving the Progression of Atherosclerosis in Human Carotid Arteries Through Mass Spectrometry-Based Proteomics
Identification of Protein Networks and Biological Pathways Driving the Progression of Atherosclerosis in Human Carotid Arteries Through Mass Spectrometry-Based Proteomics Open
Vulnerable atherosclerotic plaques, especially hemorrhaged lesions, are the major cause of mortalities related to vascular pathologies. The early identification of vulnerable plaques helps to stratify patients at risk of developing acute v…
View article: Analysis of Azathioprine Metabolites in Autoimmune Hepatitis Patient Blood—Method Development and Validation
Analysis of Azathioprine Metabolites in Autoimmune Hepatitis Patient Blood—Method Development and Validation Open
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease treated by steroids and immunomodulator thiopurine drugs such as azathioprine (AZA). AZA is metabolized in the human body into bioactive forms such as 6-thioguanine (6-TG) …
View article: Comparative Analysis of Differential Cellular Transcriptome and Proteome Regulation by HIV-1 and HIV-2 Pseudovirions in the Early Phase of Infection
Comparative Analysis of Differential Cellular Transcriptome and Proteome Regulation by HIV-1 and HIV-2 Pseudovirions in the Early Phase of Infection Open
In spite of the similar structural and genomic organization of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2), striking differences exist between them in terms of replication dynamics and clinical manifestation of infection.…
View article: Synthesis of Galacto-oligosaccharides in Milk by Using Bifidobacterium bifidum β-galactosidases (Saphera 2600L and Nola Fit 5500) Immobilized on Chitosan Beads
Synthesis of Galacto-oligosaccharides in Milk by Using Bifidobacterium bifidum β-galactosidases (Saphera 2600L and Nola Fit 5500) Immobilized on Chitosan Beads Open
The lactose intolerance—as a limiting factor for dairy milk consumption—has a high prevalence worldwide. Dairy milk and milk-derived products are major sources of multiple inorganic compounds and nutrients and thus are considered to be fun…
View article: Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma—Alterations in the Defense Mechanism of the Oral Cavity
Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma—Alterations in the Defense Mechanism of the Oral Cavity Open
Oral squamous cell carcinoma (OSCC) is one of the most frequent types of head and neck cancer. Despite the genetic and environmental risk factors, OSCC is also associated with microbial infections and/or dysbiosis. The secreted saliva serv…
View article: Comparative Analysis of Amino Acid and Biogenic Amine Compositions of Fermented Grape Beverages
Comparative Analysis of Amino Acid and Biogenic Amine Compositions of Fermented Grape Beverages Open
Amino acids and biogenic amines are important components of food and beverages. In grape-derived products such as wine and wine vinegar, they can have different origins and can influence the odor and taste of the products. Their concentrat…
View article: Cross-Linking Mass Spectrometry on P-Glycoprotein
Cross-Linking Mass Spectrometry on P-Glycoprotein Open
The ABC transporter P-glycoprotein (Pgp) has been found to be involved in multidrug resistance in tumor cells. Lipids and cholesterol have a pivotal role in Pgp’s conformations; however, it is often difficult to investigate it with convent…
View article: Identification of SARS-CoV-2 Main Protease (Mpro) Cleavage Sites Using Two-Dimensional Electrophoresis and In Silico Cleavage Site Prediction
Identification of SARS-CoV-2 Main Protease (Mpro) Cleavage Sites Using Two-Dimensional Electrophoresis and In Silico Cleavage Site Prediction Open
The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a crucial role in its life cycle. The Mpro-mediated limited proteolysis of the viral polyproteins is necessary for the replication of the virus,…
View article: Salivary chemical barrier proteins in Oral Squamous Cell Carcinoma – Alterations in the defense mechanism of the oral cavity
Salivary chemical barrier proteins in Oral Squamous Cell Carcinoma – Alterations in the defense mechanism of the oral cavity Open
Oral squamous cell carcinoma (OSCC) is one of the most frequent type of head and neck cancers. Despite the genetic and environmental risk factors, OSCC is also associated with microbial infections and/or dysbiosis. The secreted saliva serv…
View article: Salivary chemical barrier proteins in Oral Squamous Cell Carcinoma – Alterations in the defense mechanism of the oral cavity
Salivary chemical barrier proteins in Oral Squamous Cell Carcinoma – Alterations in the defense mechanism of the oral cavity Open
Oral squamous cell carcinoma (OSCC) is one of the most frequent type of head and neck cancers. Despite the genetic and environmental risk factors, OSCC is also associated with microbial infections and/or dysbiosis. The secreted saliva serv…
View article: Chemical Barrier Proteins in Human Body Fluids
Chemical Barrier Proteins in Human Body Fluids Open
Chemical barriers are composed of those sites of the human body where potential pathogens can contact the host cells. A chemical barrier is made up by different proteins that are part of the antimicrobial and immunomodulatory protein/pepti…
View article: Supplementary material for "Chemical barrier proteins in human body fluids"
Supplementary material for "Chemical barrier proteins in human body fluids" Open
Chemical barriers are composed of those sites of the human body where potential pathogens can contact the host cells. A chemical barrier is made up by different proteins that are part of the antimicrobial and immunomodulatory protein/pepti…
View article: Supplementary material for "Chemical barrier proteins in human body fluids"
Supplementary material for "Chemical barrier proteins in human body fluids" Open
Chemical barriers are composed of those sites of the human body where potential pathogens can contact the host cells. A chemical barrier is made up by different proteins that are part of the antimicrobial and immunomodulatory protein/pepti…
View article: Metabolomic Analysis of Serum and Tear Samples from Patients with Obesity and Type 2 Diabetes Mellitus
Metabolomic Analysis of Serum and Tear Samples from Patients with Obesity and Type 2 Diabetes Mellitus Open
Metabolomics strategies are widely used to examine obesity and type 2 diabetes (T2D). Patients with obesity (n = 31) or T2D (n = 26) and sex- and age-matched controls (n = 28) were recruited, and serum and tear samples were collected. The …
View article: Fast and Sensitive Quantification of AccQ-Tag Derivatized Amino Acids and Biogenic Amines by UHPLC-UV Analysis from Complex Biological Samples
Fast and Sensitive Quantification of AccQ-Tag Derivatized Amino Acids and Biogenic Amines by UHPLC-UV Analysis from Complex Biological Samples Open
Metabolomic analysis of different body fluids bears high importance in medical sciences. Our aim was to develop and validate a fast UHPLC-UV method for the analysis of 33 amino acids and biogenic amines from complex biological samples. Acc…
View article: Supplementary files for "Fast and sensitive quantification of AccQ-Tag derivatized amino acids and biogenic amines by UHPLC-UV from complex biological samples"
Supplementary files for "Fast and sensitive quantification of AccQ-Tag derivatized amino acids and biogenic amines by UHPLC-UV from complex biological samples" Open
Supplementary files for "Fast and sensitive quantification of AccQ-Tag derivatized amino acids and biogenic amines by UHPLC-MS from complex biological samples"
View article: Supplementary files for "Fast and sensitive quantification of AccQ-Tag derivatized amino acids and biogenic amines by UHPLC-UV from complex biological samples"
Supplementary files for "Fast and sensitive quantification of AccQ-Tag derivatized amino acids and biogenic amines by UHPLC-UV from complex biological samples" Open
Supplementary files for "Fast and sensitive quantification of AccQ-Tag derivatized amino acids and biogenic amines by UHPLC-MS from complex biological samples"
View article: Cellular Proteo-Transcriptomic Changes in the Immediate Early-Phase of Lentiviral Transduction
Cellular Proteo-Transcriptomic Changes in the Immediate Early-Phase of Lentiviral Transduction Open
Lentivirus-based vectors derived from human immunodeficiency viruses type 1 and 2 (HIV-1 and 2) are widely used tools in research and may also be utilized in clinical settings. Like their parental virions, they are known to depend on the c…
View article: Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis
Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis Open
Aim: The aim of our study was to explore the pathophysiologic role of oxidation of hemoglobin (Hb) to ferrylHb in human atherosclerosis. Results: We observed a severe oxidation of Hb to ferrylHb in complicated atherosclerotic lesions of ca…
View article: Reduced Level of Tear Antimicrobial and Immunomodulatory Proteins as a Possible Reason for Higher Ocular Infections in Diabetic Patients
Reduced Level of Tear Antimicrobial and Immunomodulatory Proteins as a Possible Reason for Higher Ocular Infections in Diabetic Patients Open
(1) Background: Diabetes mellitus is one of the most common metabolic disorders and a risk factor for bacterial ocular infections. Our aim was to examine the antibacterial activity of tears from patients with diabetes mellitus with and wit…
View article: Supplementary files for "Reduced level of tear antimicrobial and immunomodulatory proteins as a possible reason for higher ocular infections in diabetic patients"
Supplementary files for "Reduced level of tear antimicrobial and immunomodulatory proteins as a possible reason for higher ocular infections in diabetic patients" Open
Diabetes mellitus is one of the most common metabolic disorders and a risk factor for bacterial ocular infections. Our aim was to examine the antibacterial activity of tears from patients with diabetes mellitus and diabetic retinopathy. No…
View article: Supplementary files for "Reduced level of tear antimicrobial and immunomodulatory proteins as a possible reason for higher ocular infections in diabetic patients"
Supplementary files for "Reduced level of tear antimicrobial and immunomodulatory proteins as a possible reason for higher ocular infections in diabetic patients" Open
Diabetes mellitus is one of the most common metabolic disorders and a risk factor for bacterial ocular infections. Our aim was to examine the antibacterial activity of tears from patients with diabetes mellitus and diabetic retinopathy. No…
View article: Detection of Antimicrobial Peptides in Stratum Corneum by Mass Spectrometry
Detection of Antimicrobial Peptides in Stratum Corneum by Mass Spectrometry Open
Antimicrobial and immunomodulatory peptides (AMPs) are considered as the key players in the maintenance of skin barrier functions. Here, we developed a novel approach for the examination of AMPs in the outermost layer of the epidermis, nam…
View article: Structural Characterization of Daunomycin-Peptide Conjugates by Various Tandem Mass Spectrometric Techniques
Structural Characterization of Daunomycin-Peptide Conjugates by Various Tandem Mass Spectrometric Techniques Open
The use of peptide-drug conjugates has generated wide interest as targeted antitumor therapeutics. The anthracycline antibiotic, daunomycin, is a widely used anticancer agent and it is often conjugated to different tumor homing peptides. H…
View article: Compounds with Antiviral, Anti-Inflammatory and Anticancer Activity Identified in Wine from Hungary’s Tokaj Region via High Resolution Mass Spectrometry and Bioinformatics Analyses
Compounds with Antiviral, Anti-Inflammatory and Anticancer Activity Identified in Wine from Hungary’s Tokaj Region via High Resolution Mass Spectrometry and Bioinformatics Analyses Open
(1) Background: Wine contains a variety of molecules with potential beneficial effects on human health. Our aim was to examine the wine components with high-resolution mass spectrometry including high-resolution tandem mass spectrometry in…
View article: Tailoring to Search Engines: Bottom-Up Proteomics with Collision Energies Optimized for Identification Confidence
Tailoring to Search Engines: Bottom-Up Proteomics with Collision Energies Optimized for Identification Confidence Open
Bottom-up proteomics relies on identification of peptides from tandem mass spectra, usually via matching against sequence databases. Confidence in a peptide-spectrum match can be characterized by a score value given by the database search …
View article: Heme-Induced Oxidation of Cysteine Groups of Myofilament Proteins Leads to Contractile Dysfunction of Permeabilized Human Skeletal Muscle Fibres
Heme-Induced Oxidation of Cysteine Groups of Myofilament Proteins Leads to Contractile Dysfunction of Permeabilized Human Skeletal Muscle Fibres Open
Heme released from red blood cells targets a number of cell components including the cytoskeleton. The purpose of the present study was to determine the impact of free heme (20–300 µM) on human skeletal muscle fibres made available during …